Measurement of the Flux of Lead from Bone to Blood in a Nonhuman Primate (Macaca fascicularis) by Sequential Administration of Stable Lead Isotopes

Measurement of the Flux of Lead from Bone to Blood in a Nonhuman Primate (Macaca fascicularis) by Sequential Administration of Stable Lead Isotopes

To better understand the kinetics of the transfer of lead from bone to blood, we have developed and tested a method in which sequential doses of lead, each enriched with a different stable isotope, were administered in a nonhuman primateMacaca fasciculariswhose skeleton had been previously labeled w...

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Bibliographic Details
Published in:Fundamental and applied toxicology Vol. 33; no. 2; pp. 235 - 245
Main Authors: Inskip, M.J., Franklin, C.A., Baccanale, C.L., Manton, W.I., O'flaherty, E.J., Edwards, C.M.H., Blenkinsop, J.B., Edwards, E.B.
Format: Journal Article
Language:English
Published: Boston, MA Elsevier Science (USA) 01-10-1996
San Diego, CA Academic Press
New York, NY
Subjects:
Animals
Biological and medical sciences
Biological Transport
Bone and Bones - metabolism
Chemical and industrial products toxicology. Toxic occupational diseases
Female
Isotopes
Lead - blood
Lead - pharmacokinetics
Macaca fascicularis
Mass Spectrometry - methods
Medical sciences
Pregnancy
Solvents
Toxicology
Oral administration
Macaca fascicularis
Heavy metal
Whole blood
Toxicokinetics
Vertebrata
Mammalia
Animal
Distribution
Primates
Simioidea
Lead
Kinetics
Bone
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Summary:To better understand the kinetics of the transfer of lead from bone to blood, we have developed and tested a method in which sequential doses of lead, each enriched with a different stable isotope, were administered in a nonhuman primateMacaca fasciculariswhose skeleton had been previously labeled with lead of known isotopic composition. Lead isotopic ratios of blood and bone samples, analyzed by thermal ionization mass spectrometry (TIMS), were unmixed by isotope dilution techniques. The first label administered allows the contribution from historical bone stores to be measured. Subsequent labels allow measurement of both the historical bone stores and the previous labels that have become recently incorporated into bone. The method may be extended to studies of bone lead mobilization in pregnancy, lactation, menopause, or in disease states such as postmenopausal osteoporosis.
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ISSN:0272-0590
1095-6832
DOI:10.1006/faat.1996.0161