Search Results - "Edward A. Kuhn"

Antibiotic Treatment Prior to Injury Improves Post-Traumatic Osteoarthritis Outcomes in Mice by Mendez, Melanie E, Murugesh, Deepa K, Sebastian, Aimy, Hum, Nicholas R, McCloy, Summer A, Kuhn, Edward A, Christiansen, Blaine A, Loots, Gabriela G

“…Osteoarthritis (OA) is a painful and debilitating disease characterized by the chronic and progressive degradation of articular cartilage. Post-traumatic OA…”
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Development of a CNS-permeable reactivator for nerve agent exposure: an iterative, multi-disciplinary approach by Bennion, Brian J., Malfatti, Michael A., Be, Nicholas A., Enright, Heather A., Hok, Saphon, Cadieux, C. Linn, Carpenter, Timothy S., Lao, Victoria, Kuhn, Edward A., McNerney, M. Windy, Lightstone, Felice C., Nguyen, Tuan H., Valdez, Carlos A.

“…Nerve agents have experienced a resurgence in recent times with their use against civilian targets during the attacks in Syria (2012), the poisoning of Sergei…”
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Maternal exposure to an environmentally relevant dose of triclocarban results in perinatal exposure and potential alterations in offspring development in the mouse model by Enright, Heather A, Falso, Miranda J S, Malfatti, Michael A, Lao, Victoria, Kuhn, Edward A, Hum, Nicholas, Shi, Yilan, Sales, Ana Paula, Haack, Kurt W, Kulp, Kristen S, Buchholz, Bruce A, Loots, Gabriela G, Bench, Graham, Turteltaub, Kenneth W

“…Triclocarban (TCC) is among the top 10 most commonly detected wastewater contaminants in both concentration and frequency. Its presence in water, as well as…”
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Cell-free Co-expression of Functional Membrane Proteins and Apolipoprotein, Forming Soluble Nanolipoprotein Particles by Cappuccio, Jenny A., Blanchette, Craig D., Sulchek, Todd A., Arroyo, Erin S., Kralj, Joel M., Hinz, Angela K., Kuhn, Edward A., Chromy, Brett A., Segelke, Brent W., Rothschild, Kenneth J., Fletcher, Julia E., Katzen, Federico, Peterson, Todd C., Kudlicki, Wieslaw A., Bench, Graham, Hoeprich, Paul D., Coleman, Matthew A.

“…Here we demonstrate rapid production of solubilized and functional membrane protein by simultaneous cell-free expression of an apolipoprotein and a membrane…”
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Different Apolipoproteins Impact Nanolipoprotein Particle Formation by Chromy, Brett A, Arroyo, Erin, Blanchette, Craig D, Bench, Graham, Benner, Henry, Cappuccio, Jenny A, Coleman, Matthew A, Henderson, Paul T, Hinz, Angie K, Kuhn, Edward A, Pesavento, Joseph B, Segelke, Brent W, Sulchek, Todd A, Tarasow, Ted, Walsworth, Vicki L, Hoeprich, Paul D

“…Spontaneous interaction of purified apolipoproteins and phospholipids results in formation of lipoprotein particles with nanometer-sized dimensions; we refer…”
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Quantifying size distributions of nanolipoprotein particles with single-particle analysis and molecular dynamic simulations by Blanchette, Craig D., Law, Richard, Benner, W. Henry, Pesavento, Joseph B., Cappuccio, Jenny A., Walsworth, Vicki, Kuhn, Edward A., Corzett, Michele, Chromy, Brett A., Segelke, Brent W., Coleman, Matthew A., Bench, Graham, Hoeprich, Paul D., Sulchek, Todd A.

“…Self-assembly of purified apolipoproteins and phospholipids results in the formation of nanometer-sized lipoprotein complexes, referred to as nanolipoprotein…”
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Isolation, characterization, and stability of discretely-sized nanolipoprotein particles assembled with apolipophorin-III by Fischer, Nicholas O, Blanchette, Craig D, Segelke, Brent W, Corzett, Michele, Chromy, Brett A, Kuhn, Edward A, Bench, Graham, Hoeprich, Paul D

“…Nanolipoprotein particles (NLPs) are discoidal, nanometer-sized particles comprised of self-assembled phospholipid membranes and apolipoproteins. NLPs…”
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Hydrogen Production by a Hyperthermophilic Membrane-Bound Hydrogenase in Water-Soluble Nanolipoprotein Particles by Baker, Sarah E, Hopkins, Robert C, Blanchette, Craig D, Walsworth, Vicki L, Sumbad, Rhoda, Fischer, Nicholas O, Kuhn, Edward A, Coleman, Matt, Chromy, Brett A, Létant, Sonia E, Hoeprich, Paul D, Adams, Michael W. W, Henderson, Paul T

“…Hydrogenases constitute a promising class of enzymes for ex vivo hydrogen production. Implementation of such applications is currently hindered by oxygen…”
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Cell-free expression for nanolipoprotein particles: building a high-throughput membrane protein solubility platform by Cappuccio, Jenny A, Hinz, Angela K, Kuhn, Edward A, Fletcher, Julia E, Arroyo, Erin S, Henderson, Paul T, Blanchette, Craig D, Walsworth, Vickie L, Corzett, Michele H, Law, Richard J, Pesavento, Joseph B, Segelke, Brent W, Sulchek, Todd A, Chromy, Brett A, Katzen, Federico, Peterson, Todd, Bench, Graham, Kudlicki, Wieslaw, Hoeprich, Jr, Paul D, Coleman, Matthew A

“…Membrane-associated proteins and protein complexes account for approximately a third or more of the proteins in the cell (1, 2). These complexes mediate…”
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Evaluation of in vitro neuronal platforms as surrogates for in vivo whole brain systems by Belle, Anna M., Enright, Heather A., Sales, Ana Paula, Kulp, Kristen, Osburn, Joanne, Kuhn, Edward A., Fischer, Nicholas O., Wheeler, Elizabeth K.

