Search Results - "Edward Martucci, W."

Disruption of the crossover helix impairs dihydrofolate reductase activity in the bifunctional enzyme TS-DHFR from Cryptosporidium hominis by Vargo, Melissa A, Martucci, W Edward, Anderson, Karen S

“…In contrast with most species, including humans, which have monofunctional forms of the folate biosynthetic enzymes TS (thymidylate synthase) and DHFR…”
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Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen by Edward Martucci, W., Udier-Blagovic, Marina, Atreya, Chloe, Babatunde, Oladapo, Vargo, Melissa A., Jorgensen, William L., Anderson, Karen S.

“…The essential enzyme thymidylate synthase-dihydrofolate reductase (TS-DHFR) is a validated drug target for many pathogens, but has been elusive in…”
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Explaining an Unusually Fast Parasitic Enzyme: Folate Tail-Binding Residues Dictate Substrate Positioning and Catalysis in Cryptosporidium hominis Thymidylate Synthase by Martucci, W. Edward, Vargo, Melissa A, Anderson, Karen S

“…The essential enzyme TS-DHFR from Cryptosporidium hominis undergoes an unusually rapid rate of catalysis at the conserved TS domain, facilitated by two…”
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Nonconserved Residues Ala287 and Ser290 of the Cryptosporidium hominis Thymidylate Synthase Domain Facilitate Its Rapid Rate of Catalysis by Doan, Lanxuan T, Martucci, W. Edward, Vargo, Melissa A, Atreya, Chloé E, Anderson, Karen S

“…Cryptosporidium hominis TS-DHFR exhibits an unusually high rate of catalysis at the TS domain, at least 10-fold greater than those of other TS enzymes. Using…”
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Explaining an Unusually Fast Parasitic Enzyme: Folate Tail-Binding Residues Dictate Substrate Positioning and Catalysis in by Martucci, W. Edward, Vargo, Melissa A., Anderson, Karen S.

“…The essential enzyme TS-DHFR from Cryptosporidium hominis undergoes an unusually rapid rate of catalysis at the conserved TS domain, facilitated by two…”
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Multiple Oblique Illumination and High-Definition Microscopy for Breast Fine-Needle Aspirates by Puc, M M, Chrzanowski, Jr, F A, Tran, H, Geldziler, B, Martucci, M, Doolin, E J, Hewitt, C W

“…The ability of multiple oblique illumination (MOI) and high-definition microscopy (Edge R-400 3-D microscope) to improve resolution of cellular detail in the…”
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