Search Results - "Edwards, Sarah C."

Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells by McGinley, Aoife M., Sutton, Caroline E., Edwards, Sarah C., Leane, Charlotte M., DeCourcey, Joseph, Teijeiro, Ana, Hamilton, John A., Boon, Louis, Djouder, Nabil, Mills, Kingston H.G.

“…Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is…”
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Emerging immunotherapies for metastasis by Edwards, Sarah C., Hoevenaar, Wilma H. M., Coffelt, Seth B.

“…Major advances in cancer immunotherapy have dramatically expanded the potential to manipulate immune cells in cancer patients with metastatic disease to…”
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Th17 cells, γδ T cells and their interplay in EAE and multiple sclerosis by McGinley, Aoife M., Edwards, Sarah C., Raverdeau, Mathilde, Mills, Kingston H.G.

“…Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS) that shares many features with the human disease. This review…”
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PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A-producing γδ T cells by Edwards, Sarah C, Hedley, Ann, Hoevenaar, Wilma H M, Wiesheu, Robert, Glauner, Teresa, Kilbey, Anna, Shaw, Robin, Boufea, Katerina, Batada, Nizar, Hatano, Shinya, Yoshikai, Yasunobu, Blyth, Karen, Miller, Crispin, Kirschner, Kristina, Coffelt, Seth B

“…IL-17A-producing γδ T cells in mice consist primarily of Vγ6+ tissue-resident cells and Vγ4+ circulating cells. How these γδ T cell subsets are regulated…”
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A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans by Edwards, Sarah C, Sutton, Caroline E, Ladell, Kristin, Grant, Emma J, McLaren, James E, Roche, Fiona, Dash, Pradyot, Apiwattanakul, Nopporn, Awad, Walid, Miners, Kelly L, Lalor, Stephen J, Ribot, Julie C, Baik, Song, Moran, Barry, McGinley, Aoife, Pivorunas, Valerie, Dowding, Lori, Macoritto, Michael, Paez-Cortez, Jesus, Slavin, Anthony, Anderson, Graham, Silva-Santos, Bruno, Hokamp, Karsten, Price, David A, Thomas, Paul G, McLoughlin, Rachel M, Mills, Kingston H G

“…T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in…”
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IL-27 maintains cytotoxic Ly6C+ γδ T cells that arise from immature precursors by Wiesheu, Robert, Edwards, Sarah C, Hedley, Ann, Hall, Holly, Tosolini, Marie, Fares da Silva, Marcelo Gregorio Filho, Sumaria, Nital, Castenmiller, Suzanne M, Wardak, Leyma, Optaczy, Yasmin, Lynn, Amy, Hill, David G, Hayes, Alan J, Hay, Jodie, Kilbey, Anna, Shaw, Robin, Whyte, Declan, Walsh, Peter J, Michie, Alison M, Graham, Gerard J, Manoharan, Anand, Halsey, Christina, Blyth, Karen, Wolkers, Monika C, Miller, Crispin, Pennington, Daniel J, Jones, Gareth W, Fournie, Jean-Jacques, Bekiaris, Vasileios, Coffelt, Seth B

“…In mice, γδ-T lymphocytes that express the co-stimulatory molecule, CD27, are committed to the IFNγ-producing lineage during thymic development. In the…”
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Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction by Edwards, Sarah C, Higgins, Sarah C, Mills, Kingston H.G

“…Highlights • A concurrent respiratory infection can ameliorate CNS disease in the EAE model. • Bacterial pathogens can exert bystander suppression on…”
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γδ T Cells and NK Cells - Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity by Edwards, Sarah C, McGinley, Aoife M, McGuinness, Niamh C, Mills, Kingston H G

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41 by Edwards, Sarah C., Sutton, Caroline E., Mills, Kingston H.G.

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41: γβ T cells, a novel T cell subset with a pathogenic role in IL-17-mediated CNS autoimmunity by Edwards, Sarah C., Sutton, Caroline E., Mills, Kingston H.G.

“…Vγ4+ T cells have been identified as the main IL-17-producing γδ T cell in the CNS of mice with experimental autoimmune encephalomyelitis (EAE), an animal…”
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NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression by Curio, Sophie, Edwards, Sarah C, Suzuki, Toshiyasu, McGovern, Jenny, Triulzi, Chiara, Yoshida, Nagisa, Jonsson, Gustav, Glauner, Teresa, Rami, Damiano, Wiesheu, Robert, Kilbey, Anna, Violet Purcell, Rachel, Coffelt, Seth B, Guerra, Nadia

“…γδT cells are unconventional T cells particularly abundant in mucosal tissues that play an important role in tissue surveillance, homeostasis, and cancer. γδT…”
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NKG2D signaling regulates IL-17A-producing [gamma][delta]T cells in mice to promote cancer progression by Sophie Curio, C. Edwards, Sarah, Toshiyasu Suzuki, Jenny McGovern, Chiara Triulzi, Nagisa Yoshida, Gustav Jonsson, Teresa Glauner, Damiano Rami, Robert Wiesheu, Anna Kilbey, Purcell, Rachel Violet, B. Coffelt, Seth, Nadia Guerra

“…[gamma][delta]T cells are unconventional T cells particularly abundant in mucosal tissues that play an important role in tissue surveillance, homeostasis, and…”
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