Search Results - "Eeles, Rosalind A."

Stereotactic body radiotherapy for oligometastases by Tree, Alison C, Dr, Khoo, Vincent S, MD, Eeles, Rosalind A, Prof, Ahmed, Merina, MD, Dearnaley, David P, Prof, Hawkins, Maria A, MD, Huddart, Robert A, PhD, Nutting, Christopher M, Prof, Ostler, Peter J, FRCR, van As, Nicholas J, FRCR

“…Summary The management of metastatic solid tumours has historically focused on systemic treatment given with palliative intent. However, radical surgical…”
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The contribution of rare variation to prostate cancer heritability by Mancuso, Nicholas, Rohland, Nadin, Rand, Kristin A, Tandon, Arti, Allen, Alexander, Quinque, Dominique, Mallick, Swapan, Li, Heng, Stram, Alex, Sheng, Xin, Kote-Jarai, Zsofia, Easton, Douglas F, Eeles, Rosalind A, Le Marchand, Loic, Lubwama, Alex, Stram, Daniel, Watya, Stephen, Conti, David V, Henderson, Brian, Haiman, Christopher A, Pasaniuc, Bogdan, Reich, David

“…Christopher Haiman, Bogdan Pasaniuc, David Reich and colleagues report a major role for low-frequency variation in the risk for prostate cancer. They show that…”
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Comprehensive functional annotation of 77 prostate cancer risk loci by Hazelett, Dennis J, Rhie, Suhn Kyong, Gaddis, Malaina, Yan, Chunli, Lakeland, Daniel L, Coetzee, Simon G, Henderson, Brian E, Noushmehr, Houtan, Cozen, Wendy, Kote-Jarai, Zsofia, Eeles, Rosalind A, Easton, Douglas F, Haiman, Christopher A, Lu, Wange, Farnham, Peggy J, Coetzee, Gerhard A

“…Genome-wide association studies (GWAS) have revolutionized the field of cancer genetics, but the causal links between increased genetic risk and…”
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Risk-Reducing Salpingo-Oophorectomy for the Prevention of BRCA1- and BRCA2-Associated Breast and Gynecologic Cancer: A Multicenter, Prospective Study by KAUFF, Noah D, DOMCHEK, Susan M, NEUHAUSEN, Susan L, DALY, Mary B, MATLOFF, Ellen, BLUM, Joanne L, SABBATINI, Paul, BARAKAT, Richard R, HUDIS, Clifford, NORTON, Larry, OFFIT, Kenneth, REBBECK, Timothy R, FRIEBEL, Tara M, ROBSON, Mark E, LEE, Johanna, GARBER, Judy E, ISAACS, Claudine, EVANS, D. Gareth, LYNCH, Henry, EELES, Rosalind A

“…Risk-reducing salpingo-oophorectomy (RRSO) has been widely adopted as a key component of breast and gynecologic cancer risk-reduction for women with BRCA1 and…”
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Impact of germline DNA repair gene variants on prognosis and treatment of men with advanced prostate cancer by Hansen, Emma B., Karlsson, Questa, Merson, Susan, Wakerell, Sarah, Rageevakumar, Reshma, Jensen, Jørgen B., Borre, Michael, Kote-Jarai, Zsofia, Eeles, Rosalind A., Sørensen, Karina D.

“…The clinical importance of germline variants in DNA repair genes (DRGs) is becoming increasingly recognized, but their impact on advanced prostate cancer…”
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Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease by Mijuskovic, Martina, Saunders, Edward J., Leongamornlert, Daniel A., Wakerell, Sarah, Whitmore, Ian, Dadaev, Tokhir, Cieza-Borrella, Clara, Govindasami, Koveela, Brook, Mark N., Haiman, Christopher A., Conti, David V., Eeles, Rosalind A., Kote-Jarai, Zsofia

