Search Results - "Edwards, Stephen M."

Two Percent of Men with Early-Onset Prostate Cancer Harbor Germline Mutations in the BRCA2 Gene by Edwards, Stephen M., Kote-Jarai, Zsofia, Meitz, Julia, Hamoudi, Rifat, Hope, Questa, Osin, Peter, Jackson, Rachel, Southgate, Christine, Singh, Rashmi, Falconer, Alison, Dearnaley, David P., Ardern-Jones, Audrey, Murkin, Annette, Dowe, Anna, Kelly, Jo, Williams, Sue, Oram, Richard, Stevens, Margaret, Teare, Dawn M., Bruce Ponder, A.J., Gayther, Simon A., Easton, Doug F., Eeles, Rosalind A.

“…Studies of families with breast cancer have indicated that male carriers of BRCA2 mutations are at increased risk of prostate cancer, particularly at an early…”
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Unravelling the genetics of prostate cancer by Edwards, Stephen M., Eeles, Rosalind A.

“…This review describes what is currently known about the genetics of prostate cancer. Traditionally, the genetics of a suspected inherited cancer predisposition…”
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The frequency of germ-line mutations in the breast cancer predisposition genes BRCA1 and BRCA2 in familial prostate cancer by GAYTHER, S. A, DE FOY, K. A. F, FORD, D, SHEARER, R. J, KIRBY, R. S, DOWE, A. L, KELLY, J, STRATTON, M. R, HARRINGTON, P, PHAROAH, P, DUNSMUIR, W. D, EDWARDS, S. M, GILLETT, C, ARDERN-JONES, A, DEARNALEY, D. P, EASTON, D. F

“…Predisposition to prostate cancer has a genetic component, and there are reports of familial clustering of breast and prostate cancer. Two highly penetrant…”
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Macrophage Scavenger Receptor 1 999C>T (R293X) Mutation and Risk of Prostate Cancer by HOPE, Questa, BULLOCK, Sarah, FALCONER, Alison, DOWE, Anna, MUIR, Kenneth, HOULSTON, Richard S, ENGERT, James C, ROQUIS, David, SINNETT, Daniel, SIMARD, Jacques, HEIMDAL, Ketil, MØLLER, Pal, EVANS, Christopher, MAEHLE, Lovise, BADZIOCH, Michael, EELES, Rosalind A, EASTON, Douglas F, ENGLISH, Dallas R, SOUTHEY, Melissa C, HOPPER, John L, FOULKES, William D, GILES, Graham G, MEITZ, Julia, HAMEL, Nancy, EDWARDS, Stephen M, SEVERI, Gianluca, DEARNALEY, David, JHAVAR, Sameer, SOUTHGATE, Christine

“…Background: Variants in the gene encoding the macrophage scavenger receptor 1 (MSR1 4 ) protein have been identified in men with prostate cancer, and several…”
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Identification of seven new prostate cancer susceptibility loci through a genome-wide association study by Shahabi, Ahva, John, Esther M, Lose, Felicity, Lange, Ethan M, Farnham, Jim, Chambers, Suzanne, Southey, Melissa C, Lewis, Sarah J, Huddart, Robert A, Donovan, Jenny L, Rebbeck, Timothy R, Corral, Roman, Al Olama, Ali Amin, Thompson, Alan, Woodhouse, Christopher J, Liu, Jo-Fen, Kote-Jarai, Zsofia, Lu, Yong-Jie, FitzGerald, Liesel M, Wilkinson, Rosemary A, Le Marchand, Loic, Karyadi, Danielle M, Guy, Michelle, Cannon-Albright, Lisa, Stefflova, Klara, Cao, Guangwen, Thibodeau, Stephen N, Stanford, Janet L, Schaid, Daniel, Sawyer, Emma J, Koopmeiners, Joseph S, Meyer, Andreas, Zeegers, Maurice, Auvinen, Anssi, Neal, David E, Saunders, Edward J, Kaneva, Radka, Kolonel, Laurence N, Schleutker, Johanna, Cooney, Kathleen A, Vogel, Walther, Dörk, Thilo, Kedda, Mary Anne, Pow-Sang, Julio, Hutter, Pierre, Van As, Nicholas, Serth, Jürgen, Leongamornlert, Daniel A, Edwards, Stephen M, Tammela, Teuvo L, Eeles, Rosalind A, Haiman, Christopher A, Clements, Judith, Severi, Gianluca, Horwich, Alan, Parker, Christopher C, Hopper, John L, Polanowski, Andrea, Zhang, Hong-Wei, Foulkes, William D, Ray, Anna M, Hamdy, Freddie C, Christmas, Tim, Page, Elizabeth C, Park, Jong Y, Maier, Christiane, Cox, Angela, Ardern-Jones, Audrey T, Ogden, Chris, Tymrakiewicz, Malgorzata, Giles, Graham G, English, Dallas R, Patterson, Briony, Spurdle, Amanda, Lophatananon, Artitaya, Khan, Humera, Easton, Douglas F, Ingles, Sue A, Cooper, Colin S, Aitken, Joanne, Slavov, Chavdar, Gardiner, R A (Frank), Dearnaley, David P, Ostrander, Elaine A, Hall, Amanda L, Mitkova, Atanaska, Wahlfors, Tiina, Luedeke, Manuel, Henderson, Brian E, Khoo, Vincent S, Dickinson, Joanne L, Kwon, Erika M, Chappuis, Pierre O, Muir, Kenneth, Sellers, Thomas A, Morrison, Jonathan, McDonnell, Shannon K, O'Brien, Lynne T, Stern, Mariana C, Batra, Jyotsna

