Search Results - "Edwards, Donna M"

A Barth Syndrome Patient-Derived D75H Point Mutation in TAFAZZIN Drives Progressive Cardiomyopathy in Mice by Snider, Paige L, Sierra Potchanant, Elizabeth A, Sun, Zejin, Edwards, Donna M, Chan, Ka-Kui, Matias, Catalina, Awata, Junya, Sheth, Aditya, Pride, P Melanie, Payne, R Mark, Rubart, Michael, Brault, Jeffrey J, Chin, Michael T, Nalepa, Grzegorz, Conway, Simon J

“…Cardiomyopathy is the predominant defect in Barth syndrome (BTHS) and is caused by a mutation of the X-linked gene, which encodes an enzyme responsible for…”
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Pan‐Cancer Survival Impact of Immune Checkpoint Inhibitors in a National Healthcare System by Miller, Sean R., Schipper, Matthew, Fritsche, Lars G., Jiang, Ralph, Strohbehn, Garth, Ötleş, Erkin, McMahon, Benjamin H., Crivelli, Silvia, Zamora‐Resendiz, Rafael, Ramnath, Nithya, Yoo, Shinjae, Dai, Xin, Sankar, Kamya, Edwards, Donna M., Allen, Steven G., Green, Michael D., Bryant, Alex K.

“…ABSTRACT Background The cumulative, health system‐wide survival benefit of immune checkpoint inhibitors (ICIs) is unclear, particularly among real‐world…”
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SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA‐deficient cells by Chan, Ka‐Kui, Abdul‐Sater, Zahi, Sheth, Aditya, Mitchell, Dana K., Sharma, Richa, Edwards, Donna M., He, Ying, Nalepa, Grzegorz, Rhodes, Steven D., Clapp, D. Wade, Sierra Potchanant, Elizabeth A.

“…The Fanconi anemia (FA) pathway safeguards genomic stability through cell cycle regulation and DNA damage repair. The canonical tumor suppressive role of FA…”
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Mitotic Errors Promote Genomic Instability and Leukemia in a Novel Mouse Model of Fanconi Anemia by Edwards, Donna M., Mitchell, Dana K., Abdul-Sater, Zahi, Chan, Ka-Kui, Sun, Zejin, Sheth, Aditya, He, Ying, Jiang, Li, Yuan, Jin, Sharma, Richa, Czader, Magdalena, Chin, Pei-Ju, Liu, Yie, de Cárcer, Guillermo, Nalepa, Grzegorz, Broxmeyer, Hal E., Clapp, D. Wade, Sierra Potchanant, Elizabeth A.

“…Fanconi anemia (FA) is a disease of genomic instability and cancer. In addition to DNA damage repair, FA pathway proteins are now known to be critical for…”
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Targeting Noncanonical Regulators of the DNA Damage Response to Selectively Overcome Cancer Radiation Resistance by Edwards, Donna M., Speers, Corey, Wahl, Daniel R.

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Impact of lung cancer screening on stage migration and mortality among the national Veterans Health Administration population with lung cancer by Edwards, Donna M., Pirzadeh, Mina, Van, Tony, Jiang, Ralph, Tate, Akshay, Schaefer, Grace, James, Jadyn, Bishop, Caroline, Wilson, Cydnee, Nedzesky, Nicholas, Alseri, Aaren, Leveque, Anthony, Malus, Amanda, Waljee, Akbar, Elliott, David A., Deng, Jane, Schwartz, Ann, Schipper, Matthew, Bryant, Alex K., Ramnath, Nithya, Green, Michael D.

“…Background Despite randomized trials demonstrating a mortality benefit to low‐dose computed tomography screening to detect lung cancer, uptake of lung cancer…”
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Pneumonitis After Chemoradiotherapy and Adjuvant Durvalumab in Stage III Non-Small Cell Lung Cancer by Edwards, Donna M., Sankar, Kamya, Alseri, Aaren, Jiang, Ralph, Schipper, Matthew, Miller, Sean, Dess, Kathryn, Strohbehn, Garth W., Elliott, David A., Moghanaki, Drew, Ramnath, Nithya, Green, Michael D., Bryant, Alex K.

