Standardization of procalcitonin, C-reactive protein and lactate levels in pigs submitted to laparotomy

Objective: To determine the procalcitonin, C-reactive protein and lactate levels in pigs anesthetized and submitted to laparotomy during 5 hours. Methods: A total of 05 landrace pigs with 3 months of age and weighing 20 kg were used. After a midline xiphopubic laparotomy, the procalcitonin, C-reacti...

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Bibliographic Details
Published in:	Bioscience journal Vol. 27; no. 3
Main Authors:	Rogerio Magno do Vale Barroso, Javier González-Gallego, Ednaldo Carvalho GUIMAR, Edgar Gatti, Guilherme Emerick, Andréia Luiza Araújo, Gynna Carla de O. Pinheiro
Format:	Journal Article
Language:	English
Published:	Universidade Federal de Uberlândia 01-05-2011
Subjects:	inflammation mediators pigs reference standards
Online Access:	Get full text
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Summary:	Objective: To determine the procalcitonin, C-reactive protein and lactate levels in pigs anesthetized and submitted to laparotomy during 5 hours. Methods: A total of 05 landrace pigs with 3 months of age and weighing 20 kg were used. After a midline xiphopubic laparotomy, the procalcitonin, C-reactive protein and lactate levels were measured at intervals of 60 minutes for 5 hours with samples taken from the jugular vein. Results: The procalcitonin value remained below 0.05 Âµg. The CRP values were between 6.7 and 8.3 and lactate levels remained between 2.9 and 3.7 for the confidence interval of 95%. Conclusion: In pigs submitted to laparotomy for 5 hours, the procalcitonin levels did not exceed 0.05 ng / mL. The C-reactive protein and lactate levels were between 6.7 and 8.3 mg / L and 2.9 and 3.7 mg / d, respectively. These data allowed reducing the number of animals.
ISSN:	1981-3163