Search Results - "Edmond, Valérie"

Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN by Benlabiod, Camélia, Cacemiro, Maira da Costa, Nédélec, Audrey, Edmond, Valérie, Muller, Delphine, Rameau, Philippe, Touchard, Laure, Gonin, Patrick, Constantinescu, Stefan N., Raslova, Hana, Villeval, Jean-Luc, Vainchenker, William, Plo, Isabelle, Marty, Caroline

“…Somatic mutations in the calreticulin ( CALR ) gene are associated with approximately 30% of essential thrombocythemia (ET) and primary myelofibrosis (PMF)…”
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Impaired fibrinolysis in JAK2V617F-related myeloproliferative neoplasms by Bourrienne, Marie-Charlotte, Loyau, Stéphane, Faille, Dorothée, Gay, Juliette, Akhenak, Séléna, Farkh, Carine, Ollivier, Véronique, Solonomenjanahary, Mialitiana, Dupont, Sébastien, Choqueux, Christine, Villeval, Jean-Luc, Plo, Isabelle, Edmond, Valérie, Ho-Tin-Noé, Benoît, Ajzenberg, Nadine, Mazighi, Mikaël

“…Myeloproliferative neoplasms (MPNs) are characterized by a high rate of thrombotic complications that contribute to morbidity and mortality. MPN-related…”
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SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice by Willekens, Christophe, Laplane, Lucie, Dagher, Tracy, Benlabiod, Camelia, Papadopoulos, Nicolas, Lacout, Catherine, Rameau, Philippe, Catelain, Cyril, Alfaro, Alexia, Edmond, Valérie, Signolle, Nicolas, Marchand, Valentine, Droin, Nathalie, Hoogenboezem, Remco, Schneider, Rebekka K., Penson, Alex, Abdel-Wahab, Omar, Giraudier, Stephane, Pasquier, Florence, Marty, Caroline, Plo, Isabelle, Villeval, Jean-Luc, Constantinescu, Stefan N., Porteu, Françoise, Vainchenker, William, Solary, Eric

“…Heterozygous mutation targeting proline 95 in Serine/Arginine-rich Splicing Factor 2 (SRSF2) is associated with V617F mutation in Janus Activated Kinase 2…”
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PPARγ agonists promote the resolution of myelofibrosis in preclinical models by Lambert, Juliette, Saliba, Joseph, Calderon, Carolina, Sii-Felice, Karine, Salma, Mohammad, Edmond, Valérie, Alvarez, Jean-Claude, Delord, Marc, Marty, Caroline, Plo, Isabelle, Kiladjian, Jean-Jacques, Soler, Eric, Vainchenker, William, Villeval, Jean-Luc, Rousselot, Philippe, Prost, Stéphane

“…Myelofibrosis (MF) is a non–BCR-ABL myeloproliferative neoplasm associated with poor outcomes. Current treatment has little effect on the natural history of…”
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Targeting PP2A-dependent autophagy enhances sensitivity to ruxolitinib in JAK2V617F myeloproliferative neoplasms by Courdy, Charly, Platteeuw, Loïc, Ducau, Charlotte, De Araujo, Isabelle, Boet, Emeline, Sahal, Ambrine, Saland, Estelle, Edmond, Valérie, Tavitian, Suzanne, Bertoli, Sarah, Cougoul, Pierre, Granat, Fanny, Poillet, Laura, Marty, Caroline, Plo, Isabelle, Sarry, Jean-Emmanuel, Manenti, Stéphane, Mansat-De Mas, Véronique, Joffre, Carine

“…The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are chronic malignancies associated with high-risk complications and suboptimal responses…”
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Staphylococcus aureus-induced G2/M phase transition delay in host epithelial cells increases bacterial infective efficiency by Alekseeva, Ludmila, Rault, Lucie, Almeida, Sintia, Legembre, Patrick, Edmond, Valérie, Azevedo, Vasco, Miyoshi, Anderson, Even, Sergine, Taieb, Frédéric, Arlot-Bonnemains, Yannick, Le Loir, Yves, Berkova, Nadia