“…Adjuvant durvalumab after definitive chemoradiotherapy (CRT) for unresectable stage III non-small cell lung cancer (NSCLC) is well-tolerated in clinical…”
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Follow‐up for human papillomavirus‐related oropharynx cancer concentrated on unequal symptom change (FOCUS): Prospective patient‐reported outcome collection by Edwards, Donna M., Gharzai, Laila A., Wang, Weilin, Mayo, Charles, Suresh, Krithika, Schipper, Matthew, Evans, Joseph R., Malloy, Kelly, Chinn, Steven B., Prince, Mark, Spector, Matthew, Shuman, Andrew, Stucken, Chaz, Swiecicki, Paul L., Worden, Francis, Jarema, Jennifer, Henderson, Caitlin, Kovach, Amanda, Brenner, Chad, Shah, Jennifer L., Mierzwa, Michelle L., Casper, Keith

“…Background Post‐treatment surveillance recommendations for oropharyngeal cancer do not vary with p16 status despite the differences in outcomes. The optimal…”
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Phase 2 Trial Assessing Toxicity of Personalized Response-Based Radiation Treatment in Patients With Locally Advanced Non-Small Cell Lung Cancer by Edwards, Donna M., Schonewolf, Caitlin A., Rice, John D., Schipper, Matthew, Haken, Randall K. Ten, Matuszak, Martha, Balter, James, Jarema, David, Arenberg, Douglas A., Piert, Morand, Qin, Angel, Kalemkerian, Gregory P., Schneider, Bryan J., Ramnath, Nithya, Chapman, Christina H., Elliott, David A., Lawrence, Theodore S., Hearn, Jason, Hayman, James A., Jolly, Shruti

“…Local failure rates after treatment for locally advanced non–small cell lung cancer (NSCLC) remain high. Efforts to improve local control with a uniform dose…”
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Adopting Weight-Based Dosing With Pharmacy-Level Stewardship Strategies Could Reduce Cancer Drug Spending By Millions by Bryant, Alex K, Chopra, Zoey, Edwards, Donna M, Whalley, Adam S, Bazzell, Brian G, Moeller, Julie A, Kelley, Michael J, Fendrick, A Mark, Kerr, Eve A, Ramnath, Nithya, Green, Michael D, Hofer, Timothy P, Strohbehn, Garth W

“…Immune checkpoint inhibitors, a class of drugs used in approximately forty unique cancer indications, are a sizable component of the economic burden of cancer…”
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Metabolomic Profiles of Human Glioma Inform Patient Survival by Scott, Andrew J, Correa, Luis O, Edwards, Donna M, Sun, Yilun, Ravikumar, Visweswaran, Andren, Anthony C, Zhang, Li, Srinivasan, Sudharsan, Jairath, Neil, Verbal, Kait, Muraszko, Karin, Sagher, Oren, Carty, Shannon A, Hervey-Jumper, Shawn, Orringer, Daniel, Kim, Michelle M, Junck, Larry, Umemura, Yoshie, Leung, Denise, Venneti, Sriram, Camelo-Piragua, Sandra, Lawrence, Theodore S, Ippolito, Joseph E, Al-Holou, Wajd N, Chinnaiyan, Prakash, Heth, Jason, Rao, Arvind, Lyssiotis, Costas A, Wahl, Daniel R

“…Targeting tumor metabolism may improve the outcomes for patients with glioblastoma (GBM). To further preclinical efforts targeting metabolism in GBM, we tested…”
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Cannabis Use in Patients Seen in an Academic Radiation Oncology Department by Cousins, Matthew M., Mayo, Chuck, Devasia, Theresa, Dykstra, Michael, Regan, Samuel, Miller, Sean, Allen, Steven G., Bryant, Alex K., Morales-Rivera, Krystal, Herr, Daniel J., Edwards, Donna M., Takayesu, Jamie, Birer, Samuel, Egerer, Nancy, Evans, Joseph, Elliott, David, Henderson, Caitlin, Laucis, Anna M., McFarlane, Matthew, Dragovic, Aleksandar F., Shah, Jennifer, Hayman, James A., Coughlin, Lara N., Ilgen, Mark, Jagsi, Reshma

“…Cannabis use rates are increasing in the United States. Patients with cancer use cannabis for many reasons, even without high-quality supporting data. This…”
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Parametric analysis of technology and policy tradeoffs for conventional and electric light-duty vehicles by Barter, Garrett E., Reichmuth, David, Westbrook, Jessica, Malczynski, Leonard A., West, Todd H., Manley, Dawn K., Guzman, Katherine D., Edwards, Donna M.

