Search Results - "Edwards, Ross"

Silencing of natural transformation by an RNA chaperone and a multitarget small RNA by Attaiech, Laetitia, Boughammoura, Aïda, Brochier-Armanet, Céline, Allatif, Omran, Peillard-Fiorente, Flora, Edwards, Ross A., Omar, Ayat R., MacMillan, Andrew M., Glover, Mark, Charpentier, Xavier

“…A highly conserved DNA uptake system allows many bacteria to actively import and integrate exogenous DNA. This process, called natural transformation,…”
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Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones by Kim, Hyeong Jin, Black, Mazzen, Edwards, Ross A., Peillard-Fiorente, Flora, Panigrahi, Rashmi, Klingler, David, Eidelpes, Reiner, Zeindl, Ricarda, Peng, Shiyun, Su, Jikun, Omar, Ayat R., MacMillan, Andrew M., Kreutz, Christoph, Tollinger, Martin, Charpentier, Xavier, Attaiech, Laetitia, Glover, J. N. Mark

“…The ProQ/FinO family of RNA binding proteins mediate sRNA-directed gene regulation throughout gram-negative bacteria. Here, we investigate the structural basis…”
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Coal Burning Leaves Toxic Heavy Metal Legacy in the Arctic by McConnell, Joseph R., Edwards, Ross

“…Toxic heavy metals emitted by industrial activities in the midlatitudes are transported through the atmosphere and deposited in the polar regions;…”
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Asymmetric Dynamics Drive Catalytic Activation of the Hsp90 Chaperone by Magnan, Breanna, Chen, Xu Hong, Rashid, Suad, Minard, Alissa, Chau, William, Uyesugi, Toshi, Edwards, Ross A., Panigrahi, Rashmi, Glover, J. N. Mark, LaPointe, Paul, Spyracopoulos, Leo

“…The Hsp90 chaperone is an ATPase enzyme composed of two copies of a three-domain subunit. Hsp90 stabilizes and activates a diverse array of regulatory…”
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Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex by Aceytuno, R Daniel, Piett, Cortt G, Havali-Shahriari, Zahra, Edwards, Ross A, Rey, Martial, Ye, Ruiqiong, Javed, Fatima, Fang, Shujuan, Mani, Rajam, Weinfeld, Michael, Hammel, Michal, Tainer, John A, Schriemer, David C, Lees-Miller, Susan P, Glover, J N Mark

“…Non-homologous end joining (NHEJ) repairs DNA double strand breaks in non-cycling eukaryotic cells. NHEJ relies on polynucleotide kinase/phosphatase (PNKP),…”
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20th-Century doubling in dust archived in an Antarctic Peninsula ice core parallels climate change and desertification in South America by McConnell, Joseph R, Aristarain, Alberto J, Banta, J. Ryan, Edwards, P. Ross, Simões, Jefferson C

“…Crustal dust in the atmosphere impacts Earth's radiative forcing directly by modifying the radiation budget and affecting cloud nucleation and optical…”
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The sensor of the bacterial histidine kinase CpxA is a novel dimer of extracytoplasmic Per-ARNT-Sim domains by Cho, Timothy H.S., Murray, Cameron, Malpica, Roxana, Margain-Quevedo, Rodrigo, Thede, Gina L., Lu, Jun, Edwards, Ross A., Glover, J.N.Mark, Raivio, Tracy L.

“…Histidine kinases are key bacterial sensors that recognize diverse environmental stimuli. While mechanisms of phosphorylation and phosphotransfer by…”
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Investigation of Black Carbon Wet Deposition to the United States from National Atmospheric Deposition Network Samples by Piyaporn Sricharoenvech, Ross Edwards, Müge Yaşar, David Gay, James J. Schauer

“…Black carbon (BC) aerosols from burning biomass, fossil fuels, and waste are transported over large distances in the Earth's atmosphere, absorbing sunlight,…”
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Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis by Zhou, Yeyun, Millott, Robyn, Kim, Hyeong Jin, Peng, Shiyun, Edwards, Ross A., Skene-Arnold, Tamara, Hammel, Michal, Lees-Miller, Susan P., Tainer, John A., Holmes, Charles F.B., Glover, J. N. Mark

“…ASPP (apoptosis-stimulating proteins of p53) proteins bind PP-1c (protein phosphatase 1) and regulate p53 impacting cancer cell growth and apoptosis. Here we…”
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20th-Century Industrial Black Carbon Emissions Altered Arctic Climate Forcing by McConnell, Joseph R, Edwards, Ross, Kok, Gregory L, Flanner, Mark G, Zender, Charles S, Saltzman, Eric S, Banta, J. Ryan, Pasteris, Daniel R, Carter, Megan M, Kahl, Jonathan D.W

“…Black carbon (BC) from biomass and fossil fuel combustion alters chemical and physical properties of the atmosphere and snow albedo, yet little is known about…”
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Insights from Antarctica on volcanic forcing during the Common Era by Sigl, Michael, McConnell, Joseph R., Toohey, Matthew, Curran, Mark, Das, Sarah B., Edwards, Ross, Isaksson, Elisabeth, Kawamura, Kenji, Kipfstuhl, Sepp, Krüger, Kirstin, Layman, Lawrence, Maselli, Olivia J., Motizuki, Yuko, Motoyama, Hideaki, Pasteris, Daniel R., Severi, Mirko

