Search Results - "Edwards, Donna"

Targeting Noncanonical Regulators of the DNA Damage Response to Selectively Overcome Cancer Radiation Resistance by Edwards, Donna M., Speers, Corey, Wahl, Daniel R.

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Impact of lung cancer screening on stage migration and mortality among the national Veterans Health Administration population with lung cancer by Edwards, Donna M., Pirzadeh, Mina, Van, Tony, Jiang, Ralph, Tate, Akshay, Schaefer, Grace, James, Jadyn, Bishop, Caroline, Wilson, Cydnee, Nedzesky, Nicholas, Alseri, Aaren, Leveque, Anthony, Malus, Amanda, Waljee, Akbar, Elliott, David A., Deng, Jane, Schwartz, Ann, Schipper, Matthew, Bryant, Alex K., Ramnath, Nithya, Green, Michael D.

“…Background Despite randomized trials demonstrating a mortality benefit to low‐dose computed tomography screening to detect lung cancer, uptake of lung cancer…”
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Pneumonitis After Chemoradiotherapy and Adjuvant Durvalumab in Stage III Non-Small Cell Lung Cancer by Edwards, Donna M., Sankar, Kamya, Alseri, Aaren, Jiang, Ralph, Schipper, Matthew, Miller, Sean, Dess, Kathryn, Strohbehn, Garth W., Elliott, David A., Moghanaki, Drew, Ramnath, Nithya, Green, Michael D., Bryant, Alex K.

“…Adjuvant durvalumab after definitive chemoradiotherapy (CRT) for unresectable stage III non-small cell lung cancer (NSCLC) is well-tolerated in clinical…”
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A Barth Syndrome Patient-Derived D75H Point Mutation in TAFAZZIN Drives Progressive Cardiomyopathy in Mice by Snider, Paige L, Sierra Potchanant, Elizabeth A, Sun, Zejin, Edwards, Donna M, Chan, Ka-Kui, Matias, Catalina, Awata, Junya, Sheth, Aditya, Pride, P Melanie, Payne, R Mark, Rubart, Michael, Brault, Jeffrey J, Chin, Michael T, Nalepa, Grzegorz, Conway, Simon J

“…Cardiomyopathy is the predominant defect in Barth syndrome (BTHS) and is caused by a mutation of the X-linked gene, which encodes an enzyme responsible for…”
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Treatment of Metastatic Renal Cell Carcinoma With a Combination of Bevacizumab and Erlotinib by HAINSWORTH, John D, SOSMAN, Jeffrey A, SPIGEL, David R, EDWARDS, Donna L, BAUGHMAN, Cara, GRECO, Anthony

“…To evaluate the efficacy and toxicity of combined treatment with two targeted agents, an antibody against vascular endothelial growth factor (bevacizumab) and…”
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Follow‐up for human papillomavirus‐related oropharynx cancer concentrated on unequal symptom change (FOCUS): Prospective patient‐reported outcome collection by Edwards, Donna M., Gharzai, Laila A., Wang, Weilin, Mayo, Charles, Suresh, Krithika, Schipper, Matthew, Evans, Joseph R., Malloy, Kelly, Chinn, Steven B., Prince, Mark, Spector, Matthew, Shuman, Andrew, Stucken, Chaz, Swiecicki, Paul L., Worden, Francis, Jarema, Jennifer, Henderson, Caitlin, Kovach, Amanda, Brenner, Chad, Shah, Jennifer L., Mierzwa, Michelle L., Casper, Keith

“…Background Post‐treatment surveillance recommendations for oropharyngeal cancer do not vary with p16 status despite the differences in outcomes. The optimal…”
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Phase 2 Trial Assessing Toxicity of Personalized Response-Based Radiation Treatment in Patients With Locally Advanced Non-Small Cell Lung Cancer by Edwards, Donna M., Schonewolf, Caitlin A., Rice, John D., Schipper, Matthew, Haken, Randall K. Ten, Matuszak, Martha, Balter, James, Jarema, David, Arenberg, Douglas A., Piert, Morand, Qin, Angel, Kalemkerian, Gregory P., Schneider, Bryan J., Ramnath, Nithya, Chapman, Christina H., Elliott, David A., Lawrence, Theodore S., Hearn, Jason, Hayman, James A., Jolly, Shruti

