Search Results - "Edward, Jakubowski"

Immunomagnetic Separation and Quantification of Butyrylcholinesterase Nerve Agent Adducts in Human Serum by Sporty, Jennifer L. S, Lemire, Sharon W, Jakubowski, Edward M, Renner, Julie A, Evans, Ronald A, Williams, Robert F, Schmidt, Jurgen G, Schans, Marcel J. van der, Noort, Daan, Johnson, Rudolph C

“…A novel method for extracting butyrylcholinesterase (BuChE) from serum as a means of identifying and measuring nerve agent adducts to human BuChE is presented…”
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Prophylaxis with human serum butyrylcholinesterase protects Göttingen minipigs exposed to a lethal high-dose of sarin vapor by Saxena, Ashima, Hastings, Nicholas B., Sun, Wei, Dabisch, Paul A., Hulet, Stanley W., Jakubowski, Edward M., Mioduszewski, Robert J., Doctor, Bhupendra P.

“…Serum-derived human butyrylcholinesterase (Hu BChE) is a stoichiometric bioscavenger that is being developed as a potential prophylactic nerve agent…”
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Pretreatment with human serum butyrylcholinesterase alone prevents cardiac abnormalities, seizures, and death in Göttingen minipigs exposed to sarin vapor by Saxena, Ashima, Sun, Wei, Dabisch, Paul A., Hulet, Stanley W., Hastings, Nicholas B., Jakubowski, Edward M., Mioduszewski, Robert J., Doctor, Bhupendra P.

“…Pretreatment with 7.5mg/kg of Hu BChE alone protected Göttingen minipigs from GB vapor-induced cardiac abnormalities, seizures, and death by sequestering GB in…”
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High-Throughput Immunomagnetic Scavenging Technique for Quantitative Analysis of Live VX Nerve Agent in Water, Hamburger, and Soil Matrixes by Knaack, Jennifer S, Zhou, Yingtao, Abney, Carter W, Prezioso, Samantha M, Magnuson, Matthew, Evans, Ronald, Jakubowski, Edward M, Hardy, Katelyn, Johnson, Rudolph C

“…We have developed a novel immunomagnetic scavenging technique for extracting cholinesterase inhibitors from aqueous matrixes using biological targeting and…”
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Efficacy of human serum butyrylcholinesterase against sarin vapor by Saxena, Ashima, Sun, Wei, Dabisch, Paul A., Hulet, Stanley W., Hastings, Nicholas B., Jakubowski, Edward M., Mioduszewski, Robert J., Doctor, Bhupendra P.

“…Human serum butyrylcholinesterase (Hu BChE) is currently under advanced development as a pretreatment drug for organophosphate (OP) poisoning in humans. It was…”
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Determination of VX-G Analogue in Red Blood Cells via Gas Chromatography-Tandem Mass Spectrometry Following an Accidental Exposure to VX by McGuire, Jeffrey M., Taylor, James T., Byers, Christopher E., Jakubowski, Edward M., Thomson, Sandra A.

“…A sensitive method for determining exposure to the chemical warfare agent VX is described in which the biomarker ethyl methylphosphonofluoridate (VX-G) is…”
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Quantification of Nerve Agent VX-Butyrylcholinesterase Adduct Biomarker from an Accidental Exposure by Solano, Maria I., Thomas, Jerry D., Taylor, James T., McGuire, Jeffrey M., Jakubowski, Edward M., Thomson, Sandra A., Maggio, Vincent L., Holland, Kerry E., Smith, J. Richard, Capacio, Benedict, Woolfitt, Adrian R., Ashley, David L., Barr, John R.

“…The lack of data in the open literature on human exposure to the nerve agent O-ethyl-S-(2-diisopropylaminoethyl) methylphosphonothioate (VX) gives a special…”
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Validation and Application of a GC-MS Method for Determining Soman Concentration in Rat Plasma Following Low-Level Vapor Exposure by Renner, Julie A., Dabisch, Paul A., Evans, Ronald A., McGuire, Jeffrey M., Totura, Allison L., Jakubowski, Edward M., Thomson, Sandra A.

“…A method for determining the chemical warfare agent soman (GD) in rat plasma has been validated and applied to low-level inhalation exposure studies currently…”
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Effects of Low-level Inhalation Exposure to Cyclosarin on Learned Behaviors in Sprague-Dawley Rats by Genovese, Raymond F., Benton, Bernard J., Shippee, Sara J., Jakubowski, Edward M., Bonnell, Jessica C.

“…Behavioral and biochemical effects of low-level whole-body inhalation exposure to the chemical warfare nerve agent cyclosarin (GF) were evaluated…”
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Kinetics of Sarin (GB) Following a Single Sublethal Inhalation Exposure in the Guinea Pig by Whalley, Christopher E., McGuire, Jeffrey M., Miller, Dennis B., Jakubowski, Edward M., Mioduszewski, Robert J., Thomson, Sandra A., Lumley, Lucille A., McDonough, John H., Shih, Tsung-Ming A.

