Search Results - "Edwards, R I"

A Bayesian neural network method for adverse drug reaction signal generation by BATE, A, LINDQUIST, M, EDWARDS, I. R, OLSSON, S, ORRE, R, LANSNER, A, DE FREITAS, R. M

“…The database of adverse drug reactions (ADRs) held by the Uppsala Monitoring Centre on behalf of the 47 countries of the World Health Organization (WHO)…”
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The application of knowledge discovery in databases to post-marketing drug safety: example of the WHO database by Bate, A., Lindquist, M., Edwards, I.R.

“…After market launch, new information on adverse effects of medicinal products is almost exclusively first highlighted by spontaneous reporting. As data sets of…”
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Adverse drug reactions: definitions, diagnosis, and management by Edwards, I Ralph, Aronson, Jeffrey K

“…We define an adverse drug reaction as “an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product,…”
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Data Mining in Spontaneous Reports by Bate, Andrew, Edwards, I. R.

“…: The increasing size of spontaneous report data sets and the increasing capability for screening such data due to increases in computational power has led to…”
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Harmonisation in pharmacovigilance by EDWARDS, I. R, BIRIELL, C

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Can intranasal corticosteroids cause migraine-like headache? by Pokladnikova, J, Meyboom, R H B, Vlcek, J, Edwards, R I

“…Intranasal corticosteroids (INCs) act predominantly locally and are considered to exert minimal systemic effects. On reviewing the international data collected…”
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Principles of signal detection in pharmacovigilance by MEYBOOM, R. H. B, EGBERTS, A. C. G, EDWARDS, I. R, HEKSTER, Y. A, DE KONING, F. H. P, GRIBNAU, F. W. J

“…Adverse drug effects are manifold and heterogenous. Many situations may hamper the signalling (i.e. the detection of early warning signs) of adverse effects…”
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The WHO Programme for International Drug Monitoring, its database, and the technical support of the Uppsala Monitoring Center by LINDQUIST, Marie, EDWARDS, I. Ralph

“…We describe the development of an international adverse reaction database. The operational responsibility for technical aspects of international drug…”
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Risks of non-sedating antihistamines by Lindquist, M, Edwards, I R

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A retrospective evaluation of a data mining approach to aid finding new adverse drug reaction signals in the who international database by LINDQUIST, Marie, STAHL, Malin, BATE, Andrew, EDWARDS, I. Ralph, MEYBOOM, Ronald H. B

“…The detection of new drug safety signals is of growing importance with ever more new drugs becoming available and exposure to medicines increasing. The task of…”
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Ingestion of a quadhelix appliance requiring surgical removal: a case report by Allwork, J. J, Edwards, I. R, Welch, I. M

“…This report presents an unusual case, whereby a 13-year-old Down’s syndrome boy accidentally swallowed a removable quadhelix appliance that subsequently…”
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Introducing triage logic as a new strategy for the detection of signals in the WHO Drug Monitoring Database by Ståhl, M., Lindquist, M., Edwards, I. R., Brown, E. G.

“…Purpose An important role for the WHO Programme for International Drug Monitoring is to identify signals of international drug safety problems as early as…”
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Causal or casual? The role of causality assessment in pharmacovigilance by MEYBOOM, R. H. B, HEKSTER, Y. A, EGBERTS, A. C. G, GRIBNAU, F. W. J, EDWARDS, I. R

“…As with any other study method, 'spontaneous reporting' in pharmacovigilance is a process of data acquisition, assessment, presentation and interpretation. The…”
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A data mining approach for signal detection and analysis by BATE, Andrew, LINDQUIST, Marie, EDWARDS, I. Ralph, ORRE, Roland

“…The WHO database contains over 2.5 million case reports, analysis of this data set is performed with the intention of signal detection. This paper presents an…”
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Tachycardia during cisapride treatment by Olsson, S., Edwards, I. R.

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Data-mining analyses of pharmacovigilance signals in relation to relevant comparison drugs by BATE, A, LINDQUIST, M, ORRE, R, EDWARDS, I. R, MEYBOOM, R. H. B

“…The aim of this paper is to demonstrate the usefulness of the Bayesian Confidence Propagation Neural Network (BCPNN) in the detection of drug-specific and…”
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Withdrawal reactions with selective serotonin re-uptake inhibitors as reported to the WHO system by STAHL, M. M. S, LINDQUIST, M, PETTERSSON, M, EDWARDS, I. R, SANDERSON, J. H, TAYLOR, N. F. A, FLETCHER, A. P, SCHOU, J. S

“…The present study was performed both to investigate whether there might be a difference between the selective serotonin re-uptake inhibitors, (SSRIs) with…”
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Signal selection and follow-up in pharmacovigilance by MEYBOOM, Ronald H. B, LINDQUIST, Marie, EGBERTS, Antoine C. G, EDWARDS, I. Ralph

“…The detection of unknown and unexpected connections between drug exposure and adverse events is one of the major challenges of pharmacovigilance. For the…”
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Who cares about pharmacovigilance? by EDWARDS, I. R

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The management of adverse drug reactions: from diagnosis to signal by Edwards, I R

“…Severe adverse reactions (ADR) are uncommon and benefits of drug treatment usually outweigh the disadvantages. Definitions and guidelines for managing adverse…”
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