Search Results - "Edwards, Alison A."

To enhance dissolution rate of poorly water-soluble drugs: Glucosamine hydrochloride as a potential carrier in solid dispersion formulations by Al-Hamidi, Hiba, Edwards, Alison A., Mohammad, Mohammad A., Nokhodchi, Ali

“…The solid dispersion technique is the most effective method for improving the dissolution rate of poorly water-soluble drugs, however this is reliant on a…”
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Improved solid-phase synthesis and study of arylopeptoids with conformation-directing side chains by Hjelmgaard, Thomas, Faure, Sophie, De Santis, Emiliana, Staerk, Dan, Alexander, Bruce D., Edwards, Alison A., Taillefumier, Claude, Nielsen, John

“…The development of an improved methodology for iterative solid-phase synthesis of para- and meta-arylopeptoids (oligomeric N-substituted aminomethyl…”
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Effect of capping groups at the N- and C-termini on the conformational preference of α,β-peptoids by De Santis, Emiliana, Hjelmgaard, Thomas, Caumes, Cécile, Faure, Sophie, Alexander, Bruce D, Holder, Simon J, Siligardi, Giuliano, Taillefumier, Claude, Edwards, Alison A

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Cyclic α,β-peptoid octamers with differing side chain patterns: synthesis and conformational investigation by De Santis, Emiliana, Hjelmgaard, Thomas, Faure, Sophie, Roy, Olivier, Didierjean, Claude, Alexander, Bruce D., Siligardi, Giuliano, Hussain, Rohanah, Jávorfi, Tamás, Edwards, Alison A., Taillefumier, Claude

“…The solution-phase synthesis and cyclisation of three α,β-peptoid octamers with differing side chain patterns is reported. One of these, compound C , showed a…”
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Facet-Dependent Interactions of Islet Amyloid Polypeptide with Gold Nanoparticles: Implications for Fibril Formation and Peptide-Induced Lipid Membrane Disruption by Wang, Shih-Ting, Lin, Yiyang, Todorova, Nevena, Xu, Yingqi, Mazo, Manuel, Rana, Subinoy, Leonardo, Vincent, Amdursky, Nadav, Spicer, Christopher D, Alexander, Bruce D, Edwards, Alison A, Matthews, Steve J, Yarovsky, Irene, Stevens, Molly M

“…A comprehensive understanding of the mechanisms of interaction between proteins or peptides and nanomaterials is crucial for the development of…”
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Convenient Solution-Phase Synthesis and Conformational Studies of Novel Linear and Cyclic α,β-Alternating Peptoids by Hjelmgaard, Thomas, Faure, Sophie, Caumes, Cécile, De Santis, Emiliana, Edwards, Alison A, Taillefumier, Claude

“…The synthesis of a novel family of peptidomimetics composed of linear and cyclic α,β-alternating peptoids is described. Oligomers consisting of up to six…”
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Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon milling by Al-Hamidi, Hiba, Edwards, Alison A., Douroumis, Dionysis, Asare-Addo, Kofi, Nayebi, Alireza Mohajjel, Reyhani-Rad, Siamak, Mahmoudi, Javad, Nokhodchi, Ali

“…[Display omitted] ► Glucosamine HCl can be used as a potential excipient to improve dissolution rate. ► Glucosamine HCl increases the efficiency of…”
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Circular dichroism studies of low molecular weight hydrogelators: The use of SRCD and addressing practical issues by Sitsanidis, Efstratios D., Piras, Carmen C., Alexander, Bruce D., Siligardi, Giuliano, Jávorfi, Tamás, Hall, Andrew J., Edwards, Alison A.

“…Circular dichroism (CD) spectroscopy has been used extensively for the investigation of the conformation and configuration of chiral molecules, but its use for…”
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Glucosamine HCl as a new carrier for improved dissolution behaviour: Effect of grinding by Al-Hamidi, Hiba, Edwards, Alison A., Mohammad, Mohammad A., Nokhodchi, Ali

“…The co-grinding technique is one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs and it is superior to other…”
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C-3 branched δ-3,5-cis- and trans-THF sugar amino acids: synthesis of the first generation of branched homooligomers by Simone, Michela I., Edwards, Alison A., Tranter, George E., Fleet, George W. J.

