Search Results - "Edwards, Bruce"

Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance by Sully, Erin K, Malachowa, Natalia, Elmore, Bradley O, Alexander, Susan M, Femling, Jon K, Gray, Brian M, DeLeo, Frank R, Otto, Michael, Cheung, Ambrose L, Edwards, Bruce S, Sklar, Larry A, Horswill, Alexander R, Hall, Pamela R, Gresham, Hattie D

“…Bacterial signaling systems are prime drug targets for combating the global health threat of antibiotic resistant bacterial infections including those caused…”
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Flow Cytometry: Impact on Early Drug Discovery by Edwards, Bruce S, Sklar, Larry A

“…Modern flow cytometers can make optical measurements of 10 or more parameters per cell at tens of thousands of cells per second and more than five orders of…”
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Effectiveness of Laser Application for Periodontal Surgical Therapy: Systematic Review and Meta‐Analysis by Behdin, Shabnam, Monje, Alberto, Lin, Guo‐Hao, Edwards, Bruce, Othman, Abdullah, Wang, Hom‐Lay

“…Background: Evidence has shown some improved clinical outcomes and morbidity reduction with the use of lasers for non‐surgical periodontal therapy due to…”
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Line-Focused Optical Excitation of Parallel Acoustic Focused Sample Streams for High Volumetric and Analytical Rate Flow Cytometry by Kalb, Daniel M, Fencl, Frank A, Woods, Travis A, Swanson, August, Maestas, Gian C, Juárez, Jaime J, Edwards, Bruce S, Shreve, Andrew P, Graves, Steven W

“…Flow cytometry provides highly sensitive multiparameter analysis of cells and particles but has been largely limited to the use of a single focused sample…”
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Virtual and biomolecular screening converge on a selective agonist for GPR30 by Oprea, Tudor I, Prossnitz, Eric R, Bologa, Cristian G, Revankar, Chetana M, Young, Susan M, Edwards, Bruce S, Arterburn, Jeffrey B, Kiselyov, Alexander S, Parker, Matthew A, Tkachenko, Sergey E, Savchuck, Nikolay P, Sklar, Larry A

“…Estrogen is a hormone critical in the development, normal physiology and pathophysiology of numerous human tissues. The effects of estrogen have traditionally…”
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Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters by Strouse, J. Jacob, Ivnitski-Steele, Irena, Waller, Anna, Young, Susan M., Perez, Dominique, Evangelisti, Annette M., Ursu, Oleg, Bologa, Cristian G., Carter, Mark B., Salas, Virginia M., Tegos, George, Larson, Richard S., Oprea, Tudor I., Edwards, Bruce S., Sklar, Larry A.

“…ATP binding cassette (ABC) transmembrane efflux pumps such as P-glycoprotein (ABCB1), multidrug resistance protein 1 (ABCC1), and breast cancer resistance…”
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Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening by Hill, Jeff W, Thompson, Jeffrey F, Carter, Mark B, Edwards, Bruce S, Sklar, Larry A, Rosenberg, Gary A

“…Stroke is a leading cause of death and disability and treatment options are limited. A promising approach to accelerate the development of new therapeutics is…”
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High-Throughput Flow Cytometry in Drug Discovery by Ding, Mei, Edwards, Bruce S

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Flow cytometry for high-throughput, high-content screening by Edwards, Bruce S, Oprea, Tudor, Prossnitz, Eric R, Sklar, Larry A

“…Flow cytometry is a mature platform for quantitative multi-parameter measurement of cell fluorescence. Recent innovations allow up to 30-fold faster serial…”
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Drug repurposing from an academic perspective by Oprea, Tudor I, Bauman, Julie E, Bologa, Cristian G, Buranda, Tione, Chigaev, Alexandre, Edwards, Bruce S, Jarvik, Jonathan W, Gresham, Hattie D, Haynes, Mark K, Hjelle, Brian, Hromas, Robert, Hudson, Laurie, Mackenzie, Debra A, Muller, Carolyn Y, Reed, John C, Simons, Peter C, Smagley, Yelena, Strouse, Juan, Surviladze, Zurab, Thompson, Todd, Ursu, Oleg, Waller, Anna, Wandinger-Ness, Angela, Winter, Stuart S, Wu, Yang, Young, Susan M, Larson, Richard S, Willman, Cheryl, Sklar, Larry A