“…A parametric analysis is used to examine the supply demand interactions between the US light-duty vehicle (LDV) fleet, its fuels, and the corresponding primary…”
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Effectiveness and safety of immune checkpoint inhibitors in Black patients versus White patients in a US national health system: a retrospective cohort study by Miller, Sean, Jiang, Ralph, Schipper, Matthew, Fritsche, Lars G, Strohbehn, Garth, Wallace, Beth, Brinzevich, Daria, Falvello, Virginia, McMahon, Benjamin H, Zamora-Resendiz, Rafael, Ramnath, Nithya, Dai, Xin, Sankar, Kamya, Edwards, Donna M, Allen, Steven G, Yoo, Shinjae, Crivelli, Silvia, Green, Michael D, Bryant, Alex K

“…Black patients were severely under-represented in the clinical trials that led to the approval of immune checkpoint inhibitors (ICIs) for all cancers. The aim…”
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Adopting Weight-Based Dosing With Pharmacy-Level Stewardship Strategies Could Reduce Cancer Drug Spending By Millions: Study examines possible savings from adopting weight-based dosing for certain cancer drugs by Bryant, Alex K., Chopra, Zoey, Edwards, Donna M., Whalley, Adam S., Bazzell, Brian G., Moeller, Julie A., Kelley, Michael J., Fendrick, A. Mark, Kerr, Eve A., Ramnath, Nithya, Green, Michael D., Hofer, Timothy P., Strohbehn, Garth W.

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Phase II Trial Assessing Toxicity of Personalized Response-Based Radiation Treatment in Patients with Locally Advanced Non-Small Cell Lung Cancer by Edwards, Donna M, Schonewolf, Caitlin A, Rice, John D, Schipper, Matthew, Haken, Randall K Ten, Matuszak, Martha, Balter, James, Jarema, David, Arenberg, Douglas A, Piert, Morand, Qin, Angel, Kalemkerian, Gregory P, Schneider, Bryan J, Ramnath, Nithya, Chapman, Christina H, Elliott, David A, Lawrence, Theodore S, Hearn, Jason, Hayman, James A, Jolly, Shruti

“…Local failure rates after treatment for locally advanced non-small-cell lung cancer (NSCLC) remain high. Efforts to improve local control with uniform…”
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Abstract 1801: Rewiring of cortical glucose metabolism fuels human brain cancer growth by Scott, Andrew J., Mittal, Anjali, Meghdadi, Baharan, Palavalasa, Sravya, Achreja, Abhinav, O'Brien, Alexandra, Kothari, Ayesha, Zhou, Weihua, Xu, Jie, Lin, Angelica, Wilder-Romans, Kari, Edwards, Donna M., Tarnal, Vijay, Qi, Nathan, Lawrence, Theodore S., Venneti, Sriram, Agar, Nathalie Y., Lyssiotis, Costas A., Al-Holou, Wajd N., Nagrath, Deepak, Wahl, Daniel R.

“…Abstract The brain avidly consumes glucose to fuel neurophysiology. Cancers of the brain, such as glioblastoma (GBM), lose aspects of normal biology and gain…”
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Folate analogs. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogs of N10-propargyl-5,8-dideazafolic acid by Li, Shu Wen, Nair, M. G, Edwards, Donna M, Kisliuk, R. L, Gaumont, Y, Dev, I. K, Duch, D. S, Humphreys, J, Smith, G. K, Ferone, Robert

“…Structural modifications at the pyrimidine ring and at the C9,N10-bridge region of the thymidylate synthase (TS) inhibitors N10-propargyl-5,8-dideazafolate (1;…”
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A Dynamic HIV-Transmission Model for Evaluating the Costs and Benefits of Vaccine Programs by Edwards, Donna M, Shachter, Ross D, Owens, Douglas K

“…We developed a dynamic model of HIV transmission to evaluate the costs and benefits of HIV-vaccine programs in a population of homosexual men. We examined how…”
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D91. Effect of Pre-pectoral Versus Sub-pectoral Implant Placement in Breast Reconstruction on the Delivery of Post-mastectomy Radiation by Baglien, Brigit D., Takayesu, Jamie, Edwards, Donna, Matusko, Niki, Speers, Corey, Momoh, Adeyiza

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