“…To improve toxicity estimates from sublethal exposures to chemical warfare nerve agents (CWNA), it is necessary to generate mathematical models of the…”
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A Rapid and Sensitive Technique for Assessing Exposure VX via GC-MS-MS Analysis by McGuire, Jeffrey M., Byers, Christopher E., Hulet, Stanley W., Jakubowski, Edward M., Thomson, Sandra A.

“…A rapid and sensitive method for the determination of the chemical warfare agent VX in plasma taken from Göttingen minipigs® has been developed using…”
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Tolerance to the miotic effect of sarin vapor in rats after multiple low-level exposures by Dabisch, Paul A, Burnett, David C, Miller, Dennis B, Jakubowski, Edward M, Muse, William T, Forster, Jeffry S, Scotto, Jacqueline A, Jarvis, Jill R, Davis, Emily A, Hulet, Stanley W, Reutter, Sharon A, Mioduszewski, Robert J, Thomson, Sandra A

“…Inhibition of acetylcholinesterase (AChE) by the organophosphorous compound sarin (GB) results in the accumulation of acetylcholine and excessive cholinergic…”
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Detection and measurement of sulfur mustard offgassing from the weanling pig following exposure to saturated sulfur mustard vapor by Logan, Thomas P., Graham, John S., Martin, Jamie L., Zallnick, John E., Jakubowski, Edward M., Braue, Ernest H.

“…Animal models are employed to investigate mechanisms of injury and to evaluate protective measures against sulfur mustard (HD) exposure. The ability to detect…”
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VERIFICATION OF LEWISITE EXPOSURE BY THE ANALYSIS OF 2-CHLOROVINYL ARSONOUS ACID IN URINE by Logan, Thomas, Richard, Smith, Edward, Jakubowski, Ronald, Nielson

“…Verification of lewisite (L) exposure aids in the proper medical treatment of personnel who have come into contact with this vesicant. The purpose of this…”
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Determination ofVX-G Analogue in Red Blood Cells via Gas Chromatography-Tandem Mass Spectrometry Following an Accidental Exposure to VX: Analysis of Biological Samples for Chemical Warfare Agents by MCGUIRE, Jeffrey M, TAYLOR, James T, BYERS, Christopher E, JAKUBOWSKI, Edward M, THOMSON, Sandra A

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A Rapid and Sensitive Technique for Assessing Exposure to VX via GC-MS-MS Analysis: Analysis of Biological Samples for Chemical Warfare Agents by MCCUIRE, Jeffrey M, BYERS, Christopher E, HULET, Stanley W, JAKUBOWSKI, Edward M, THOMSON, Sandra A

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Effects of Low-Level Inhalation Exposure to Cyclosarin on Learned Behaviors in Sprague-Dawley Rats by Genovese, Raymond F, Benton, Bernard J, Shippee, Sara J, Jakubowski, Edward M, Bonnell, Jessica C

“…The effects of low-level inhalation exposure to cyclosarin on learned behaviors in Sprague-Dawley rats are investigated. Sprague-Dawley rats are first trained…”
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Validation and Application of a GC-MS Method for Determining Soman Concentration in Rat Plasma Following Low-Level Vapor Exposure: Analysis of Biological Samples for Chemical Warfare Agents by RENNER, Julie A, DABISCH, Paul A, EVANS, Ronald A, MCGUIRE, Jeffrey M, TOTURA, Allison L, JAKUBOWSKI, Edward M, THOMSON, Sandra A

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Kinetics of Sarin (GB) Following a Single Sublethal Inhalation Exposure in the Guinea Pig by Whalley, Christopher E, McGuire, Jeffrey M, Jakubowski, Edward M, Mioduszewski, Robert J, Thomas, Sandra A, Lumley, Lucille A, McDonough, John H

“…Kinetics of sarin (GB) following a single sublethal inhalation exposure in the Guinea pig was presented. Specific objective was to compare uptake and clearance…”
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Quantification of Nerve Agent VX-Butyrylcholinesterase Adduct Biomarker from an Accidental Exposure: Analysis of Biological Samples for Chemical Warfare Agents by SOLANO, Maria I, THOMAS, Jerry D, WOOLFITT, Adrian R, ASHLEY, David L, BARR, John R, TAYLOR, James T, MCGUIRE, Jeffrey M, JAKUBOWSKI, Edward M, THOMSON, Sandra A, MAGGIO, Vincent L, HOLLAND, Kerry E, SMITH, J. Richard, CAPACIO, Benedict

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