Search Results - "Edlich, Frank"

BCL-2 proteins and apoptosis: Recent insights and unknowns by Edlich, Frank

“…Proteins of the B-cell lymphoma-2 (BCL-2) family control the intrinsic apoptosis pathway. The pro-apoptotic BCL-2 proteins BAX and BAK can commit a cell to its…”
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Predisposition to Apoptosis in Hepatocellular Carcinoma: From Mechanistic Insights to Therapeutic Strategies by Marquardt, Jens U, Edlich, Frank

“…Hepatocellular carcinoma (HCC) ranks among the most rapidly evolving cancers in the Western world. The majority of HCCs develop on the basis of a chronic…”
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Differential retrotranslocation of mitochondrial Bax and Bak by Todt, Franziska, Cakir, Zeynep, Reichenbach, Frank, Emschermann, Frederic, Lauterwasser, Joachim, Kaiser, Andrea, Ichim, Gabriel, Tait, Stephen WG, Frank, Stephan, Langer, Harald F, Edlich, Frank

“…The Bcl‐2 proteins Bax and Bak can permeabilize the outer mitochondrial membrane and commit cells to apoptosis. Pro‐survival Bcl‐2 proteins control Bax by…”
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How Do Hexokinases Inhibit Receptor-Mediated Apoptosis? by Schoeniger, Axel, Wolf, Philipp, Edlich, Frank

“…The regulated cell death apoptosis enables redundant or compromised cells in ontogeny and homeostasis to remove themselves receptor-dependent after extrinsic…”
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Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis by Sauter, Reinhard J, Sauter, Manuela, Reis, Edimara S, Emschermann, Frederic N, Nording, Henry, Ebenhöch, Sonja, Kraft, Peter, Münzer, Patrick, Mauler, Maximilian, Rheinlaender, Johannes, Madlung, Johannes, Edlich, Frank, Schäffer, Tilman E, Meuth, Sven G, Dürschmied, Daniel, Geisler, Tobias, Borst, Oliver, Gawaz, Meinrad, Kleinschnitz, Christoph, Lambris, John D, Langer, Harald F

“…BACKGROUND:Platelets have distinct roles in the vascular system in that they are the major mediator of thrombosis, critical for restoration of tissue…”
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Apoptosis Regulation in Osteoarthritis and the Influence of Lipid Interactions by Werry, Frederike, Mazur, Emilia, Theyse, Lars F. H, Edlich, Frank

“…Osteoarthritis (OA) is one of the most common chronic diseases in human and animal joints. The joints undergo several morphological and histological changes…”
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The Soluble Form of Bax Regulates Mitochondrial Fusion via MFN2 Homotypic Complexes by Hoppins, Suzanne, Edlich, Frank, Cleland, Megan M., Banerjee, Soojay, McCaffery, J. Michael, Youle, Richard J., Nunnari, Jodi

“…In mammals, fusion of the mitochondrial outer membrane is controlled by two DRPs, MFN1 and MFN2, that function in place of a single outer membrane DRP, Fzo1 in…”
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The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation by Lauterwasser, Joachim, Todt, Franziska, Zerbes, Ralf M., Nguyen, Thanh Ngoc, Craigen, William, Lazarou, Michael, van der Laan, Martin, Edlich, Frank

“…The pro-apoptotic Bcl-2 protein Bax can permeabilize the outer mitochondrial membrane and therefore commit human cells to apoptosis. Bax is regulated by…”
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Mito-priming as a method to engineer Bcl-2 addiction by Lopez, Jonathan, Bessou, Margaux, Riley, Joel S., Giampazolias, Evangelos, Todt, Franziska, Rochegüe, Tony, Oberst, Andrew, Green, Douglas R., Edlich, Frank, Ichim, Gabriel, Tait, Stephen W. G.

“…Most apoptotic stimuli require mitochondrial outer membrane permeabilization (MOMP) in order to execute cell death. As such, MOMP is subject to tight control…”
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Parkin promotes proteasomal degradation of misregulated BAX by Cakir, Zeynep, Funk, Kathrin, Lauterwasser, Joachim, Todt, Franziska, Zerbes, Ralf M, Oelgeklaus, Aline, Tanaka, Atsushi, van der Laan, Martin, Edlich, Frank

“…The pro-apoptotic BCL-2 protein BAX commits human cells to apoptosis by permeabilizing the outer mitochondrial membrane. BAX activation has been suggested to…”
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Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA by Ma, Junhe, Edlich, Frank, Bermejo, Guillermo A., Norris, Kristi L., Youle, Richard J., Tjandra, Nico

