Search Results - "Edwards, John E."

The NDV-3A vaccine protects mice from multidrug resistant Candida auris infection by Singh, Shakti, Uppuluri, Priya, Mamouei, Zeinab, Alqarihi, Abdullah, Elhassan, Hana, French, Samuel, Lockhart, Shawn R, Chiller, Tom, Edwards, Jr, John E, Ibrahim, Ashraf S

“…Candida auris is an emerging, multi-drug resistant, health care-associated fungal pathogen. Its predominant prevalence in hospitals and nursing homes indicates…”
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Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice by Lin, Lin, Ibrahim, Ashraf S, Xu, Xin, Farber, Joshua M, Avanesian, Valentina, Baquir, Beverlie, Fu, Yue, French, Samuel W, Edwards, Jr, John E, Spellberg, Brad

“…We sought to define protective mechanisms of immunity to Staphylococcus aureus and Candida albicans bloodstream infections in mice immunized with the…”
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GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis by Alqarihi, Abdullah, Gebremariam, Teclegiorgis, Gu, Yiyou, Swidergall, Marc, Alkhazraji, Sondus, Soliman, Sameh S M, Bruno, Vincent M, Edwards, Jr, John E, Filler, Scott G, Uppuluri, Priya, Ibrahim, Ashraf S

“…Mucormycosis, caused by species, is a life-threatening fungal infection that occurs in patients immunocompromised by diabetic ketoacidosis (DKA), cytotoxic…”
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Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis by Gebremariam, Teclegiorgis, Lin, Lin, Liu, Mingfu, Kontoyiannis, Dimitrios P, French, Samuel, Edwards, Jr, John E, Filler, Scott G, Ibrahim, Ashraf S

“…Patients with diabetic ketoacidosis (DKA) are uniquely predisposed to mucormycosis, an angioinvasive fungal infection with high mortality. Previously, we…”
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Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America by Boucher, Helen W., Talbot, George H., Bradley, John S., Edwards, John E., Gilbert, David, Rice, Louis B., Scheld, Michael, Spellberg, Brad, Bartlett, John

“…The Infectious Diseases Society of America (IDSA) continues to view with concern the lean pipeline for novel therapeutics to treat drug-resistant infections,…”
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CotH3 mediates fungal invasion of host cells during mucormycosis by Gebremariam, Teclegiorgis, Liu, Mingfu, Luo, Guanpingsheng, Bruno, Vincent, Phan, Quynh T, Waring, Alan J, Edwards, Jr, John E, Filler, Scott G, Yeaman, Michael R, Ibrahim, Ashraf S

“…Angioinvasion is a hallmark of mucormycosis. Previously, we identified endothelial cell glucose-regulated protein 78 (GRP78) as a receptor for Mucorales that…”
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PCR-Based Approach Targeting Mucorales-Specific Gene Family for Diagnosis of Mucormycosis by Baldin, Clara, Soliman, Sameh S M, Jeon, Heewon H, Alkhazraji, Sondus, Gebremariam, Teclegiorgis, Gu, Yiyou, Bruno, Vincent M, Cornely, Oliver A, Leather, Helen L, Sugrue, Michele W, Wingard, John R, Stevens, David A, Edwards, Jr, John E, Ibrahim, Ashraf S

“…Mucormycosis is an aggressive, life-threatening infection caused by fungi in the order Mucorales. The current diagnosis of mucormycosis relies on mycological…”
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NDV-3, a recombinant alum-adjuvanted vaccine for Candida and Staphylococcus aureus , is safe and immunogenic in healthy adults by Schmidt, Clint S, White, C. Jo, Ibrahim, Ashraf S, Filler, Scott G, Fu, Yue, Yeaman, Michael R, Edwards Jr., John E, Hennessey Jr., John P

“…Highlights ► NDV-3 is safe and generally well-tolerated in healthy adults. ► NDV-3 elicits quick and robust B- and T-cell immune responses. ► A single dose…”
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The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice by Liu, Mingfu, Spellberg, Brad, Phan, Quynh T, Fu, Yue, Fu, Yong, Lee, Amy S, Edwards, Jr, John E, Filler, Scott G, Ibrahim, Ashraf S

“…Mucormycosis is a fungal infection of the sinuses, brain, or lungs that causes a mortality rate of at least 50% despite first-line therapy. Because…”
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Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells by Phan, Quynh T, Myers, Carter L, Fu, Yue, Sheppard, Donald C, Yeaman, Michael R, Welch, William H, Ibrahim, Ashraf S, Edwards, Jr, John E, Filler, Scott G

“…Candida albicans is the most common cause of hematogenously disseminated and oropharyngeal candidiasis. Both of these diseases are characterized by fungal…”
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high affinity iron permease is a key virulence factor required for Rhizopus oryzae pathogenesis by Ibrahim, Ashraf S, Gebremariam, Teclegiorgis, Lin, Lin, Luo, Guanpingsheng, Husseiny, Mohamed I, Skory, Christopher D, Fu, Yue, French, Samuel W, Edwards, John E. Jr, Spellberg, Brad

