Search Results - "Edwin Chan, H.Y"

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy by Lu, Jia-Hong, Tan, Jie-Qiong, Durairajan, Siva Sundara Kumar, Liu, Liang-Feng, Zhang, Zhuo-Hua, Ma, Long, Shen, Han-Ming, Chan, H.Y. Edwin, Li, Min

“…Accumulation of α-synuclein (α-syn) in the brain is a pathogenic feature and also a causative factor of Parkinson disease. Isorhynchophylline (IsoRhy) is a…”
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A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets by Zhou, Peng, Chan, Becky K.C., Wan, Yuk Kei, Yuen, Chaya T.L., Choi, Gigi C.G., Li, Xinran, Tong, Cindy S.W., Zhong, Sophia S.W., Sun, Jieran, Bao, Yufan, Mak, Silvia Y.L., Chow, Maggie Z.Y., Khaw, Jien Vei, Leung, Suet Yi, Zheng, Zongli, Cheung, Lydia W.T., Tan, Kaeling, Wong, Koon Ho, Chan, H.Y. Edwin, Wong, Alan S.L.

“…We present a CRISPR-based multi-gene knockout screening system and toolkits for extensible assembly of barcoded high-order combinatorial guide RNA libraries en…”
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Preclinial biopharmaceutics and pharmacokinetic characterization of an HIV-1 Replication inhibitor DB213 by Zuo, Zhong, Wang, Qianwen, Wong, Chun-Ho, Hu, Yue, Kwan, Kin Ming, Chan, Edwin H.Y.

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Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila by Chan, H.Y. Edwin, Warrick, John M., Andriola, Isabella, Merry, Diane, Bonini, Nancy M.

“…Spinal and bulbar muscular atrophy (SBMA) is a heritable neurodegenerative disease caused by the expansion of a polyglutamine [poly(Q)] repeat within the…”
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Erratum to: Lu J-H, Tan J-Q, Durairajan SSK, Liu L-F, Zhang Z-H, Ma L, et al. Isorhynchophylline, a natural alkaloid, promotes the degradation of α-synuclein in neuronal cells via inducing autophagy. Autophagy 2012; 8:98-108 by Lu, Jia-Hong, Tan, Jie-Qiong, Durairajan, Siva Sundara Kumar, Liu, Liang-Feng, Zhang, Zhuo-Hua, Ma, Long, Shen, Han-Ming, Chan, H.Y. Edwin, Li, Min

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A Green Fluorescent Protein-Based Reporter for Protein Nuclear Import Studies in Drosophila Cells by Chan, Wing Man, Shaw, Pang Chui, Chan, H.Y. Edwin

“…Green fluorescent protein-based reporters are commonly used to investigate protein nucleocytoplasmic transport. In this study we developed a novel reporter…”
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Recent developments in targeted transgene expression systems by Wong, Azaria Kam Yan, Chan, Ho Yin Edwin, Chan, Wing Man

“…Targeted transgene expression is a commonly used strategy in Drosophila research. Several studies presented at the 49th Annual Drosophila Research Conference…”
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Statistical Design of Experiment (DoE) based development and optimization of DB213 in situ thermosensitive gel for intranasal delivery by Wang, Qianwen, Wong, Chun-Ho, Chan, H.Y. Edwin, Lee, Wai-Yip, Zuo, Zhong

“…[Display omitted] DB213 is an HIV-1 replication inhibitor targeting the Central Nervous System for the treatment of HIV-associated neurocognitive disorders…”
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RNA Toxicity and Perturbation of rRNA Processing in Spinocerebellar Ataxia Type 2 by Li, Pan P., Moulick, Roumita, Feng, Hongxuan, Sun, Xin, Arbez, Nicolas, Jin, Jing, Marque, Leonard O., Hedglen, Erin, Chan, H.Y. Edwin, Ross, Christopher A., Pulst, Stefan M., Margolis, Russell L., Woodson, Sarah, Rudnicki, Dobrila D.