“…This article describes the efficient synthesis of the first generation of branched sugar amino acid (SAA) oligomers in solution phase via two main routes: by…”
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Helix-Forming Carbohydrate Amino Acids by Claridge, Timothy D. W., Long, Daniel D., Baker, Christopher M., Odell, Barbara, Grant, Guy H., Edwards, Alison A., Tranter, George E., Fleet, George W. J., Smith, Martin D.

“…The solution-phase conformational properties of tetrameric and octameric chains of C-glycosyl α-d-lyxofuranose configured tetrahydrofuran amino acids (where…”
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Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids by Edwards, Alison A., Alexander, Bruce D., Fleet, George W. J., Tranter, George E.

“…Sugar amino acids and their oligomers, known as carbopeptoids, are commonly studied as foldamers. However, study of their conformational preference is often…”
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Classification of conformation for sugar amino acid systems using chiroptical spectroscopy by Edwards, Alison A., Fleet, George W. J., Tranter, George E.

“…A number of structurally related sugar amino acid systems have been examined by chiroptical methods to aid interpretation of their conformational preference…”
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(3 R ,4 R ,5 R )-5-(Acetamidomethyl)- N -benzyl-3,4-dihydroxytetrahydrofuran-3-carboxamide by Simone, Michela I., Edwards, Alison A., Cowley, Andrew R., Fleet, George W. J., Watkin, David J.

“…X-ray crystallographic analysis with Cu Kα radiation established the relative configurations of the stereogenic centers in the title compound, C15H20N2O5,…”
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Conformational studies of oligomeric oxetane-based dipeptide isosteres derived from L-rhamnose or D-xylose by Johnson, Stephen W., Jenkinson (née Barker), Sarah F., Pérez-Victoria, Ignacio, Edwards, Alison A., Claridge, Timothy D. W., Tranter, George E., Fleet, George W. J., Jones, John H.

“…Conformational investigations have been undertaken on oligomers (dimers, tetramers, hexamers) of five closely related oxetane‐based dipeptide isosteres. All…”
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Circular dichroism studies of carbopeptoid-cyclodextrins by Edwards, Alison A., Fleet, George W.J., Mayes, Ben A., Hunter, Stuart J., Tranter, George E.

“…A series of sugar amino acids, based on open chain sugars, have been oligomerised and cyclised. The resulting cyclic carbopeptoids have been examined for…”
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Stabilizing silica nanoparticles in hydrogels: impact on storage and polydispersity by Giovannini, Giorgia, Kunc, Filip, Piras, Carmen C., Stranik, Ondrej, Edwards, Alison A., Hall, Andrew J., Gubala, Vladimir

“…For successful nanomedicine, it is important that the unique, size-dependent physico-chemical properties of the nanomaterial remain predictably constant during…”
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Carbon-branched δ-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffolds by Simone, Michela I., Edwards, Alison A., Tranter, George E., Fleet, George W.J.

“…The synthesis of the first branched sugar amino acid (SAA) scaffolds [methyl (3 R,4 R,5 R)-5-azidomethyl-3,4-dihydroxy-tetrahydrofuran-3-carboxylate and methyl…”
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Pentafluorophenyl (3 R ,4 R ,5 S )-5-{[(3 R ,4 R ,5 S )-5-azidomethyl-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxamido]methyl}-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxylate by Simone, Michela I., Edwards, Alison A., Parker, Samuel G., Tranter, George E., Fleet, George W. J., Watkin, David J.

“…The title compound, C22H25F5N4O9, is a stable pentafluorophenyl ester intermediate in the synthesis of novel homo-oligomeric structures containing branched…”
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Penta-fluoro-phenyl (3R,4R,5S)-5-{[(3R,4R,5S)-5-azido-methyl-3,4-dimeth-oxy-2,3,4,5-tetra-hydro-furan-3-carboxamido]-meth-yl}-3,4-dimeth-oxy-2,3,4,5-tetra-hydro-furan-3-carboxyl-ate by Simone, Michela I, Edwards, Alison A, Parker, Samuel G, Tranter, George E, Fleet, George W J, Watkin, David J

“…The title compound, C(22)H(25)F(5)N(4)O(9), is a stable penta-fluoro-phenyl ester inter-mediate in the synthesis of novel homo-oligomeric structures containing…”
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