“…Historical aerosol forcing from large volcanic eruptions are reconstructed from sulphate deposition measured in ice cores. This study updates these records by…”
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Structural Insight into BLM Recognition by TopBP1 by Sun, Luxin, Huang, Yuhao, Edwards, Ross A., Yang, Sukmin, Blackford, Andrew N., Niedzwiedz, Wojciech, Glover, J.N. Mark

“…Topoisomerase IIβ binding protein 1 (TopBP1) is a critical protein-protein interaction hub in DNA replication checkpoint control. It was proposed that TopBP1…”
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Microbial life at −13 °C in the brine of an ice-sealed Antarctic lake by Murray, Alison E, Kenig, Fabien, Fritsen, Christian H, McKay, Christopher P, Cawley, Kaelin M, Edwards, Ross, Kuhn, Emanuele, McKnight, Diane M, Ostrom, Nathaniel E, Peng, Vivian, Ponce, Adrian, Priscu, John C, Samarkin, Vladimir, Townsend, Ashley T, Wagh, Protima, Young, Seth A, Yung, Pung To, Doran, Peter T

“…The permanent ice cover of Lake Vida (Antarctica) encapsulates an extreme cryogenic brine ecosystem (−13 °C; salinity, 200). This aphotic ecosystem is anoxic…”
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The WAIS Divide deep ice core WD2014 chronology – Part 2: Annual-layer counting (0–31 ka BP) by Sigl, Michael, Fudge, Tyler J., Winstrup, Mai, Cole-Dai, Jihong, Ferris, David, McConnell, Joseph R., Taylor, Ken C., Welten, Kees C., Woodruff, Thomas E., Adolphi, Florian, Bisiaux, Marion, Brook, Edward J., Buizert, Christo, Caffee, Marc W., Dunbar, Nelia W., Edwards, Ross, Geng, Lei, Iverson, Nels, Koffman, Bess, Layman, Lawrence, Maselli, Olivia J., McGwire, Kenneth, Muscheler, Raimund, Nishiizumi, Kunihiko, Pasteris, Daniel R., Rhodes, Rachael H., Sowers, Todd A.

“…We present the WD2014 chronology for the upper part (0–2850 m; 31.2 ka BP) of the West Antarctic Ice Sheet (WAIS) Divide (WD) ice core. The chronology is based…”
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Antibody Engineering for Optimized Immunotherapy in Alzheimer's Disease by Sumner, Isabelle L, Edwards, Ross A, Asuni, Ayodeji A, Teeling, Jessica L

“…There are nearly 50 million people with Alzheimer's disease (AD) worldwide and currently no disease modifying treatment is available. AD is characterized by…”
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Climate changes modulated the history of Arctic iodine during the Last Glacial Cycle by Corella, Juan Pablo, Maffezzoli, Niccolo, Spolaor, Andrea, Vallelonga, Paul, Cuevas, Carlos A., Scoto, Federico, Müller, Juliane, Vinther, Bo, Kjær, Helle A., Cozzi, Giulio, Edwards, Ross, Barbante, Carlo, Saiz-Lopez, Alfonso

“…Iodine has a significant impact on promoting the formation of new ultrafine aerosol particles and accelerating tropospheric ozone loss, thereby affecting…”
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The fallout from Fukushima Daiichi nuclear accident profiles a new dating reference in ice and comparison with the Chernobyl accident by Wang, Feiteng, Ming, Jing, Edwards, Ross, Li, Zhongqin, Wang, Ninglian

“…Absolute-age dating horizons play a pillar role in the reconstruction of an ice core chronology. In the modern era, these have included the global fallout from…”
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RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment by Hodge, Curtis D., Ismail, Ismail H., Edwards, Ross A., Hura, Greg L., Xiao, Andrew T., Tainer, John A., Hendzel, Michael J., Glover, J. N. Mark

“…DNA double strand break (DSB) responses depend on the sequential actions of the E3 ubiquitin ligases RNF8 and RNF168 plus E2 ubiquitin-conjugating enzyme Ubc13…”
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Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting by Hodge, Curtis D, Edwards, Ross A, Markin, Craig J, McDonald, Darin, Pulvino, Mary, Huen, Michael S. Y, Zhao, Jiyong, Spyracopoulos, Leo, Hendzel, Michael J, Glover, J. N. Mark

“…Ubc13 is an E2 ubiquitin conjugating enzyme that functions in nuclear DNA damage signaling and cytoplasmic NF-κB signaling. Here, we present the structures of…”
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A new bipolar ice core record of volcanism from WAIS Divide and NEEM and implications for climate forcing of the last 2000 years by Sigl, Michael, McConnell, Joseph R., Layman, Lawrence, Maselli, Olivia, McGwire, Ken, Pasteris, Daniel, Dahl-Jensen, Dorthe, Steffensen, Jørgen Peder, Vinther, Bo, Edwards, Ross, Mulvaney, Robert, Kipfstuhl, Sepp

“…Volcanism is a natural climate forcing causing short‐term variations in temperatures. Histories of volcanic eruptions are needed to quantify their role in…”
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