“…Background Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation ranging from largely indolent to lethal. We sought to identify a signature…”
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Oligoprogression in Metastatic, Castrate-Resistant Prostate Cancer-Prevalence and Current Clinical Practice by Patel, Priyanka H, Tunariu, Nina, Levine, Daniel S, de Bono, Johann S, Eeles, Rosalind A, Khoo, Vincent, Murray, Julia, Parker, Christopher C, Pathmanathan, Angela, Reid, Alison, van As, Nicholas, Tree, Alison C

“…Oligoprogression is poorly defined in current literature. Little is known about the natural history and significance of oligoprogression in patients with…”
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A Review of Prostate Cancer Genome-Wide Association Studies (GWAS) by Benafif, Sarah, Kote-Jarai, Zsofia, Eeles, Rosalind A

“…Prostate cancer is the most common cancer in men in Europe and the United States. The genetic heritability of prostate cancer is contributed to by both rarely…”
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Telomere length shows no association with BRCA1 and BRCA2 mutation status by Killick, Emma, Tymrakiewicz, Malgorzata, Cieza-Borrella, Clara, Smith, Paula, Thompson, Deborah J, Pooley, Karen A, Easton, Doug F, Bancroft, Elizabeth, Page, Elizabeth, Leongamornlert, Daniel, Kote-Jarai, Zsofia, Eeles, Rosalind A

“…This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of BRCA1 and BRCA2 mutation…”
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Combined Effect of a Polygenic Risk Score and Rare Genetic Variants on Prostate Cancer Risk by Darst, Burcu F., Sheng, Xin, Eeles, Rosalind A., Kote-Jarai, Zsofia, Conti, David V., Haiman, Christopher A.

“…Although prostate cancer is known to have a strong genetic basis and is influenced by both common and rare variants, the ability to investigate the combined…”
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Adjuvant Hormone Therapy May Improve Survival in Epithelial Ovarian Cancer: Results of the AHT Randomized Trial by Eeles, Rosalind A, Morden, James P, Gore, Martin, Mansi, Janine, Glees, John, Wenczl, Miklos, Williams, Christopher, Kitchener, Henry, Osborne, Richard, Guthrie, David, Harper, Peter, Bliss, Judith M

“…To assess the effects of adjuvant hormone therapy (AHT) on survival and disease outcome in women with epithelial ovarian cancer. Participants were…”
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Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE by MAVADDAT, Nasim, PEOCK, Susan, DAVIDSON, Rosemarie, ECCLES, Diana, COLE, Trevor, COOK, Jackie, BREWER, Carole, TISCHKOWITZ, Marc, DOUGLAS, Fiona, HODGSON, Shirley, WALKER, Lisa, PORTEOUS, Mary E, FROST, Debra, MORRISON, Patrick J, SIDE, Lucy E, KENNEDY, M. John, HOUGHTON, Catherine, DONALDSON, Alan, ROGERS, Mark T, DORKINS, Huw, MIEDZYBRODZKA, Zosia, GREGORY, Helen, EASON, Jacqueline, ELLIS, Steve, BARWELL, Julian, MCCANN, Emma, MURRAY, Alex, ANTONIOU, Antonis C, EASTON, Douglas F, PLATTE, Radka, FINEBERG, Elena, EVANS, D. Gareth, IZATT, Louise, EELES, Rosalind A, ADLARD, Julian

“…Reliable estimates of cancer risk are critical for guiding management of BRCA1 and BRCA2 mutation carriers. The aims of this study were to derive penetrance…”
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Genome-wide association studies in cancer by Easton, Douglas F., Eeles, Rosalind A.

“…Genome-wide association studies (GWAS) provide a powerful approach to identify common, low-penetrance disease loci without prior knowledge of location or…”
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Family History of Prostate Cancer and Survival Outcomes in the UK Genetic Prostate Cancer Study by Brook, Mark N., Ní Raghallaigh, Holly, Govindasami, Koveela, Dadaev, Tokhir, Rageevakumar, Reshma, Keating, Diana, Hussain, Nafisa, Osborne, Andrea, Lophatananon, Artitaya, Muir, Kenneth R., Kote-Jarai, Zsofia, Eeles, Rosalind A.

