Search Results - "Edlund, Anna K."
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Plasma Apolipoprotein E3 and Glucose Levels Are Associated in APOE ɛ3/ɛ4 Carriers
Published in Journal of Alzheimer's disease (04-05-2021)“…Altered cerebral glucose metabolism, especially prominent in APOE ɛ4 carriers, occurs years prior to symptoms in Alzheimer's disease (AD). We recently found an…”
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Nuclear localization of amyloid-β precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis
Published in PloS one (2017)“…Fe65 is an adaptor protein involved in both processing and signaling of the Alzheimer-associated amyloid-β precursor protein, APP. Here, the subcellular…”
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Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice
Published in Molecular psychiatry (01-08-2022)“…Liver-generated plasma apolipoprotein E (apoE) does not enter the brain but nonetheless correlates with Alzheimer’s disease (AD) risk and AD biomarker levels…”
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Regional variability and solubility of apolipoprotein E in brains from patients with Alzheimer’s and Parkinson’s disease
Published in Alzheimer's & dementia (01-12-2020)“…Background APOEε4 is the strongest genetic risk factor for both Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB), and increases the severity of…”
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Effects of a high‐fat diet on the brain in FRGN mice with humanized livers: Molecular and cell biology/signal transduction
Published in Alzheimer's & dementia (01-12-2020)Get full text
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Effects of a high‐fat diet on the brain in FRGN mice with humanized livers
Published in Alzheimer's & dementia (01-12-2020)“…Background Diets rich in fat lead to high levels of circulating free fatty acids that induce systemic inflammation, which contribute to systemic insulin…”
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Nuclear localization of amyloid-[beta] precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis
Published in PloS one (21-03-2017)“…Fe65 is an adaptor protein involved in both processing and signaling of the Alzheimer-associated amyloid-[beta] precursor protein, APP. Here, the subcellular…”
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Effects of a liver APOEε4‐genotype on synaptic integrity, gliosis and insulin signaling in the brain
Published in Alzheimer's & dementia (01-12-2020)“…Background APOEε4 is the strongest genetic risk factor for AD[1]. Although plasma apoE does not cross the blood‐brain‐barrier[2], altered plasma apoE levels…”
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Nuclear localization of amyloid- square precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis
Published in PloS one (01-03-2017)“…Fe65 is an adaptor protein involved in both processing and signaling of the Alzheimer-associated amyloid-[Beta] precursor protein, APP. Here, the subcellular…”
Get full text
Journal Article