Search Results - "Edwards, Stacey L"

Beyond GWASs: Illuminating the Dark Road from Association to Function by Edwards, Stacey L., Beesley, Jonathan, French, Juliet D., Dunning, Alison M.

“…Genome-wide association studies (GWASs) have enabled the discovery of common genetic variation contributing to normal and pathological traits and clinical drug…”
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Resistance to therapy caused by intragenic deletion in BRCA2 by Ashworth, Alan, Edwards, Stacey L, Brough, Rachel, Lord, Christopher J, Natrajan, Rachael, Vatcheva, Radost, Levine, Douglas A, Boyd, Jeff, Reis-Filho, Jorge S

“…Cells with loss of BRCA2 function are defective in homologous recombination (HR) and are highly sensitive to inhibitors of poly(ADP-ribose) polymerase (PARP),…”
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Redefining normal breast cell populations using long noncoding RNAs by Bitar, Mainá, Rivera, Isela Sarahi, Almeida, Isabela, Shi, Wei, Ferguson, Kaltin, Beesley, Jonathan, Lakhani, Sunil R, Edwards, Stacey L, French, Juliet D

“…Abstract Single-cell RNAseq has allowed unprecedented insight into gene expression across different cell populations in normal tissue and disease states…”
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Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage by Betts, Joshua A., Moradi Marjaneh, Mahdi, Al-Ejeh, Fares, Lim, Yi Chieh, Shi, Wei, Sivakumaran, Haran, Tropée, Romain, Patch, Ann-Marie, Clark, Michael B., Bartonicek, Nenad, Wiegmans, Adrian P., Hillman, Kristine M., Kaufmann, Susanne, Bain, Amanda L., Gloss, Brian S., Crawford, Joanna, Kazakoff, Stephen, Wani, Shivangi, Wen, Shu W., Day, Bryan, Möller, Andreas, Cloonan, Nicole, Pearson, John, Brown, Melissa A., Mercer, Timothy R., Waddell, Nicola, Khanna, Kum Kum, Dray, Eloise, Dinger, Marcel E., Edwards, Stacey L., French, Juliet D.

“…Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a…”
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CRISPR-Cas13d screens identify KILR, a breast cancer risk-associated lncRNA that regulates DNA replication and repair by Wang, Lu, Bitar, Mainá, Lu, Xue, Jacquelin, Sebastien, Nair, Sneha, Sivakumaran, Haran, Hillman, Kristine M, Kaufmann, Susanne, Ziegman, Rebekah, Casciello, Francesco, Gowda, Harsha, Rosenbluh, Joseph, Edwards, Stacey L, French, Juliet D

“…Long noncoding RNAs (lncRNAs) have surpassed the number of protein-coding genes, yet the majority have no known function. We previously discovered 844 lncRNAs…”
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CRISPR screens identify gene targets at breast cancer risk loci by Tuano, Natasha K, Beesley, Jonathan, Manning, Murray, Shi, Wei, Perlaza-Jimenez, Laura, Malaver-Ortega, Luis F, Paynter, Jacob M, Black, Debra, Civitarese, Andrew, McCue, Karen, Hatzipantelis, Aaron, Hillman, Kristine, Kaufmann, Susanne, Sivakumaran, Haran, Polo, Jose M, Reddel, Roger R, Band, Vimla, French, Juliet D, Edwards, Stacey L, Powell, David R, Chenevix-Trench, Georgia, Rosenbluh, Joseph

“…Genome-wide association studies (GWAS) have identified > 200 loci associated with breast cancer risk. The majority of candidate causal variants are in…”
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A novel molecular solution for ultraviolet light detection in Caenorhabditis elegans by Edwards, Stacey L, Charlie, Nicole K, Milfort, Marie C, Brown, Brandon S, Gravlin, Christen N, Knecht, Jamie E, Miller, Kenneth G

“…For many organisms the ability to transduce light into cellular signals is crucial for survival. Light stimulates DNA repair and metabolism changes in…”
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Chromatin interactome mapping at 139 independent breast cancer risk signals by Beesley, Jonathan, Sivakumaran, Haran, Moradi Marjaneh, Mahdi, Lima, Luize G, Hillman, Kristine M, Kaufmann, Susanne, Tuano, Natasha, Hussein, Nehal, Ham, Sunyoung, Mukhopadhyay, Pamela, Kazakoff, Stephen, Lee, Jason S, Michailidou, Kyriaki, Barnes, Daniel R, Antoniou, Antonis C, Fachal, Laura, Dunning, Alison M, Easton, Douglas F, Waddell, Nicola, Rosenbluh, Joseph, Möller, Andreas, Chenevix-Trench, Georgia, French, Juliet D, Edwards, Stacey L

“…Genome-wide association studies have identified 196 high confidence independent signals associated with breast cancer susceptibility. Variants within these…”
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Non-coding RNAs underlie genetic predisposition to breast cancer by Moradi Marjaneh, Mahdi, Beesley, Jonathan, O'Mara, Tracy A, Mukhopadhyay, Pamela, Koufariotis, Lambros T, Kazakoff, Stephen, Hussein, Nehal, Fachal, Laura, Bartonicek, Nenad, Hillman, Kristine M, Kaufmann, Susanne, Sivakumaran, Haran, Smart, Chanel E, McCart Reed, Amy E, Ferguson, Kaltin, Saunus, Jodi M, Lakhani, Sunil R, Barnes, Daniel R, Antoniou, Antonis C, Dinger, Marcel E, Waddell, Nicola, Easton, Douglas F, Dunning, Alison M, Chenevix-Trench, Georgia, Edwards, Stacey L, French, Juliet D