“…A stronger family history of prostate cancer is inversely associated with the risk of all-cause and cancer-specific mortality. This effect is likely to be…”
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Li-Fraumeni syndrome: cancer risk assessment and clinical management by McBride, Kate A., Ballinger, Mandy L., Killick, Emma, Kirk, Judy, Tattersall, Martin H. N., Eeles, Rosalind A., Thomas, David M., Mitchell, Gillian

“…Key Points Inherited cancer predisposition syndromes are increasingly diagnosed due to greater public awareness of germline genetic testing, and also as an…”
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Reply to Kari Hemminki, Jianguang Ji, and Jan Sundquist’s Letter to the Editor re: Mark N. Brook, Holly Ní Raghallaigh, Koveela Govindasami, et al. Family History of Prostate Cancer and Survival Outcomes in the UK Genetic Prostate Cancer Study. Eur Urol 2023;83:257–66 by Brook, Mark N., Ní Raghallaigh, Holly, Kote-Jarai, Zsofia, Eeles, Rosalind A.

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Analysis of Over 140,000 European Descendants Identifies Genetically Predicted Blood Protein Biomarkers Associated with Prostate Cancer Risk by Wu, Lang, Shu, Xiang, Bao, Jiandong, Guo, Xingyi, Kote-Jarai, Zsofia, Haiman, Christopher A, Eeles, Rosalind A, Zheng, Wei

“…Several blood protein biomarkers have been associated with prostate cancer risk. However, most studies assessed only a small number of biomarkers and/or…”
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Identification of Germline Genetic Variants that Increase Prostate Cancer Risk and Influence Development of Aggressive Disease by Saunders, Edward J, Kote-Jarai, Zsofia, Eeles, Rosalind A

“…Prostate cancer (PrCa) is a heterogeneous disease, which presents in individual patients across a diverse phenotypic spectrum ranging from indolent to fatal…”
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BRCA awareness and testing experience in the UK Jewish population: a qualitative study by Sarig, Katrina, Oxley, Samuel, Kalra, Ashwin, Sobocan, Monika, Fierheller, Caitlin T, Sideris, Michail, Gootzen, Tamar, Ferris, Michelle, Eeles, Rosalind A, Evans, D Gareth, Quaife, Samantha L, Manchanda, Ranjit

“…1 in 40 UK Jewish individuals carry a pathogenic variant in . Traditional testing criteria miss half of carriers, and so population genetic testing is being…”
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Prevention and early detection of prostate cancer by Cuzick, Jack, Prof, Thorat, Mangesh A, MBBS, Andriole, Gerald, Prof, Brawley, Otis W, Prof, Brown, Powel H, Prof, Culig, Zoran, MD, Eeles, Rosalind A, Prof, Ford, Leslie G, MD, Hamdy, Freddie C, Prof, Holmberg, Lars, Prof, Ilic, Dragan, PhD, Key, Timothy J, Prof, Vecchia, Carlo La, Prof, Lilja, Hans, Prof, Marberger, Michael, Prof, Meyskens, Frank L, Prof, Minasian, Lori M, MD, Parker, Chris, MD, Parnes, Howard L, MD, Perner, Sven, Prof, Rittenhouse, Harry, PhD, Schalken, Jack, Prof, Schmid, Hans-Peter, Prof, Schmitz-Dräger, Bernd J, Prof, Schröder, Fritz H, Prof, Stenzl, Arnulf, Prof, Tombal, Bertrand, Prof, Wilt, Timothy J, Prof, Wolk, Alicja, Prof

“…Summary Prostate cancer is a common malignancy in men and the worldwide burden of this disease is rising. Lifestyle modifications such as smoking cessation,…”
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