“…Rosalind Eeles and colleagues present a genome-wide association study for prostate cancer. They report seven loci newly associated with prostate cancer…”
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Multiple Loci With Different Cancer Specificities Within the 8q24 Gene Desert by Ghoussaini, Maya, Song, Honglin, Koessler, Thibaud, Al Olama, Ali Amin, Kote-Jarai, Zsofia, Driver, Kristy E., Pooley, Karen A., Ramus, Susan J., Kjaer, Susanne Krüger, Hogdall, Estrid, DiCioccio, Richard A., Whittemore, Alice S., Gayther, Simon A., Giles, Graham G., Guy, Michelle, Edwards, Stephen M., Morrison, Jonathan, Donovan, Jenny L., Hamdy, Freddie C., Dearnaley, David P., Ardern-Jones, Audrey T., Hall, Amanda L., O'Brien, Lynne T., Gehr-Swain, Beatrice N., Wilkinson, Rosemary A., Brown, Paul M., Hopper, John L., Neal, David E., Pharoah, Paul D. P., Ponder, Bruce A. J., Eeles, Rosalind A., Easton, Douglas F., Dunning, Alison M.

“…Recent studies based on genome-wide association, linkage, and admixture scan analysis have reported associations of various genetic variants in 8q24 with…”
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Multiple Novel Prostate Cancer Predisposition Loci Confirmed by an International Study: The PRACTICAL Consortium by KOTE-JARAI, Zsofia, EASTON, Douglas F, COX, Angela, MAIER, Christiane, VOGEL, Walter, GUY, Michelle, MUIR, Kenneth, LOPHATANANON, Artitaya, KEDDA, Mary-Anne, SPURDLE, Amanda, STEGINGA, Suzanne, JOHN, Esther M, STANFORD, Janet L, GILES, Graham, HOPPER, John, CHAPPUIS, Pierre O, HUTTER, Pierre, FOULKES, William D, HAMEL, Nancy, SALINAS, Claudia A, KOOPMEINERS, Joseph S, KARYADI, Danielle M, JOHANNESON, Bo, OSTRANDER, Elaine A, WAHLFORS, Tiina, TAMMELA, Teuvo L, STEM, Mariana C, CORRAL, Roman, MCDONNELL, Shannon K, SCHÜRMANN, Peter, MEYER, Andreas, KUEFER, Rainer, LEONGAMORNLERT, Daniel A, TYMRAKIEWICZ, Malgorzata, SCHLEUTKER, Johanna, LIU, Jo-Fen, O'MARA, Tracy, GARDINER, R. A, AITKEN, Joanne, JOSHI, Amit D, SEVERI, Gianluca, ENGLISH, Dallas R, SOUTHEY, Melissa, EDWARDS, Stephen M, AL OLAMA, Ali Amin, INGLES, Sue A, EELES, Rosalind A, SCHAID, Daniel, THIBODEAU, Stephen, DÖRK, Thilo, NEAL, David

