Search Results - "Edwards, Lindsay M."

Metabolic phenotype of skeletal muscle in early critical illness by Puthucheary, Zudin A, Astin, Ronan, Mcphail, Mark J W, Saeed, Saima, Pasha, Yasmin, Bear, Danielle E, Constantin, Despina, Velloso, Cristiana, Manning, Sean, Calvert, Lori, Singer, Mervyn, Batterham, Rachel L, Gomez-Romero, Maria, Holmes, Elaine, Steiner, Michael C, Atherton, Philip J, Greenhaff, Paul, Edwards, Lindsay M, Smith, Kenneth, Harridge, Stephen D, Hart, Nicholas, Montgomery, Hugh E

“…To characterise the sketetal muscle metabolic phenotype during early critical illness. Vastus lateralis muscle biopsies and serum samples (days 1 and 7) were…”
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Host-Microbial Interactions in Idiopathic Pulmonary Fibrosis by Molyneaux, Philip L, Willis-Owen, Saffron A G, Cox, Michael J, James, Phillip, Cowman, Steven, Loebinger, Michael, Blanchard, Andrew, Edwards, Lindsay M, Stock, Carmel, Daccord, Cécile, Renzoni, Elisabetta A, Wells, Athol U, Moffatt, Miriam F, Cookson, William O C, Maher, Toby M

“…Changes in the respiratory microbiome are associated with disease progression in idiopathic pulmonary fibrosis (IPF). The role of the host response to the…”
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Metabolomics data normalization with EigenMS by Karpievitch, Yuliya V, Nikolic, Sonja B, Wilson, Richard, Sharman, James E, Edwards, Lindsay M

“…Liquid chromatography mass spectrometry has become one of the analytical platforms of choice for metabolomics studies. However, LC-MS metabolomics data can…”
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Durability of protection and immunogenicity of AZD1222 (ChAdOx1 nCoV-19) COVID-19 vaccine over 6 months by Sobieszczyk, Magdalena E, Maaske, Jill, Falsey, Ann R, Sproule, Stephanie, Robb, Merlin L, Frenck, Jr, Robert W, Tieu, Hong-Van, Mayer, Kenneth H, Corey, Lawrence, Neuzil, Kathleen M, Tong, Tina, Brewinski Isaacs, Margaret, Janes, Holly, Bansal, Himanshu, Edwards, Lindsay M, Green, Justin A, Kelly, Elizabeth J, Shoemaker, Kathryn, Takas, Therese, White, Tom, Bhuyan, Prakash, Villafana, Tonya, Hirsch, And Ian

“…BackgroundWe report updated safety, efficacy, and immunogenicity of AZD1222 (ChAdOx1 nCoV-19) from an ongoing phase 3 trial.MethodsAdults at increased risk of…”
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Acute Dietary Nitrate Supplementation and Exercise Performance in COPD: A Double-Blind, Placebo-Controlled, Randomised Controlled Pilot Study by Curtis, Katrina J, O'Brien, Katie A, Tanner, Rebecca J, Polkey, Juliet I, Minnion, Magdalena, Feelisch, Martin, Polkey, Michael I, Edwards, Lindsay M, Hopkinson, Nicholas S

“…Dietary nitrate supplementation can enhance exercise performance in healthy people, but it is not clear if it is beneficial in COPD. We investigated the…”
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Regulation of human metabolism by hypoxia-inducible factor by Formenti, Federico, Constantin-Teodosiu, Dumitru, Emmanuel, Yaso, Cheeseman, Jane, Dorrington, Keith L., Edwards, Lindsay M., Humphreys, Sandy M., Lappin, Terence R. J., McMullin, Mary F., McNamara, Christopher J., Mills, Wendy, Murphy, John A., O'Connor, David F., Percy, Melanie J., Ratcliffe, Peter J., Smith, Thomas G., Treacy, Marilyn, Frayn, Keith N., Greenhaff, Paul L., Karpe, Fredrik, Clarke, Kieran, Robbins, Peter A., Kaelin, William G.

“…The hypoxia-inducible factor (HIF) family of transcription factors directs a coordinated cellular response to hypoxia that includes the transcriptional…”
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Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome by Yin, Xiaoke, Dwyer, Joseph, Langley, Sarah R, Mayr, Ursula, Xing, Qiuru, Drozdov, Ignat, Nabeebaccus, Adam, Shah, Ajay M, Madhu, Basetti, Griffiths, John, Edwards, Lindsay M, Mayr, Manuel

“…Abstract Perhexiline is a potent anti-anginal drug used for treatment of refractory angina and other forms of heart disease. It provides an oxygen sparing…”
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Metabolomics reveals increased isoleukotoxin diol (12,13-DHOME) in human plasma after acute Intralipid infusion by Edwards, Lindsay M., Lawler, Nathan G., Nikolic, Sonja B., Peters, James M., Horne, James, Wilson, Richard, Davies, Noel W., Sharman, James E.

“…Intralipid is a fat emulsion that is regularly infused into humans and animals. Despite its routine use, Intralipid infusion can cause serious adverse…”
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The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition by Edwards, Lindsay M, Murray, Andrew J, Tyler, Damian J, Kemp, Graham J, Holloway, Cameron J, Robbins, Peter A, Neubauer, Stefan, Levett, Denny, Montgomery, Hugh E, Grocott, Mike P, Clarke, Kieran

“…Many disease states are associated with regional or systemic hypoxia. The study of healthy individuals exposed to high-altitude hypoxia offers a way to explore…”
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The reproducibility of 31-phosphorus MRS measures of muscle energetics at 3 Tesla in trained men by Edwards, Lindsay M, Tyler, Damian J, Kemp, Graham J, Dwyer, Renee M, Johnson, Andrew, Holloway, Cameron J, Nevill, Alan M, Clarke, Kieran

“…Magnetic resonance spectroscopy (MRS) provides an exceptional opportunity for the study of in vivo metabolism. MRS is widely used to measure phosphorus…”
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Metabolic systems biology: a brief primer by Edwards, Lindsay M.

