Search Results - "Edler, C"

Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization and Neurite Outgrowth from Human Pluripotent Stem Cells by Fligor, Clarisse M., Langer, Kirstin B., Sridhar, Akshayalakshmi, Ren, Yuan, Shields, Priya K., Edler, Michael C., Ohlemacher, Sarah K., Sluch, Valentin M., Zack, Donald J., Zhang, Chi, Suter, Daniel M., Meyer, Jason S.

“…Retinal organoids are three-dimensional structures derived from human pluripotent stem cells (hPSCs) which recapitulate the spatial and temporal…”
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Criminal corpse dismemberment in Hamburg, Germany from 1959 to 2016 by Wilke-Schalhorst, N., Schröder, A.S., Püschel, K., Edler, C.

“…•Cases of corpse dismemberment are rare events.•Corpse dismemberment is concentrated in densely built-up areas.•Multi-storey apartment buildings make the…”
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Ovarian hormones and binge eating: exploring associations in community samples by Klump, K L, Keel, P K, Culbert, K M, Edler, C

“…Significant associations between changes in ovarian hormones and binge eating are present across the menstrual cycle in women with bulimia nervosa. However, no…”
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New Arylthioindoles:  Potent Inhibitors of Tubulin Polymerization. 2. Structure−Activity Relationships and Molecular Modeling Studies by De Martino, Gabriella, Edler, Michael C, La Regina, Giuseppe, Coluccia, Antonio, Barbera, Maria Chiara, Barrow, Denise, Nicholson, Robert I, Chiosis, Gabriela, Brancale, Andrea, Hamel, Ernest, Artico, Marino, Silvestri, Romano

“…Arylthioindoles (ATIs) that possess a 3-methoxyphenylthio or a 3,5-dimethoxyphenylthio moiety at position 2 of the indole ring were effective tubulin assembly…”
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Arylthioindoles, Potent Inhibitors of Tubulin Polymerization by De Martino, Gabriella, La Regina, Giuseppe, Coluccia, Antonio, Edler, Michael C, Barbera, Maria Chiara, Brancale, Andrea, Wilcox, Elizabeth, Hamel, Ernest, Artico, Marino, Silvestri, Romano

“…Several arylthioindoles had excellent activity as inhibitors both of tubulin polymerization and of the growth of MCF-7 human breast carcinoma cells. Methyl…”
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Detection of blood and DNA traces after thermal exposure by Klein, A., Krebs, O., Gehl, A., Morgner, J., Reeger, L., Augustin, C., Edler, C.

“…The analysis of blood traces is often of significant reconstructive and evidence-gathering importance. Perpetrators deliberately set fires to destroy evidence…”
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Evidence for systematic autopsies in COVID-19 positive deceased: Case report of the first German investigated COVID-19 death by Fitzek, A., Sperhake, J., Edler, C., Schröder, A. S., Heinemann, A., Heinrich, F., Ron, A., Mushumba, H., Lütgehetmann, M., Püschel, K.

“…Forensic medicine and pathology involve specific health risks, whereby health workers are dealing with microorganisms, cells or parasites, which are referred…”
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Detection of blood and DNA traces after thermal exposure by Klein, Anke, Krebs, O., Gehl, A., Morgner, J., Reeger, L., Augustin, C., Edler, C.

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The effect of bleaching agents on the DNA analysis of bloodstains on different floor coverings by Edler, C., Krebs, O., Gehl, A., Palatzke, K., Tiedemann, N., Schröder, A. S., Klein, A.

“…Blood at crime scenes is one of the most significant traces of evidence in investigation proceedings. Cleaning up these traces with household cleaning…”
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COVID-19 lungs in post-mortem computed tomography by Kniep, I., Heinemann, A., Edler, C., Sperhake, J. P., Püschel, K., Ondruschka, B., Schröder, A. S.

“…Post-mortem computed tomography (PMCT) is a rapid and noninvasive diagnostic tool for important contributions to the identification of pulmonary findings in…”
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Astrocytes Regulate the Development and Maturation of Retinal Ganglion Cells Derived from Human Pluripotent Stem Cells by VanderWall, Kirstin B., Vij, Ridhima, Ohlemacher, Sarah K., Sridhar, Akshayalakshmi, Fligor, Clarisse M., Feder, Elyse M., Edler, Michael C., Baucum, Anthony J., Cummins, Theodore R., Meyer, Jason S.