“…The human protein Bax sits at a critical regulatory junction of apoptosis, or programmed cell death. Bax exists in equilibrium between cytosolic and…”
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Mitochondrial BAX Determines the Predisposition to Apoptosis in Human AML by Reichenbach, Frank, Wiedenmann, Cornelius, Schalk, Enrico, Becker, Diana, Funk, Kathrin, Scholz-Kreisel, Peter, Todt, Franziska, Wolleschak, Denise, Döhner, Konstanze, Marquardt, Jens U, Heidel, Florian, Edlich, Frank

“…Cell-to-cell variability in apoptosis signaling contributes to heterogenic responses to cytotoxic stress in clinically heterogeneous neoplasia, such as acute…”
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ZMYND10 functions in a chaperone relay during axonemal dynein assembly by Mali, Girish R, Yeyati, Patricia L, Mizuno, Seiya, Dodd, Daniel O, Tennant, Peter A, Keighren, Margaret A, Zur Lage, Petra, Shoemark, Amelia, Garcia-Munoz, Amaya, Shimada, Atsuko, Takeda, Hiroyuki, Edlich, Frank, Takahashi, Satoru, von Kreigsheim, Alex, Jarman, Andrew P, Mill, Pleasantine

“…Molecular chaperones promote the folding and macromolecular assembly of a diverse set of 'client' proteins. How ubiquitous chaperone machineries direct their…”
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From cell death to viral replication: the diverse functions of the membrane-associated FKBP38 by Edlich, Frank, Lücke, Christian

“…Highlights ► Structural insights suggest origin for the unusual functional properties of FKBP38. ► FKBP38 activation by calmodulin regulates Bcl-2 in neuronal…”
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Hypoxia-inducible Factor Prolyl-4-hydroxylase PHD2 Protein Abundance Depends on Integral Membrane Anchoring of FKBP38 by Barth, Sandra, Edlich, Frank, Berchner-Pfannschmidt, Utta, Gneuss, Silke, Jahreis, Günther, Hasgall, Philippe A., Fandrey, Joachim, Wenger, Roland H., Camenisch, Gieri

“…Prolyl-4-hydroxylase domain (PHD) proteins are 2-oxoglutarate and dioxygen-dependent enzymes that mediate the rapid destruction of hypoxia-inducible factor α…”
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Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development by Koszinowski, Sophie, La Padula, Veronica, Edlich, Frank, Krieglstein, Kerstin, Busch, Hauke, Boerries, Melanie

“…Avian ciliary ganglion (CG) development involves a transient execution phase of apoptosis controlling the final number of neurons, but the time-dependent…”
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The Peptidyl Prolyl cis/trans Isomerase FKBP38 Determines Hypoxia-Inducible Transcription Factor Prolyl-4-Hydroxylase PHD2 Protein Stability by Barth, Sandra, Nesper, Jutta, Hasgall, Philippe A., Wirthner, Renato, Nytko, Katarzyna J., Edlich, Frank, Katschinski, Dörthe M., Stiehl, Daniel P., Wenger, Roland H., Camenisch, Gieri

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Specific FKBP38 Inhibitor N-(N′,N′-Dimethylcarboxamidomethyl)cycloheximide Has Potent Neuroprotective and Neurotrophic Properties in Brain Ischemia by Edlich, Frank, Weiwad, Matthias, Wildemann, Dirk, Jarczowski, Franziska, Kilka, Susann, Moutty, Marie-Christine, Jahreis, Günther, Lücke, Christian, Schmidt, Werner, Striggow, Frank, Fischer, Gunter

“…FK506 and FK506-derived inhibitors of the FK506-binding protein (FKBP)-type peptidylprolyl cis/trans-isomerases (PPIase) display potent neuroprotective and…”
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The FKBP38 Catalytic Domain Binds to Bcl-2 via a Charge-sensitive Loop by Haupt, Katja, Jahreis, Günther, Linnert, Miriam, Maestre-Martínez, Mitcheell, Malešević, Miroslav, Pechstein, Arndt, Edlich, Frank, Lücke, Christian

“…FKBP38 is a regulator of the prosurvival protein Bcl-2, but in the absence of detailed structural insights, the molecular mechanism of the underlying…”
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The Bcl-2 Regulator FKBP38-Calmodulin-Ca2+ Is Inhibited by Hsp90 by Edlich, Frank, Erdmann, Frank, Jarczowski, Franziska, Moutty, Marie-Christine, Weiwad, Matthias, Fischer, Gunter

“…FKBP38 is a negative effector of the anti-apoptotic Bcl-2 protein in neuroblastoma cells. The interaction with Bcl-2 and the enzyme activity of FKBP38 depend…”
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