Search Results - "Edward Cox"

The Emergency Use Authorization of Peramivir for Treatment of 2009 H1N1 Influenza by Birnkrant, Debra, Cox, Edward

“…On October 23 the FDA issued an Emergency Use Authorization for peramivir for the treatment of suspected or confirmed cases of 2009 H1N1 influenza. Drs. Debra…”
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Persistent cell motion in the absence of external signals: a search strategy for eukaryotic cells by Li, Liang, Nørrelykke, Simon F, Cox, Edward C

“…Eukaryotic cells are large enough to detect signals and then orient to them by differentiating the signal strength across the length and breadth of the cell…”
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Site-specific chromosomal integration of large synthetic constructs by Kuhlman, Thomas E, Cox, Edward C

“…We have developed an effective, easy-to-use two-step system for the site-directed insertion of large genetic constructs into arbitrary positions in the…”
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An Analysis of Antibacterial Drug Development Trends in the United States, 1980–2019 by Dheman, Nidhi, Mahoney, Nicole, Cox, Edward M, Farley, John J, Amini, Thushi, Lanthier, Michael L

“…Abstract We present a longitudinal analysis of investigational new drug applications (INDs) for new, systemic antibacterial drugs under active development…”
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Physical nature of bacterial cytoplasm by Golding, Ido, Cox, Edward C

“…We track the motion of individual fluorescently labeled mRNA molecules inside live E. coli cells. We find that the motion is subdiffusive, with an exponent…”
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Real-Time Kinetics of Gene Activity in Individual Bacteria by Golding, Ido, Paulsson, Johan, Zawilski, Scott M., Cox, Edward C.

“…Protein levels have been shown to vary substantially between individual cells in clonal populations. In prokaryotes, the contribution to such fluctuations from…”
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Gene location and DNA density determine transcription factor distributions in Escherichia coli by Kuhlman, Thomas E, Cox, Edward C

“…The diffusion coefficient of the transcription factor LacI within living Escherichia coli has been measured directly by in vivo tracking to be D =0.4  μ m 2…”
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'Dicty dynamics': Dictyostelium motility as persistent random motion by Li, Liang, Cox, Edward C, Flyvbjerg, Henrik

“…We model the motility of Dictyostelium cells in a systematic data-driven manner. We deduce a minimal dynamical model that reproduces the statistical features…”
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Using deep sequencing to characterize the biophysical mechanism of a transcriptional regulatory sequence by Kinney, Justin B, Murugan, Anand, Callan, Curtis G. Jr, Cox, Edward C

“…Cells use protein-DNA and protein-protein interactions to regulate transcription. A biophysical understanding of this process has, however, been limited by the…”
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Continuous Particle Separation through Deterministic Lateral Displacement by Huang, Lotien Richard, Cox, Edward C., Austin, Robert H., Sturm, James C.

“…We report on a microfluidic particle-separation device that makes use of the asymmetric bifurcation of laminar flow around obstacles. A particle chooses its…”
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Combating Emerging Threats — Accelerating the Availability of Medical Therapies by Borio, Luciana, Cox, Edward, Lurie, Nicole

“…A new paradigm for accelerating evaluation of investigational therapies during public health emergencies caused by emerging infectious diseases could permit…”
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Single molecule measurements of repressor protein 1D diffusion on DNA by Wang, Y M, Austin, Robert H, Cox, Edward C

“…We used single-molecule imaging techniques and measured the one-dimensional diffusion of LacI repressor proteins along elongated DNA to address the…”
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Devices for remote continuous monitoring of people with Parkinson's disease: a systematic review and cost-effectiveness analysis by Cox, Edward, Wade, Ros, Hodgson, Robert, Fulbright, Helen, Phung, Thai Han, Meader, Nicholas, Walker, Simon, Rothery, Claire, Simmonds, Mark

“…Parkinson's disease is a brain condition causing a progressive loss of co ordination and movement problems. Around 145,500 people have Parkinson's disease in…”
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An excitable cortex and memory model successfully predicts new pseudopod dynamics by Cooper, Robert M, Wingreen, Ned S, Cox, Edward C

“…Motile eukaryotic cells migrate with directional persistence by alternating left and right turns, even in the absence of external cues. For example,…”
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The cost-effectiveness of a proportionate parenting programme for primary caregivers and their child: an economic evaluation using evidence from the E-SEE Trial by Cox, Edward, Walker, Simon, Blower, Sarah, Sampaio, Filipa, Bywater, Tracey, Richardson, Gerry

“…Behavioural and mental disorders have become a public health crisis; averting mental ill-health in early years can achieve significant longer-term health…”
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RNA Dynamics in Live Escherichia coli Cells by Golding, Ido, Cox, Edward C., Austin, Robert H.

“…We describe a method for tracking RNA molecules in Escherichia coli that is sensitive to single copies of mRNA, and, using the method, we find that individual…”
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A review of the nature and source of nutrient impairment in small streams: a desk based characterisation for targeted mitigation measures by Hogan, Sinéad C., O’Sullivan, John J., Bruen, Michael, Jarvie, Helen P., Cox, Edward J., Bowes, Mike J., Kelly-Quinn, Mary

“…Recent research has highlighted the need to refocus research and management on small streams to address wider catchment water quality and biodiversity…”
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A multi-scale analysis and classification of the hydrogeomorphological characteristics of Irish headwater streams by Cox, Edward J., Gurnell, Angela M., Bowes, Michael J., Bruen, Michael, Hogan, Sinéad C., O’Sullivan, John J., Kelly-Quinn, Mary

“…We present a spatially hierarchical, hydrogeomorphological stream classification, based on data collected in Ireland and reflecting our hypothesis that local…”
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A randomized controlled trial of a proportionate universal parenting program delivery model (E-SEE Steps) to enhance child social-emotional wellbeing by Bywater, Tracey, Berry, Vashti, Blower, Sarah, Bursnall, Matthew, Cox, Edward, Mason-Jones, Amanda, McGilloway, Sinead, McKendrick, Kirsty, Mitchell, Siobhan, Pickett, Kate, Richardson, Gerry, Solaiman, Kiera, Teare, M Dawn, Walker, Simon, Whittaker, Karen

“…Evidence for parenting programs to improve wellbeing in children under three is inconclusive. We investigated the fidelity, impact, and cost-effectiveness of…”
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The Dynamics of Genomic-Length DNA Molecules in 100-nm Channels by Tegenfeldt, Jonas O., Prinz, Christelle, Cao, Han, Chou, Steven, Reisner, Walter W., Riehn, Robert, Wang, Yan Mei, Cox, Edward C., Sturm, James C., Silberzan, Pascal, Austin, Robert H.

“…We show that genomic-length DNA molecules imaged in nanochannels have an extension along the channel that scales linearly with the contour length of the…”
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