Search Results - "Edward D. Karoly"

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome by Reitman, Zachary J, Jin, Genglin, Karoly, Edward D, Spasojevic, Ivan, Yang, Jian, Kinzler, Kenneth W, He, Yiping, Bigner, Darell D, Vogelstein, Bert, Yan, Hai

“…Point mutations of the NADP⁺-dependent isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) occur early in the pathogenesis of gliomas. When mutated, IDH1 and…”
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Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study by Niewczas, Monika A, Sirich, Tammy L, Mathew, Anna V, Skupien, Jan, Mohney, Robert P, Warram, James H, Smiles, Adam, Huang, Xiaoping, Walker, Walker, Byun, Jaeman, Karoly, Edward D, Kensicki, Elizabeth M, Berry, Gerard T, Bonventre, Joseph V, Pennathur, Subramaniam, Meyer, Timothy W, Krolewski, Andrzej S

“…Here we studied plasma metabolomic profiles as determinants of progression to end-stage renal disease (ESRD) in patients with type 2 diabetes (T2D). This…”
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SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans by Li, Veronica L., Xiao, Shuke, Schlosser, Pascal, Scherer, Nora, Wiggenhorn, Amanda L., Spaas, Jan, Tung, Alan Sheng-Hwa, Karoly, Edward D., Köttgen, Anna, Long, Jonathan Z.

“…N-lactoyl-phenylalanine (Lac-Phe) is a lactate-derived metabolite that suppresses food intake and body weight. Little is known about the mechanisms that…”
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Effect of acute ozone exposure on the lung metabolomes of obese and lean mice by Mathews, Joel Andrew, Kasahara, David Itiro, Cho, Youngji, Bell, Lauren Nicole, Gunst, Philip Ross, Karoly, Edward D, Shore, Stephanie Ann

“…Pulmonary responses to the air pollutant, ozone, are increased in obesity. Both obesity and ozone cause changes in systemic metabolism. Consequently, we…”
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Oncogene-induced senescence results in marked metabolic and bioenergetic alterations by Quijano, Celia, Cao, Liu, Fergusson, Maria M., Romero, Hector, Liu, Jie, Gutkind, Sarah, Rovira, Ilsa I., Mohney, Robert P., Karoly, Edward D, Finkel, Toren

“…Oncogene-induced senescence (OIS) is characterized by permanent growth arrest and the acquisition of a secretory, pro-inflammatory state. Increasingly, OIS is…”
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Ozone-induced changes in the serum metabolome: Role of the microbiome by Cho, Youngji, Osgood, Ross S, Bell, Lauren N, Karoly, Edward D, Shore, Stephanie A

“…Ozone is an asthma trigger. In mice, the gut microbiome contributes to ozone-induced airway hyperresponsiveness, a defining feature of asthma, but the…”
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Large-scaled metabolic profiling of human dermal fibroblasts derived from pseudoxanthoma elasticum patients and healthy controls by Kuzaj, Patricia, Kuhn, Joachim, Michalek, Ryan D, Karoly, Edward D, Faust, Isabel, Dabisch-Ruthe, Mareike, Knabbe, Cornelius, Hendig, Doris

“…Mutations in the ABC transporter ABCC6 were recently identified as cause of Pseudoxanthoma elasticum (PXE), a rare genetic disorder characterized by…”
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Metabolome Genome-Wide Association Study Identifies 74 Novel Genomic Regions Influencing Plasma Metabolites Levels by Hysi, Pirro G, Mangino, Massimo, Christofidou, Paraskevi, Falchi, Mario, Karoly, Edward D, Nihr Bioresource Investigators, Mohney, Robert P, Valdes, Ana M, Spector, Tim D, Menni, Cristina

“…Metabolites are small products of metabolism that provide a snapshot of the wellbeing of an organism and the mechanisms that control key physiological…”
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Prospective serum metabolomic profile of prostate cancer by size and extent of primary tumor by Huang, Jiaqi, Mondul, Alison M, Weinstein, Stephanie J, Karoly, Edward D, Sampson, Joshua N, Albanes, Demetrius

“…Two recent investigations found serum lipid and energy metabolites related to aggressive prostate cancer up to 20 years prior to diagnosis. To elucidate…”
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Metabolomics of dates (Phoenix dactylifera) reveals a highly dynamic ripening process accounting for major variation in fruit composition by Diboun, Ilhame, Mathew, Sweety, Al-Rayyashi, Maryam, Elrayess, Mohamed, Torres, Maria, Halama, Anna, Méret, Michaël, Mohney, Robert P, Karoly, Edward D, Malek, Joel, Suhre, Karsten