“…Genetic variants identified through genome-wide association studies (GWAS) are predominantly non-coding and typically attributed to altered regulatory elements…”
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Rapid one-step selection method for generating nucleic acid aptamers: development of a DNA aptamer against α-bungarotoxin by Lauridsen, Lasse H, Shamaileh, Hadi A, Edwards, Stacey L, Taran, Elena, Veedu, Rakesh N

“…Nucleic acids based therapeutic approaches have gained significant interest in recent years towards the development of therapeutics against many diseases…”
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Sentryn and SAD Kinase Link the Guided Transport and Capture of Dense Core Vesicles in Caenorhabditis elegans by Morrison, Logan M, Edwards, Stacey L, Manning, Laura, Stec, Natalia, Richmond, Janet E, Miller, Kenneth G

“…Dense core vesicles (DCVs) can transmit signals by releasing neuropeptides from specialized synaptic regions called active zones. DCVs reach the active zone by…”
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Long-Range Modulation of PAG1 Expression by 8q21 Allergy Risk Variants by Vicente, Cristina T., Edwards, Stacey L., Hillman, Kristine M., Kaufmann, Susanne, Mitchell, Hayley, Bain, Lisa, Glubb, Dylan M., Lee, Jason S., French, Juliet D., Ferreira, Manuel A.R.

“…The gene(s) whose expression is regulated by allergy risk variants is unknown for many loci identified through genome-wide association studies. Addressing this…”
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Efficient reverse transcription using locked nucleic acid nucleotides towards the evolution of nuclease resistant RNA aptamers by Crouzier, Lucile, Dubois, Camille, Edwards, Stacey L, Lauridsen, Lasse H, Wengel, Jesper, Veedu, Rakesh N

“…Modified nucleotides are increasingly being utilized in the de novo selection of aptamers for enhancing their drug-like character and abolishing the need for…”
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UNC-16 (JIP3) Acts Through Synapse-Assembly Proteins to Inhibit the Active Transport of Cell Soma Organelles to Caenorhabditis elegans Motor Neuron Axons by Edwards, Stacey L, Morrison, Logan M, Yorks, Rosalina M, Hoover, Christopher M, Boominathan, Soorajnath, Miller, Kenneth G

“…The conserved protein UNC-16 (JIP3) inhibits the active transport of some cell soma organelles, such as lysosomes, early endosomes, and Golgi, to the synaptic…”
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Synapse-Assembly Proteins Maintain Synaptic Vesicle Cluster Stability and Regulate Synaptic Vesicle Transport in Caenorhabditis elegans by Edwards, Stacey L, Yorks, Rosalina M, Morrison, Logan M, Hoover, Christopher M, Miller, Kenneth G

“…The functional integrity of neurons requires the bidirectional active transport of synaptic vesicles (SVs) in axons. The kinesin motor KIF1A transports SVs…”
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Functional dissection of breast cancer risk-associated TERT promoter variants by Helbig, Sonja, Wockner, Leesa, Bouendeu, Annick, Hille-Betz, Ursula, McCue, Karen, French, Juliet D, Edwards, Stacey L, Pickett, Hilda A, Reddel, Roger R, Chenevix-Trench, Georgia, Dörk, Thilo, Beesley, Jonathan

“…The multi-cancer susceptibility locus at 5p15.33 includes , encoding the telomerase catalytic subunit. Genome-wide association studies (GWAS) have identified…”
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A Common Variant at the 14q32 Endometrial Cancer Risk Locus Activates AKT1 through YY1 Binding by Painter, Jodie N., Kaufmann, Susanne, O’Mara, Tracy A., Hillman, Kristine M., Sivakumaran, Haran, Darabi, Hatef, Cheng, Timothy H.T., Pearson, John, Kazakoff, Stephen, Waddell, Nicola, Hoivik, Erling A., Goode, Ellen L., Scott, Rodney J., Tomlinson, Ian, Dunning, Alison M., Easton, Douglas F., French, Juliet D., Salvesen, Helga B., Pollock, Pamela M., Thompson, Deborah J., Spurdle, Amanda B., Edwards, Stacey L.

“…A recent meta-analysis of multiple genome-wide association and follow-up endometrial cancer case-control datasets identified a novel genetic risk locus for…”
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Androgen receptor expression predicts breast cancer survival: the role of genetic and epigenetic events by Peters, Kate M, Edwards, Stacey L, Nair, Shalima S, French, Juliet D, Bailey, Peter J, Salkield, Kathryn, Stein, Sandra, Wagner, Sarah, Francis, Glenn D, Clark, Susan J, Brown, Melissa A

“…Breast cancer outcome, including response to therapy, risk of metastasis and survival, is difficult to predict using currently available methods, highlighting…”
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Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2 by Edwards, Stacey L, Charlie, Nicole K, Richmond, Janet E, Hegermann, Jan, Eimer, Stefan, Miller, Kenneth G

“…Despite a key role for dense core vesicles (DCVs) in neuronal function, there are major gaps in our understanding of DCV biogenesis. A genetic screen for…”
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Auxin-Inducible Degron System Reveals Temporal-Spatial Roles of HSF-1 and Its Transcriptional Program in Lifespan Assurance by Morphis, Allison C, Edwards, Stacey L, Erdenebat, Purevsuren, Kumar, Lalit, Li, Jian

“…HSF-1 is a key regulator of cellular proteotoxic stress response and is required for animal lifespan. In , HSF-1 mediated heat shock response (HSR) declines…”
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