“…Quantitatively benchmarking similarities and differences between the in vivo central nervous system and in vitro neuronal cultures can qualify discrepancies in…”
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Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice by Malfatti, Michael A., Kuhn, Edward A., Murugesh, Deepa K., Mendez, Melanie E., Hum, Nicholas, Thissen, James B., Jaing, Crystal J., Loots, Gabriela G.

“…The gut microbiota is a vast and diverse microbial community that has co-evolved with its host to perform a variety of essential functions involved in the…”
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Characterization and purification of polydisperse reconstituted lipoproteins and nanolipoprotein particles by Blanchette, Craig D, Segelke, Brent W, Fischer, Nicholas, Corzett, Michele H, Kuhn, Edward A, Cappuccio, Jenny A, Benner, William Henry, Coleman, Matthew A, Chromy, Brett A, Bench, Graham, Hoeprich, Paul D, Sulchek, Todd A

“…Heterogeneity is a fact that plagues the characterization and application of many self-assembled biological constructs. The importance of obtaining particle…”
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Naphthalene genotoxicity: DNA adducts in primate and mouse airway explants by Carratt, Sarah A., Hartog, Matthew, Buchholz, Bruce A., Kuhn, Edward A., Collette, Nicole M., Ding, Xinxin, Van Winkle, Laura S.

“…•Naphthalene DNA adducts were detected in primate and mouse airways.•Female mouse (4.7-fold) and primate (2.1-fold) airway adducts exceeded male levels.•Few…”
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Determining the Pharmacokinetics and Long-Term Biodistribution of SiO2 Nanoparticles In Vivo Using Accelerator Mass Spectrometry by Malfatti, Michael A, Palko, Heather A, Kuhn, Edward A, Turteltaub, Kenneth W

“…Biodistribution is an important factor in better understanding silica dioxide nanoparticle (SiNP) safety. Currently, comprehensive studies on biodistribution…”
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The biodistribution and pharmacokinetics of the oxime acetylcholinesterase reactivator RS194B in guinea pigs by Malfatti, Michael A., Enright, Heather A., Be, Nicholas A., Kuhn, Edward A., Hok, Saphon, McNerney, M. Windy, Lao, Victoria, Nguyen, Tuan H., Lightstone, Felice C., Carpenter, Timothy S., Bennion, Brian J., Valdez, Carlos A.

“…Organophosphorus-based (OP) nerve agents represent some of the most toxic substances known to mankind. The current standard of care for exposure has changed…”
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Naphthalene DNA adduct formation and tolerance in the lung by Buchholz, Bruce A., Carratt, Sarah A., Kuhn, Edward A., Collette, Nicole M., Ding, Xinxin, Van Winkle, Laura S.

“…Naphthalene (NA) is a respiratory toxicant and possible human carcinogen. NA is a ubiquitous combustion product and significant component of jet fuel. The…”
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Disposition of the Dietary Mutagen 2‑Amino-3,8-dimethylimidazo[4,5‑f]quinoxaline in Healthy and Pancreatic Cancer Compromised Humans by Malfatti, Michael A, Kuhn, Edward A, Turteltaub, Kenneth W, Vickers, Selwyn M, Jensen, Eric H, Strayer, Lori, Anderson, Kristin E

“…Pancreatic cancer is the fourth leading cause of cancer death in the U.S. Once diagnosed, prognosis is poor with a 5-year survival rate of less than 5%…”
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Remote sensing and geographic information systems: charting Sin Nombre virus infections in deer mice by Boone, J D, McGwire, K C, Otteson, E W, DeBaca, R S, Kuhn, E A, Villard, P, Brussard, P F, St Jeor, S C

“…We tested environmental data from remote sensing and geographic information system maps as indicators of Sin Nombre virus (SNV) infections in deer mouse…”
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Immobilization of His-Tagged Proteins on Nickel-Chelating Nanolipoprotein Particles by Fischer, Nicholas O, Blanchette, Craig D, Chromy, Brett A, Kuhn, Edward A, Segelke, Brent W, Corzett, Michele, Bench, Graham, Mason, Peter W, Hoeprich, Paul D

“…Nanolipoprotein particles (NLPs) are nanometer-sized, discoidal particles that self-assemble from purified apolipoprotein and phospholipid. Their size and…”
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Atomic force microscopy differentiates discrete size distributions between membrane protein containing and empty nanolipoprotein particles by Blanchette, Craig D., Cappuccio, Jenny A., Kuhn, Edward A., Segelke, Brent W., Benner, W. Henry, Chromy, Brett A., Coleman, Matthew A., Bench, Graham, Hoeprich, Paul D., Sulchek, Todd A.

“…To better understand the incorporation of membrane proteins into discoidal nanolipoprotein particles (NLPs) we have used atomic force microscopy (AFM) to image…”
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