“…A recent genome-wide association study found that genetic variants on chromosomes 3, 6, 7, 10, 11, 19 and X were associated with prostate cancer risk. We…”
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Induction and Rejoining of DNA Double-Strand Breaks in Human Cervix Carcinoma Cell Lines of Differing Radiosensitivity by Kelland, Lloyd R., Edwards, Stephen M., Steel, G. Gordon

“…Five recently established cell lines of human carcinoma of the cervix of varying radiosensitivity have been used to determine whether the induction or…”
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A Critical Exploration of the Ministry of a White Priest within a Black-Majority Congregation by Edwards, Stephen M

“…Many Church of England parishes with Black-majority congregations have a White parish priest. Clergy undergo mandatory racism awareness training yet do not…”
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Androgen receptor polymorphisms: Association with prostate cancer risk, relapse and overall survival by Edwards, Stephen M., Badzioch, Mike D., Minter, Ralph, Hamoudi, Rifat, Collins, Nadine, Ardern‐Jones, Audrey, Dowe, Anna, Osborne, Simon, Kelly, Jo, Shearer, Robert, Easton, Doug F., Saunders, Grady F., Dearnaley, David P., Eeles, Rosalind A.

“…Several reports have suggested that one or both of the trinucleotide repeat polymorphisms in the human androgen receptor (hAR) gene, (CAG)n coding for…”
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Intubating laryngeal mask airway and muscle relaxants: never together? by Edwards, S M, Searl, C P

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Immunohistochemical expression of BRCA2 protein and allelic loss at the BRCA2 locus in prostate cancer by Edwards, Stephen M., Dunsmuir, William D., Gillett, Cheryl E., Lakhani, Sunil R., Corbishley, Catherine, Young, Martin, Kirby, Roger S., Dearnaley, David P., Dowe, Anna, Ardern‐Jones, Audrey, Kelly, Jo, CRC/BPG UK Fmilial Prostate Cancer Study Collaborators, Spurr, Nigel, Barnes, Diana M., Eeles, Rosalind A.

“…Many epidemiological studies have reported an association between breast and prostate cancer. BRCA2 functions as a tumour‐suppressor gene in about 35% of large…”
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No evidence of germline PTEN mutations in familial prostate cancer by FORREST, MATTHEW S, EDWARDS, STEPHEN M, HAMOUDI, RIFAT A, DEARNALEY, DAVID P, ARDEN-JONES, AUDREY, DOWE, ANNA, MURKIN, ANNETTE, KELLY, JO, TEARE, M DAWN, EASTON, DOUGLAS F, KNOWLES, MARGARET A, BISHOP, D TIMOTHY, EELES, ROSALIND A, COLLABORATORS, THE CRC/BPG UK FAMILIAL PROSTATE CANCER STUDY, COLLABORATORS, THE EC BIOMED FAMILIAL PROSTATE CANCER STUDY

“…9 Deletion mapping studies have identified 10q23 to be the minimal region of loss. 10-12 One candidate gene which maps adjacent to this region, MXI1, has been…”
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Immunohistochemical expression of BRCA2 protein and allelic loss at theBRCA2 locus in prostate cancer by Edwards, Stephen M., Dunsmuir, William D., Gillett, Cheryl E., Lakhani, Sunil R., Corbishley, Catherine, Young, Martin, Kirby, Roger S., Dearnaley, David P., Dowe, Anna, Ardern-Jones, Audrey, Kelly, Jo, CRC/BPG UK Fmilial Prostate Cancer, Spurr, Nigel, Barnes, Diana M., Eeles, Rosalind A.

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The repair of identified large DNA adducts induced by 4-nitroquinoline-1-oxide in normal or xeroderma pigmentosum group A human fibroblasts, and the role of DNA polymerases alpha or delta by Jones, C J, Edwards, S M, Waters, R

“…4-Nitroquinoline-1-oxide (4NQO) reacts with DNA primarily at the N2 and C8 of guanosine, with a small percent of reaction at the N6 of adenosine. In human…”
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