“…Rhizopus oryzae is the most common cause of mucormycosis, an angioinvasive fungal infection that causes more then 50% mortality rate despite first-line…”
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Clinical Practice Guidelines for the Management Candidiasis: 2009 Update by the Infectious Diseases Society of America by Pappas, Peter G., Kauffman, Carol A., Andes, David, Benjamin, Daniel K., Calandra, Thierry F., Edwards, John E., Filler, Scott G., Fisher, John F., Kullberg, Bart-Jan, Zeichner, Luis Ostrosky, Reboli, Annette C., Rex, John H., Walsh, Thomas J., Sobe, Jack D.

“…Guidelines for the management of patients with invasive candidiasis and mucosal candidiasis were prepared by an Expert Panel of the Infectious Diseases Society…”
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Fob1 and Fob2 Proteins Are Virulence Determinants of Rhizopus oryzae via Facilitating Iron Uptake from Ferrioxamine by Liu, Mingfu, Lin, Lin, Gebremariam, Teclegiorgis, Luo, Guanpingsheng, Skory, Christopher D, French, Samuel W, Chou, Tsui-Fen, Edwards, Jr, John E, Ibrahim, Ashraf S

“…Dialysis patients with chronic renal failure receiving deferoxamine for treating iron overload are uniquely predisposed for mucormycosis, which is most often…”
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the hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin by Almeida, Ricardo S, Brunke, Sascha, Albrecht, Antje, Thewes, Sascha, Laue, Michael, Edwards, John E, Filler, Scott G, Hube, Bernhard

“…Iron sequestration by host iron-binding proteins is an important mechanism of resistance to microbial infections. Inside oral epithelial cells, iron is stored…”
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The iron chelator deferasirox protects mice from mucormycosis through iron starvation by Ibrahim, Ashraf S, Gebermariam, Teclegiorgis, Fu, Yue, Lin, Lin, Husseiny, Mohamed I, French, Samuel W, Schwartz, Julie, Skory, Christopher D, Edwards, Jr, John E, Spellberg, Brad J

“…Mucormycosis causes mortality in at least 50% of cases despite current first-line therapies. Clinical and animal data indicate that the presence of elevated…”
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An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris by Iyer, Kali R., Camara, Kaddy, Daniel-Ivad, Martin, Trilles, Richard, Pimentel-Elardo, Sheila M., Fossen, Jen L., Marchillo, Karen, Liu, Zhongle, Singh, Shakti, Muñoz, José F., Kim, Sang Hu, Porco, John A., Cuomo, Christina A., Williams, Noelle S., Ibrahim, Ashraf S., Edwards, John E., Andes, David R., Nodwell, Justin R., Brown, Lauren E., Whitesell, Luke, Robbins, Nicole, Cowen, Leah E.

“…Candida auris is an emerging fungal pathogen that exhibits resistance to multiple drugs, including the most commonly prescribed antifungal, fluconazole. Here,…”
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Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo by Nobile, Clarissa J, Andes, David R, Nett, Jeniel E, Smith, Frank J, Yue, Fu, Phan, Quynh-Trang, Edwards, John E, Filler, Scott G, Mitchell, Aaron P

“…The fungal pathogen Candida albicans is frequently associated with catheter-based infections because of its ability to form resilient biofilms. Prior studies…”
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The Hyr1 protein from the fungus Candida albicans is a cross kingdom immunotherapeutic target for Acinetobacter bacterial infection by Uppuluri, Priya, Lin, Lin, Alqarihi, Abdullah, Luo, Guanpingsheng, Youssef, Eman G, Alkhazraji, Sondus, Yount, Nannette Y, Ibrahim, Belal A, Bolaris, Michael Anthony, Edwards, Jr, John E, Swidergall, Marc, Filler, Scott G, Yeaman, Michael R, Ibrahim, Ashraf S

“…Different pathogens share similar medical settings and rely on similar virulence strategies to cause infections. We have previously applied 3-D computational…”
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Combination Echinocandin-Polyene Treatment of Murine Mucormycosis by Ibrahim, Ashraf S, Gebremariam, Teclegiorgis, Fu, Yue, Edwards, Jr, John E, Spellberg, Brad

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Antifungal Vaccine Derived from the Recombinant N Terminus of Als3p Protects Mice against the Bacterium Staphylococcus aureus by Spellberg, Brad, Ibrahim, Ashraf S, Yeaman, Michael R, Lin, Lin, Fu, Yue, Avanesian, Valentina, Bayer, Arnold S, Filler, Scott G, Lipke, Peter, Otoo, Henry, Edwards, John E. Jr

“…Vaccination with the recombinant N terminus of the candidal adhesin Als3p (rAls3p-N) protects mice from lethal candidemia. Candidal Als3p also is structurally…”
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