“…Local failure rates after treatment for locally advanced non–small cell lung cancer (NSCLC) remain high. Efforts to improve local control with a uniform dose…”
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Adopting Weight-Based Dosing With Pharmacy-Level Stewardship Strategies Could Reduce Cancer Drug Spending By Millions by Bryant, Alex K, Chopra, Zoey, Edwards, Donna M, Whalley, Adam S, Bazzell, Brian G, Moeller, Julie A, Kelley, Michael J, Fendrick, A Mark, Kerr, Eve A, Ramnath, Nithya, Green, Michael D, Hofer, Timothy P, Strohbehn, Garth W

“…Immune checkpoint inhibitors, a class of drugs used in approximately forty unique cancer indications, are a sizable component of the economic burden of cancer…”
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Metabolomic Profiles of Human Glioma Inform Patient Survival by Scott, Andrew J, Correa, Luis O, Edwards, Donna M, Sun, Yilun, Ravikumar, Visweswaran, Andren, Anthony C, Zhang, Li, Srinivasan, Sudharsan, Jairath, Neil, Verbal, Kait, Muraszko, Karin, Sagher, Oren, Carty, Shannon A, Hervey-Jumper, Shawn, Orringer, Daniel, Kim, Michelle M, Junck, Larry, Umemura, Yoshie, Leung, Denise, Venneti, Sriram, Camelo-Piragua, Sandra, Lawrence, Theodore S, Ippolito, Joseph E, Al-Holou, Wajd N, Chinnaiyan, Prakash, Heth, Jason, Rao, Arvind, Lyssiotis, Costas A, Wahl, Daniel R

“…Targeting tumor metabolism may improve the outcomes for patients with glioblastoma (GBM). To further preclinical efforts targeting metabolism in GBM, we tested…”
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PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2) by Hawley, Eric, Gehlhausen, Jeffrey, Karchugina, Sofiia, Chow, Hoi-Yee, Araiza-Olivera, Daniela, Radu, Maria, Smith, Abbi, Burks, Ciersten, Jiang, Li, Li, Xiaohong, Bessler, Waylan, Masters, Andrea, Edwards, Donna, Burgin, Callie, Jones, David, Yates, Charles, Clapp, D Wade, Chernoff, Jonathan, Park, Su-Jung

“…Abstract Neurofibromatosis Type II (NF2) is an autosomal dominant cancer predisposition syndrome in which germline haploinsufficiency at the NF2 gene confers a…”
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PRL-3 increases the aggressive phenotype of prostate cancer cells in vitro and its expression correlates with high-grade prostate tumors in patients by Edwards, Donna R, Moroz, Krzysztof, Zhang, Haitao, Mulholland, David, Abdel-Mageed, Asim B, Mondal, Debasis

“…The increased expression of phosphatase of regenerating liver-3 (PRL-3) has been shown to be associated with the aggressive and metastatic phenotype of…”
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Pan‐Cancer Survival Impact of Immune Checkpoint Inhibitors in a National Healthcare System by Miller, Sean R., Schipper, Matthew, Fritsche, Lars G., Jiang, Ralph, Strohbehn, Garth, Ötleş, Erkin, McMahon, Benjamin H., Crivelli, Silvia, Zamora‐Resendiz, Rafael, Ramnath, Nithya, Yoo, Shinjae, Dai, Xin, Sankar, Kamya, Edwards, Donna M., Allen, Steven G., Green, Michael D., Bryant, Alex K.

“…ABSTRACT Background The cumulative, health system‐wide survival benefit of immune checkpoint inhibitors (ICIs) is unclear, particularly among real‐world…”
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SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA‐deficient cells by Chan, Ka‐Kui, Abdul‐Sater, Zahi, Sheth, Aditya, Mitchell, Dana K., Sharma, Richa, Edwards, Donna M., He, Ying, Nalepa, Grzegorz, Rhodes, Steven D., Clapp, D. Wade, Sierra Potchanant, Elizabeth A.