“…Academia and small business research units are poised to play an increasing role in drug discovery, with drug repurposing as one of the major areas of…”
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The proteomics of quiescent and nonquiescent cell differentiation in yeast stationary-phase cultures by Davidson, George S, Joe, Ray M, Roy, Sushmita, Meirelles, Osorio, Allen, Chris P, Wilson, Melissa R, Tapia, Phillip H, Manzanilla, Elaine E, Dodson, Anne E, Chakraborty, Swagata, Carter, Mark, Young, Susan, Edwards, Bruce, Sklar, Larry, Werner-Washburne, Margaret

“…As yeast cultures enter stationary phase in rich, glucose-based medium, differentiation of two major subpopulations of cells, termed quiescent and…”
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A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions by Barrett, David, Wyatt, Meghan, Bar, Haim, Haynes, Mark K., Edwards, Bruce S., Sklar, Larry A., Zweifach, Adam

“…The solid tumor microenvironment (TME) suppresses immune responses. Three alterations in the TME converge on a pathway triggered by elevated cyclic AMP (cAMP)…”
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Elastomeric Negative Acoustic Contrast Particles for Affinity Capture Assays by Cushing, Kevin W, Piyasena, Menake E, Carroll, Nick J, Maestas, Gian C, López, Beth Ann, Edwards, Bruce S, Graves, Steven W, López, Gabriel P

“…This report describes the development of elastomeric capture microparticles (ECμPs) and their use with acoustophoretic separation to perform microparticle…”
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The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors by Santos, Radleigh G, Appel, Jon R, Giulianotti, Marc A, Edwards, Bruce S, Sklar, Larry A, Houghten, Richard A, Pinilla, Clemencia

“…In the past 20 years, synthetic combinatorial methods have fundamentally advanced the ability to synthesize and screen large numbers of compounds for drug…”
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The University of New Mexico Center for Molecular Discovery by Edwards, Bruce S, Gouveia, Kristine, Oprea, Tudor I, Sklar, Larry A

“…The University of New Mexico Center for Molecular Discovery (UNMCMD) is an academic research center that specializes in discovery using high throughput flow…”
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Activation of Rho Family GTPases by Small Molecules by Palsuledesai, Charuta C, Surviladze, Zurab, Waller, Anna, Miscioscia, T. Fabiola, Guo, Yuna, Wu, Yang, Strouse, Jake, Romero, Elsa, Salas, Virginia M, Curpan, Ramona, Young, Susan, Carter, Mark, Foutz, Terry, Galochkina, Zhanna, Ames, Harold, Haynes, Mark K, Edwards, Bruce S, Nicolotti, Orazio, Luo, Li, Ursu, Oleg, Bologa, Cristian G, Oprea, Tudor I, Wandinger-Ness, Angela, Sklar, Larry A

“…Ras and Ras-related small GTPases are key regulators of diverse cellular functions that impact cell growth, survival, motility, morphogenesis, and…”
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A high-throughput phenotypic screen of cytotoxic T lymphocyte lytic granule exocytosis reveals candidate immunosuppressants by Zhao, Ziyan, Haynes, Mark K, Ursu, Oleg, Edwards, Bruce S, Sklar, Larry A, Zweifach, Adam

“…We screened the National Institutes of Health's Molecular Libraries Small Molecule Repository for inhibitors of cytotoxic T lymphocyte (CTL) lytic granule…”
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Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries by Pinilla, Clemencia, Edwards, Bruce S, Appel, Jon R, Yates-Gibbins, Tina, Giulianotti, Marc A, Medina-Franco, Jose L, Young, Susan M, Santos, Radleigh G, Sklar, Larry A, Houghten, Richard A

“…The formylpeptide receptor (FPR1) and formylpeptide-like 1 receptor (FPR2) are G protein-coupled receptors that are linked to acute inflammatory responses,…”
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Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30 by Arterburn, Jeffrey B, Oprea, Tudor I, Prossnitz, Eric R, Edwards, Bruce S, Sklar, Larry A

“…Recent technological advances in flow cytometry provide a versatile platform for high throughput screening of compound libraries coupled with high-content…”
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Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay by Surviladze, Zurab, Waller, Anna, Wu, Yang, Romero, Elsa, Edwards, Bruce S, Wandinger-Ness, Angela, Sklar, Larry A

“…Small GTPases are key regulators of cellular activity and represent novel targets for the treatment of human diseases using small-molecule inhibitors. The…”
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