“…Retinal ganglion cells (RGCs) form the connection between the eye and the brain, with this connectivity disrupted in numerous blinding disorders. Previous…”
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New Arylthioindoles and Related Bioisosteres at the Sulfur Bridging Group. 4. Synthesis, Tubulin Polymerization, Cell Growth Inhibition, and Molecular Modeling Studies by La Regina, Giuseppe, Sarkar, Taradas, Bai, Ruoli, Edler, Michael C, Saletti, Roberto, Coluccia, Antonio, Piscitelli, Francesco, Minelli, Lara, Gatti, Valerio, Mazzoccoli, Carmela, Palermo, Vanessa, Mazzoni, Cristina, Falcone, Claudio, Scovassi, Anna Ivana, Giansanti, Vincenzo, Campiglia, Pietro, Porta, Amalia, Maresca, Bruno, Hamel, Ernest, Brancale, Andrea, Novellino, Ettore, Silvestri, Romano

“…New arylthioindoles along with the corresponding ketone and methylene compounds were potent tubulin assembly inhibitors. As growth inhibitors of MCF-7 cells,…”
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Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites by Díaz, J Fernando, Buey, Rubén M, Calvo, Enrique, Barasoain, Isabel, Pineda, Oriol, Edler, Michael C, Matesanz, Ruth, Cerezo, Gemma, Vanderwal, Christopher D, Day, Billy W, Sorensen, Erik J, López, Juan Antonio, Andreu, José Manuel, Hamel, Ernest

“…Cyclostreptin (1), a natural product from Streptomyces sp. 9885, irreversibly stabilizes cellular microtubules, causes cell cycle arrest, evades drug…”
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Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction by Baucum, Anthony J., Jones, Lisa M., Rentz, Tyler J., Thang, Morrent, Morris, Cameron W., Salek, Asma B., Edler, Michael C., Hiday, Andrew C., Rose, Kristie L.

“…Signaling changes that occur in the striatum following the loss of dopamine neurons in the Parkinson disease (PD) are poorly understood. While increases in the…”
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Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity by Bai, Ruoli, Edler, Michael C, Bonate, Peter L, Copeland, Terry D, Pettit, George R, Ludueña, Richard F, Hamel, Ernest

“…Tasidotin, an oncolytic drug in phase II clinical trials, is a peptide analog of the antimitotic depsipeptide dolastatin 15. In tasidotin, the…”
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Synthesis and biological evaluation of (−)-dictyostatin and stereoisomers by Shin, Youseung, Fournier, Jean-Hugues, Brückner, Arndt, Madiraju, Charitha, Balachandran, Raghavan, Raccor, Brianne S., Edler, Michael C., Hamel, Ernest, Sikorski, Rachel P., Vogt, Andreas, Day, Billy W., Curran, Dennis P.

“…Total syntheses of (−)-dictyostatin, 6,16-bis- epi-dictyostatin, 6,14,19-tris- epi-dictyostatin, and a number of other isomers and analogs are reported. Three…”
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Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones by Raffa, Demetrio, Edler, Michael C., Daidone, Giuseppe, Maggio, Benedetta, Merickech, Mourad, Plescia, Salvatore, Schillaci, Domenico, Bai, Ruoli, Hamel, Ernest

“…In order to study the influence of 3-substitution on the cytotoxic activity of 2-styrylquinazolinones, new…”
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Cyclostreptin (FR182877), an Antitumor Tubulin-Polymerizing Agent Deficient in Enhancing Tubulin Assembly Despite Its High Affinity for the Taxoid Site by Edler, Michael C, Buey, Rubén M, Gussio, Rick, Marcus, Adam I, Vanderwal, Christopher D, Sorensen, Erik J, Díaz, J. Fernando, Giannakakou, Paraskevi, Hamel, Ernest

“…Cyclostreptin (FR182877), a bacterial natural product, was reported to have weak paclitaxel-like activity with tubulin but antitumor activity in vivo. We used…”
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Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents by Kong, Yali, Edler, Michael C., Hamel, Ernest, Britton-Jenkins, Asa R., Gillan, Omar, Mooberry, Susan L., Mu, David, Brown, Milton L.

“…Boronic acid analogs of combretastatin A-4 were designed and synthesized. The cytotoxicity study identified that several boronic acid analogs exhibited low…”
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Spinophilin regulates phosphorylation and interactions of the GluN2B subunit of the N‐methyl‐d‐aspartate receptor by Salek, Asma B., Edler, Michael C., McBride, Jonathon P., Baucum, Anthony J.

“…N‐methyl‐d‐Aspartate receptors (NMDARs) are abundant postsynaptic proteins that are critical for normal synaptic communication. NMDAR channel function is…”
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