“…Dates are tropical fruits with appreciable nutritional value. Previous attempts at global metabolic characterization of the date metabolome were constrained by…”
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Inactivation of metabolic genes causes short- and long-range dys-regulation in Escherichia coli metabolic network by Barupal, Dinesh Kumar, Lee, Sang Jun, Karoly, Edward D, Adhya, Sankar

“…The metabolic network in E. coli can be severely affected by the inactivation of metabolic genes that are required to catabolize a nutrient (D-galactose). We…”
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Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia by Montrose, David C, Zhou, Xi Kathy, Kopelovich, Levy, Yantiss, Rhonda K, Karoly, Edward D, Subbaramaiah, Kotha, Dannenberg, Andrew J

“…Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Although noninvasive stool-based screening tests are used for the…”
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Metabolome Changes during In Vivo Red Cell Aging Reveal Disruption of Key Metabolic Pathways by Jamshidi, Neema, Xu, Xiuling, von Löhneysen, Katharina, Soldau, Katrin, Mohney, Rob P., Karoly, Edward D., Scott, Mike, Friedman, Jeffrey S.

“…Understanding the mechanisms for cellular aging is a fundamental question in biology. Normal red blood cells (RBCs) survive for approximately 100 days, and…”
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PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation by Patsoukis, Nikolaos, Bardhan, Kankana, Chatterjee, Pranam, Sari, Duygu, Liu, Bianling, Bell, Lauren N., Karoly, Edward D., Freeman, Gordon J., Petkova, Victoria, Seth, Pankaj, Li, Lequn, Boussiotis, Vassiliki A.

“…During activation, T cells undergo metabolic reprogramming, which imprints distinct functional fates. We determined that on PD-1 ligation, activated T cells…”
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HuR is a post-transcriptional regulator of core metabolic enzymes in pancreatic cancer by Burkhart, Richard A, Pineda, Danielle M, Chand, Saswati N, Romeo, Carmella, Londin, Eric R, Karoly, Edward D, Cozzitorto, Joseph A, Rigoutsos, Isidore, Yeo, Charles J, Brody, Jonathan R, Winter, Jordan M

“…Cancer cell metabolism differs from normal cells, yet the regulatory mechanisms responsible for these differences are incompletely understood, particularly in…”
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Comparison of Gene Expression Profiles Induced By Coarse, Fine, and Ultrafine Particulate Matter by Huang, Yuh-Chin T., Karoly, Edward D., Dailey, Lisa A., Schmitt, Michael T., Silbajoris, Robert, Graff, Donald W., Devlin, Robert B.

“…Coarse, fine, and ultrafine particulate matter (PM) fractions possess different physical properties and chemical compositions and may produce different adverse…”
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Metabolomic analysis of prostate cancer risk in a prospective cohort: The alpha‐tocopherol, beta‐carotene cancer prevention (ATBC) study by Mondul, Alison M., Moore, Steven C., Weinstein, Stephanie J., Karoly, Edward D., Sampson, Joshua N., Albanes, Demetrius

“…Despite decades of concerted epidemiological research, relatively little is known about the etiology of prostate cancer. As genome‐wide association studies…”
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Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function by Sukumar, Madhusudhanan, Liu, Jie, Ji, Yun, Subramanian, Murugan, Crompton, Joseph G, Yu, Zhiya, Roychoudhuri, Rahul, Palmer, Douglas C, Muranski, Pawel, Karoly, Edward D, Mohney, Robert P, Klebanoff, Christopher A, Lal, Ashish, Finkel, Toren, Restifo, Nicholas P, Gattinoni, Luca

“…Naive CD8+ T cells rely upon oxidation of fatty acids as a primary source of energy. After antigen encounter, T cells shift to a glycolytic metabolism to…”
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The Role of Particulate Matter-Associated Zinc in Cardiac Injury in Rats by Kodavanti, Urmila P., Schladweiler, Mette C., Gilmour, Peter S., J. Grace Wallenborn, Bhaskar S. Mandavilli, Ledbetter, Allen D., Christiani, David C., Runge, Marschall S., Edward D. Karoly, Costa, Daniel L., Peddada, Shyamal, Richard Jaskot, Richards, Judy H., Thomas, Ronald, Madamanchi, Nageswara R., Nyska, Abraham

“…Background: Exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity; however, causative components are unknown. Zinc is…”
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Up-Regulation of Tissue Factor in Human Pulmonary Artery Endothelial Cells after Ultrafine Particle Exposure by Edward D. Karoly, Li, Zhuowei, Dailey, Lisa A., Xhevahire Hyseni, Huang, Yuh-Chin T.

“…Background: Epidemiology studies have linked exposure to pollutant particles to increased cardiovascular mortality and morbidity, but the mechanisms remain…”
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