“…In the early to mid‐20th century, reductionism as a concept in biology was challenged by key thinkers, including Ludwig von Bertalanffy. He proposed that…”
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Acute Skeletal Muscle Wasting in Critical Illness by Puthucheary, Zudin A, Rawal, Jaikitry, McPhail, Mark, Connolly, Bronwen, Ratnayake, Gamunu, Chan, Pearl, Hopkinson, Nicholas S, Padhke, Rahul, Dew, Tracy, Sidhu, Paul S, Velloso, Cristiana, Seymour, John, Agley, Chibeza C, Selby, Anna, Limb, Marie, Edwards, Lindsay M, Smith, Kenneth, Rowlerson, Anthea, Rennie, Michael John, Moxham, John, Harridge, Stephen D. R, Hart, Nicholas, Montgomery, Hugh E

“…IMPORTANCE Survivors of critical illness demonstrate skeletal muscle wasting with associated functional impairment. OBJECTIVE To perform a comprehensive…”
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The metabolomics of alpha-synuclein (SNCA) gene deletion and mutation in mouse brain by Musgrove, Ruth E., Horne, James, Wilson, Richard, King, Anna E., Edwards, Lindsay M., Dickson, Tracey C.

“…Using a novel metabolomics approach the current study aimed to further characterize the functional attributes of alpha-synuclein that mediate its involvement…”
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Metabolomics in hypertension by Nikolic, Sonja B, Sharman, James E, Adams, Murray J, Edwards, Lindsay M

“…Hypertension is the most prevalent chronic medical condition and a major risk factor for cardiovascular morbidity and mortality. In the majority of…”
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Durability of protection and immunogenicity of AZD1222 (ChAdOx1 nCoV-19) COVID-19 vaccine over 6 months by Sobieszczyk, Magdalena E, Maaske, Jill, Falsey, Ann R, Sproule, Stephanie, Robb, Merlin L, Frenck, Robert W, Tieu, Hong-Van, Mayer, Kenneth H, Corey, Lawrence, Neuzil, Kathleen M, Tong, Tina, Isaacs, Margaret Brewinski, Janes, Holly, Bansal, Himanshu, Edwards, Lindsay M, Green, Justin A, Kelly, Elizabeth J, Shoemaker, Kathryn, Takas, Therese, White, Tom, Bhuyan, Prakash, Villafana, Tonya, Hirsch, Ian

“…BACKGROUND. We report updated safety, efficacy, and immunogenicity of AZD1222 (ChAdOx1 nCoV-19) from an ongoing phase 3 trial. METHODS. Adults at increased…”
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Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis by Guillotin, Delphine, Taylor, Adam R, Platé, Manuela, Mercer, Paul F, Edwards, Lindsay M, Haggart, Ross, Miele, Gino, McAnulty, Robin J, Maher, Toby M, Hynds, Robert E, Jamal-Hanjani, Mariam, Marshall, Richard P, Fisher, Andrew J, Blanchard, Andy D, Chambers, Rachel C

“…Fibroblastic foci represent the cardinal pathogenic lesion in idiopathic pulmonary fibrosis (IPF) and comprise activated fibroblasts and myofibroblasts, the…”
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A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects by Holloway, Cameron J, Cochlin, Lowri E, Emmanuel, Yaso, Murray, Andrew, Codreanu, Ion, Edwards, Lindsay M, Szmigielski, Cezary, Tyler, Damian J, Knight, Nicholas S, Saxby, Brian K, Lambert, Bridget, Thompson, Campbell, Neubauer, Stefan, Clarke, Kieran

“…Background: High-fat, low-carbohydrate diets are widely used for weight reduction, but they may also have detrimental effects via increased circulating free…”
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Metabolomic and lipidomic plasma profile changes in human participants ascending to Everest Base Camp by O’Brien, Katie A., Atkinson, R. Andrew, Richardson, Larissa, Koulman, Albert, Murray, Andrew J., Harridge, Stephen D. R., Martin, Daniel S., Levett, Denny Z. H., Mitchell, Kay, Mythen, Monty G., Montgomery, Hugh E., Grocott, Michael P. W., Griffin, Julian L., Edwards, Lindsay M.

“…At high altitude oxygen delivery to the tissues is impaired leading to oxygen insufficiency (hypoxia). Acclimatisation requires adjustment to tissue…”
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Short‐term consumption of a high‐fat diet impairs whole‐body efficiency and cognitive function in sedentary men by Edwards, Lindsay M., Murray, Andrew J., Holloway, Cameron J., Carter, Emma E., Kemp, Graham J., Codreanu, Ion, Brooker, Helen, Tyler, Damian J., Robbins, Peter A., Clarke, Kieran

“…We recently showed that a short‐term high‐fat diet blunted exercise performance in rats, accompanied by increased uncoupling protein levels and greater…”
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Mitochondria and heart failure by Murray, Andrew J, Edwards, Lindsay M, Clarke, Kieran

“…PURPOSE OF REVIEWEnergetic abnormalities in cardiac and skeletal muscle occur in heart failure and correlate with clinical symptoms and mortality. It is likely…”
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