“…The Fanconi anemia (FA) pathway safeguards genomic stability through cell cycle regulation and DNA damage repair. The canonical tumor suppressive role of FA…”
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Mitotic Errors Promote Genomic Instability and Leukemia in a Novel Mouse Model of Fanconi Anemia by Edwards, Donna M., Mitchell, Dana K., Abdul-Sater, Zahi, Chan, Ka-Kui, Sun, Zejin, Sheth, Aditya, He, Ying, Jiang, Li, Yuan, Jin, Sharma, Richa, Czader, Magdalena, Chin, Pei-Ju, Liu, Yie, de Cárcer, Guillermo, Nalepa, Grzegorz, Broxmeyer, Hal E., Clapp, D. Wade, Sierra Potchanant, Elizabeth A.

“…Fanconi anemia (FA) is a disease of genomic instability and cancer. In addition to DNA damage repair, FA pathway proteins are now known to be critical for…”
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Cannabis Use in Patients Seen in an Academic Radiation Oncology Department by Cousins, Matthew M., Mayo, Chuck, Devasia, Theresa, Dykstra, Michael, Regan, Samuel, Miller, Sean, Allen, Steven G., Bryant, Alex K., Morales-Rivera, Krystal, Herr, Daniel J., Edwards, Donna M., Takayesu, Jamie, Birer, Samuel, Egerer, Nancy, Evans, Joseph, Elliott, David, Henderson, Caitlin, Laucis, Anna M., McFarlane, Matthew, Dragovic, Aleksandar F., Shah, Jennifer, Hayman, James A., Coughlin, Lara N., Ilgen, Mark, Jagsi, Reshma

“…Cannabis use rates are increasing in the United States. Patients with cancer use cannabis for many reasons, even without high-quality supporting data. This…”
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The development and use of decision support framework for informing selection of select agent toxins with modelling studies to inform permissible toxin amounts by Pillai, Segaran P., West, Todd, Levinson, Rebecca, Fruetel, Julia A., Anderson, Kevin, Edwards, Donna, Morse, Stephen A.

“…Many countries have worked diligently to establish and implement policies and processes to regulate high consequence pathogens and toxins that could have a…”
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D91. Effect of Pre-pectoral Versus Sub-pectoral Implant Placement in Breast Reconstruction on the Delivery of Post-mastectomy Radiation by Baglien, Brigit D., Takayesu, Jamie, Edwards, Donna, Matusko, Niki, Speers, Corey, Momoh, Adeyiza

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Patient Electronic Health Records Score for Preoperative Risk Assessment Before Total Knee Arthroplasty by Osborne, Thomas F, Suarez, Paola, Edwards, Donna, Hernandez-Boussard, Tina, Curtin, Catherine

“…Current preoperative risk assessment tools are often cumbersome, have limited accuracy, and are poorly adopted. The Care Assessment Need (CAN) score, an…”
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Parametric analysis of technology and policy tradeoffs for conventional and electric light-duty vehicles by Barter, Garrett E., Reichmuth, David, Westbrook, Jessica, Malczynski, Leonard A., West, Todd H., Manley, Dawn K., Guzman, Katherine D., Edwards, Donna M.

“…A parametric analysis is used to examine the supply demand interactions between the US light-duty vehicle (LDV) fleet, its fuels, and the corresponding primary…”
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Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy by Cerra-Franco, Alberto, Liu, Sheng, Azar, Michella, Shiue, Kevin, Freije, Samantha, Hinton, Jason, Deig, Christopher R., Edwards, Donna, Estabrook, Neil C., Ellsworth, Susannah G., Huang, Ke, Diab, Khalil, Langer, Mark P., Zellars, Richard, Kong, Feng-Ming, Wan, Jun, Lautenschlaeger, Tim

“…Many patients with early stage non–small-cell lung cancer (ES-NSCLC) undergoing stereotactic body radiation therapy (SBRT) develop metastases, which is…”
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