Search Results - "Edwards, Shanique K. E."

Osteocyte Vegf-a contributes to myeloma-associated angiogenesis and is regulated by Fgf23 by Mulcrone, Patrick L., Edwards, Shanique K. E., Petrusca, Daniela N., Haneline, Laura S., Delgado-Calle, Jesús, Roodman, G. David

“…Multiple Myeloma (MM) induces bone destruction, decreases bone formation, and increases marrow angiogenesis in patients. We reported that osteocytes (Ocys)…”
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Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes by Edwards, Shanique K E, Baron, Jacqueline, Moore, Carissa R, Liu, Yan, Perlman, David H, Hart, Ronald P, Xie, Ping

“…Identification of novel genetic risk factors is imperative for a better understanding of B lymphomagenesis and for the development of novel therapeutic…”
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Signaling mechanisms of bortezomib in TRAF3-deficient mouse B lymphoma and human multiple myeloma cells by Edwards, Shanique K.E, Han, Yeming, Liu, Yingying, Kreider, Benjamin Z, Liu, Yan, Grewal, Sukhdeep, Desai, Anand, Baron, Jacqueline, Moore, Carissa R, Luo, Chang, Xie, Ping

“…Highlights • Bortezomib induced Noxa and p21, and caused Mcl1 cleavage in TRAF3−/− tumor B cells. • Bortezomib exhibited contrasting roles on NF-κB1 and NF-κB2…”
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N-benzyladriamycin-14-valerate (AD 198) exhibits potent anti-tumor activity on TRAF3-deficient mouse B lymphoma and human multiple myeloma by Edwards, Shanique K E, Moore, Carissa R, Liu, Yan, Grewal, Sukhdeep, Covey, Lori R, Xie, Ping

“…TRAF3, a new tumor suppressor identified in human non-Hodgkin lymphoma (NHL) and multiple myeloma (MM), induces PKCδ nuclear translocation in B cells. The…”
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Expression and function of a novel isoform of Sox5 in malignant B cells by Edwards, Shanique K.E, Desai, Anand, Liu, Yan, Moore, Carissa R, Xie, Ping

“…Abstract Using a mouse model with the tumor suppressor TRAF3 deleted from B cells, we identified Sox5 as a gene strikingly up-regulated in B lymphomas. Sox5…”
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Critical roles of Noxa and Mcl-1 in the signaling mechanisms of bortezomib in TRAF3-deficient mouse B lymphoma and human multiple myeloma cells by Luo, Chang, Han, Yeming, Liu, Yingying, Edwards, Shanique K E, Xie, Ping

“…Abstract Bortezomib, a clinical drug for multiple myeloma (MM) and mantle cell lymphoma, exhibits complex signaling mechanisms, which vary depending on the…”
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