“…ABSTRACT Background Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease caused by expansion of a CAG repeat in Ataxin‐2 (ATXN2) gene. The…”
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Exclusion of unsuitable CNS drug candidates based on their physicochemical properties and unbound fractions in biomatrices for brain microdialysis investigations by Wang, Qianwen, Ren, Tianjing, Zhao, Jiajia, Wong, Chun-Ho, Chan, H.Y. Edwin, Zuo, Zhong

“…[Display omitted] •First comprehensive evaluations on the suitability of CNS drugs for brain microdialysis system investigations.•CNS drugs with both limited…”
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Demonstration of Direct Nose-to-Brain Transport of Unbound HIV-1 Replication Inhibitor DB213 Via Intranasal Administration by Pharmacokinetic Modeling by Wang, Qianwen, Zhang, Yufeng, Wong, Chun-Ho, Edwin Chan, H.Y., Zuo, Zhong

“…Intranasal administration could be an attractive alternative route of administration for the delivery of drugs to the central nervous system (CNS). However,…”
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Maternal oxytocin responsiveness improves specificity of positive social memory recall by Tse, Wai S., Siu, Angela F.Y., Zhang, Qian, Chan, H.Y. Edwin

“…•Maternal oxytocin responsiveness is associated with detail recall of positive social events with their children.•Maternal oxytocin responsiveness is…”
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Efficient brain uptake and distribution of an expanded CAG RNA inhibitor DB213 via intranasal administration by Wang, Qianwen, Peng, Shaohong, Hu, Yue, Wong, Chun-Ho, Kwan, Kin Ming, Chan, H.Y. Edwin, Zuo, Zhong

“…DB213 is an expanded CAG RNA inhibitor targeting polyglutamine diseases. This current study aims to investigate biopharmaceutic characteristics of DB213 as…”
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Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease by Auluck, Pavan K., H. Y. Edwin Chan, Trojanowski, John Q., Virginia M.-Y. Lee, Bonini, Nancy M.

“…Parkinson's disease is a movement disorder characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta. Dopaminergic neuronal…”
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Pharmacokinetics and brain uptake of HIV-1 replication inhibitor DB213 in Sprague-Dawley rats by Wang, Qianwen, Zhang, Yufeng, Qian, Shuai, Peng, Shaohong, Zhang, Qian, Wong, Chun-Ho, Chan, H.Y. Edwin, Zuo, Zhong

“…[Display omitted] •First in vivo pharmacokinetics investigation of a novel HIV-1 replication inhibitor DB213.•LC/MS/MS method for quantification of DB213 was…”
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Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70 by Bonini, Nancy M, Warrick, John M, Chan, H.Y. Edwin, Gray-Board, Gladys L, Chai, Yaohui, Paulson, Henry L

“…At least eight inherited human neurodegenerative diseases are caused by expansion of a polyglutamine domain within the respective proteins. This confers…”
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role of ubiquitin linkages on α-synuclein induced-toxicity in a Drosophila model of Parkinson's disease by Lee, Francesca K.M, Wong, Azaria K.Y, Lee, Yuk Wa, Wan, Oi Wan, Edwin Chan, H.Y, Chung, Kenny K.K

“…Parkinson's disease (PD) is a common movement disorder marked by the loss of dopaminergic (DA) neurons in the brain stem and the presence of intraneuronal…”
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Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila by CHAN, H. Y, WARRICK, John M, GRAY-BOARD, Gladys L, PAULSON, Henry L, BONINI, Nancy M

“…At least eight dominant human neurodegenerative diseases are due to the expansion of a polyglutamine within the disease proteins. This confers toxicity on the…”
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A mannose/glucose-specific lectin from Chinese evergreen chinkapin ( Castanopsis chinensis) by Wong, Jack H., Chan, H.Y. Edwin, Ng, T.B.

“…A mannose/glucose-specific lectin has been purified from Chinese evergreen chinkapin ( Castanopsis chinensis) seeds, one of the most popular foods in East…”
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Sodium dodecyl sulfate-insoluble oligomers are involved in polyglutamine degeneration by Wong, S.L. Alan, Chan, Wing Man, Chan, H.Y. Edwin

“…In polyglutamine (polyQ) degeneration, disease protein that carries an expanded polyQ tract is neurotoxic. Expanded polyQ protein exists in different…”
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