“…Staphylococcus aureus is a highly versatile, opportunistic pathogen and the etiological agent of a wide range of infections in humans and warm-blooded animals…”
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Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Can Regulate E2F1 Transcription Factor-mediated Control of Cyclin Transcription by Cartier, Jessy, Berthelet, Jean, Marivin, Arthur, Gemble, Simon, Edmond, Valérie, Plenchette, Stéphanie, Lagrange, Brice, Hammann, Arlette, Dupoux, Alban, Delva, Laurent, Eymin, Béatrice, Solary, Eric, Dubrez, Laurence

“…The inhibitor of apoptosis protein cIAP1 (cellular inhibitor of apoptosis protein-1) is a potent regulator of the tumor necrosis factor (TNF) receptor family…”
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Precise mapping of the CD95 pre-ligand assembly domain by Edmond, Valérie, Ghali, Benoist, Penna, Aubin, Taupin, Jean-Luc, Daburon, Sophie, Moreau, Jean-François, Legembre, Patrick

“…Pre-association of CD95 at the plasma membrane is mandatory for efficient death receptor signaling. This homotrimerization occurs through self-association of…”
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In Vivo Monitoring of Polycythemia Vera Development Reveals Carbonic Anhydrase 1 as a Potent Therapeutic Target by Murakami, Shohei, Barroca, Vilma, Perié, Leïla, Bravard, Anne, Bernardino-Sgherri, Jacqueline, Tisserand, Amandine, Devanand, Caroline, Edmond, Valérie, Magniez, Aurélie, Tenreira Bento, Sabrina, Torres, Claire, Pasquier, Florence, Plo, Isabelle, Vainchenker, William, Villeval, Jean-Luc, Roméo, Paul-Henri, Lewandowski, Daniel

“…Current murine models of myeloproliferative neoplasms (MPNs) cannot examine how MPNs progress from a single bone marrow source to the entire hematopoietic…”
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Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin by Edmond, Valerie, Moysan, Elodie, Khochbin, Saadi, Matthias, Patrick, Brambilla, Christian, Brambilla, Elisabeth, Gazzeri, Sylvie, Eymin, Beatrice

“…SRSF2 is a serine/arginine‐rich protein belonging to the family of SR proteins that are crucial regulators of constitutive and alternative pre‐mRNA splicing…”
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SRSF2 is required for sodium butyrate-mediated p21(WAF1) induction and premature senescence in human lung carcinoma cell lines by Edmond, Valerie, Brambilla, Christian, Brambilla, Elisabeth, Gazzeri, Sylvie, Eymin, Beatrice

“…Sodium butyrate (NaBu) is a histone deacetylase inhibitor that exhibits numerous antiproliferative activities in various cancer cell lines, notably through the…”
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In Vitro and In Vivo Interactions between Stromal and Leukemic Cells by Aouida, Amina, Beghi, Florian, Villeval, Jean-Luc, Edmond, Valérie, Vainchenker, William, Wittner, Monika, Louache, Fawzia, Haouas, Houda

“…Understanding the mechanisms underlying changes in the microenvironment caused by pathological cells is essential to develop new therapeutic strategies. Such…”
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In VitroandIn VivoInteractions between Stromal and Leukemic Cells by Aouida, Amina, Beghi, Florian, Villeval, Jean-Luc, Edmond, Valérie, Vainchenker, William, Wittner, Monika, Louache, Fawzia, Haouas, Houda

“…Understanding the mechanisms underlying changes in the microenvironment caused by pathological cells is essential to develop new therapeutic strategies. Such…”
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PPARγ agonists promote the resolution of myelofibrosis in preclinical models by Lambert, Juliette, Saliba, Joseph, Calderon, Carolina, Sii-Felice, Karine, Salma, Mohammad, Edmond, Valérie, Alvarez, Jean-Claude, Delord, Marc, Marty, Caroline, Plo, Isabelle, Kiladjian, Jean-Jacques, Soler, Eric, Vainchenker, William, Villeval, Jean-Luc, Rousselot, Philippe, Prost, Stéphane

“…I Myelofibrosis (MF) is a non-BCR-ABL myeloproliferative neoplasm associated with poor outcomes. Current treatment has little effect on the natural history of…”
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JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML by Dagher, Tracy, Maslah, Nabih, Edmond, Valérie, Cassinat, Bruno, Vainchenker, William, Giraudier, Stéphane, Pasquier, Florence, Verger, Emmanuelle, Niwa-Kawakita, Michiko, Lallemand-Breitenbach, Valérie, Plo, Isabelle, Kiladjian, Jean-Jacques, Villeval, Jean-Luc, de Thé, Hugues

“…Interferon α (IFNα) is used to treat JAK2V617F-driven myeloproliferative neoplasms (MPNs) but rarely clears the disease. We investigated the IFNα mechanism of…”
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Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin: Acetylation controls SRSF2 protein level by Edmond, Valerie, Moysan, Elodie, Khochbin, Saadi, Matthias, Patrick, Brambilla, Christian, Brambilla, Elisabeth, Gazzeri, Sylvie, Eymin, Beatrice

“…SRSF2 is a serine/arginine-rich protein belonging to the family of SR proteins that are crucial regulators of constitutive and alternative pre-mRNA splicing…”
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SRSF2-P95Hdelays Myelofibrosis Development through Altered JAK/STAT Signaling in JAK2-V617F Megakaryocytes by Willekens, Christophe, Laplane, Lucie, Dagher, Tracy, Benlabiod, Camélia, Lacout, Catherine, Rameau, Philippe, Catelain, Cyril, Alfaro, Alexia, Edmond, Valérie, Signolle, Nicolas, Silvin, Aymeric, Ginhoux, Florent, Marchand, Valentine, Droin, Nathalie, Hoogenboezem, Remco, Schneider, Rebekka K., Penson, Alexander V, Abdel-Wahab, Omar, Gonin, Patrick, Marty, Caroline, Plo, Isabelle, Villeval, Jean-Luc, Porteu, Francoise, Vainchenker, William, Solary, Eric

“…Background: The gain-of-function JAK2 V617F mutant is the most common driver mutation identified in myeloproliferative neoplasms (MPNs). Additional somatic…”
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Specific and Synergistic Targeting of JAK2V617F Cells By Interferon Alpha and Arsenic by Maslahl, Nabih, Dagher, Tracy, Edmond, Valérie, Cassinat, Bruno, Lallemand-Breitenbach, Valérie, Verger, Emmanuelle, Plo, Isabelle, Kiladjian, Jean-Jacques, Villeval, Jean-Luc, de Thé, Hugues

“…N.M. and T.D. co-first authors, J.L.V. and Hd.T. co-last authors Introduction: We have shown in clinical trials and preclinical studies on Myeloproliferative…”
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SRSF2 is required for sodium butyrate-mediated p21WAF1 induction and premature senescence in human lung carcinoma cell lines by Edmond, Valerie, Brambilla, Christian, Brambilla, Elisabeth, Gazzeri, Sylvie, Eymin, Beatrice

“…Sodium butyrate (NaBu) is a histone deacetylase inhibitor that exhibits numerous antiproliferative activities in various cancer cell lines, notably through the…”
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Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility by Edmond, V, Dufour, F, Poiroux, G, Shoji, K, Malleter, M, Fouqué, A, Tauzin, S, Rimokh, R, Sergent, O, Penna, A, Dupuy, A, Levade, T, Theret, N, Micheau, O, Ségui, B, Legembre, P

“…Epithelial-to-mesenchymal transition (EMT) promotes cell motility, which is important for the metastasis of malignant cells, and blocks CD95-mediated apoptotic…”
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