Search Results - "Edland, Steven D."

Elucidating Molecular Phenotypes Caused by the SORL1 Alzheimer’s Disease Genetic Risk Factor Using Human Induced Pluripotent Stem Cells by Young, Jessica E., Boulanger-Weill, Jonathan, Williams, Daniel A., Woodruff, Grace, Buen, Floyd, Revilla, Arra C., Herrera, Cheryl, Israel, Mason A., Yuan, Shauna H., Edland, Steven D., Goldstein, Lawrence S.B.

“…Predisposition to sporadic Alzheimer’s disease (SAD) involves interactions between a person’s unique combination of genetic variants and the environment. The…”
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TDP‐43 Pathology Exacerbates Cognitive Decline in Primary Age‐Related Tauopathy by Smirnov, Denis S., Salmon, David P., Galasko, Douglas, Edland, Steven D., Pizzo, Donald P., Goodwill, Vanessa, Hiniker, Annie

“…Objective Primary age‐related tauopathy (PART) refers to tau neurofibrillary tangles restricted largely to the medial temporal lobe in the absence of…”
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Concepts for brain aging: resistance, resilience, reserve, and compensation by Montine, Thomas J, Cholerton, Brenna A, Corrada, Maria M, Edland, Steven D, Flanagan, Margaret E, Hemmy, Laura S, Kawas, Claudia H, White, Lon R

“…A primary goal of research in cognitive impairment and dementia is to understand how some individuals retain sufficient cognitive function for a fulfilling…”
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Pulse pressure in relation to tau-mediated neurodegeneration, cerebral amyloidosis, and progression to dementia in very old adults by Nation, Daniel A, Edmonds, Emily C, Bangen, Katherine J, Delano-Wood, Lisa, Scanlon, Blake K, Han, S Duke, Edland, Steven D, Salmon, David P, Galasko, Douglas R, Bondi, Mark W

“…Increased pulse pressure associated with age-related arterial stiffening increases risk for Alzheimer dementia but the mechanism responsible for this…”
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DNA methylation changes associated with Parkinson's disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood by Henderson-Smith, Adrienne, Fisch, Kathleen M., Hua, Jianping, Liu, Ganqiang, Ricciardelli, Eugenia, Jepsen, Kristen, Huentelman, Mathew, Stalberg, Gabriel, Edland, Steven D., Scherzer, Clemens R., Dunckley, Travis, Desplats, Paula

“…Parkinson's Disease (PD) is a common neurodegenerative disorder currently diagnosed based on the presentation of characteristic movement symptoms…”
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Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients by Orrù, Christina D, Soldau, Katrin, Cordano, Christian, Llibre-Guerra, Jorge, Green, Ari J, Sanchez, Henry, Groveman, Bradley R, Edland, Steven D, Safar, Jiri G, Lin, Jonathan H, Caughey, Byron, Geschwind, Michael D, Sigurdson, Christina J

“…Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common prion disease in humans and has been iatrogenically transmitted through corneal graft…”
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Power calculations for clinical trials in Alzheimer's disease by Ard, M Colin, Edland, Steven D

“…The Alzheimer research community is actively pursuing novel biomarker and other biologic measures to characterize disease progression or to use as outcome…”
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Neuropsychological Criteria for Mild Cognitive Impairment in the Framingham Heart Study's Old-Old by Wong, Christina G, Thomas, Kelsey R, Edmonds, Emily C, Weigand, Alexandra J, Bangen, Katherine J, Eppig, Joel S, Jak, Amy J, Devine, Sherral A, Delano-Wood, Lisa, Libon, David J, Edland, Steven D, Au, Rhoda, Bondi, Mark W

“…Mild cognitive impairment (MCI) lacks a "gold standard" operational definition. The Jak/Bondi actuarial neuropsychological criteria for MCI are associated with…”
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Artificially low mild cognitive impairment to normal reversion rate in the Alzheimer's Disease Neuroimaging Initiative by Thomas, Kelsey R., Eppig, Joel S., Weigand, Alexandra J., Edmonds, Emily C., Wong, Christina G., Jak, Amy J., Delano-Wood, Lisa, Galasko, Douglas R., Salmon, David P., Edland, Steven D., Bondi, Mark W.

“…We examined reasons for low mild cognitive impairment (MCI)-to-cognitively normal (CN) reversion rates in the Alzheimer's Disease Neuroimaging Initiative…”
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Sex differences in Alzheimer's disease: plasma MMP-9 and markers of disease severity by Tsiknia, Amaryllis A, Sundermann, Erin E, Reas, Emilie T, Edland, Steven D, Brewer, James B, Galasko, Douglas, Banks, Sarah J

“…Studies have reported higher plasma matrix metalloproteinase-9 (MMP-9) levels in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Despite evidence…”
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TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study by Flanagan, Margaret E, Cholerton, Brenna, Latimer, Caitlin S, Hemmy, Laura S, Edland, Steven D, Montine, Kathleen S, White, Lon R, Montine, Thomas J

“…Transactive response binding protein-43 (TDP-43) cytoplasmic neuronal and glial aggregates (pathologic TDP-43) have been described in multiple brain diseases…”
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ADCS prevention instrument project : Assessment of instrumental activities of daily living for community-dwelling elderly individuals in dementia prevention clinical trials by GALASKO, Douglas, BENNETT, David A, SANO, Mary, MARSON, Daniel, KAYE, Jeff, EDLAND, Steven D

“…In primary prevention trials for Alzheimer disease, the inception cohort typically has normal or minimally impaired complex activities of daily living (ADL)…”
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Community memory screening as a strategy for recruiting older adults into Alzheimer's disease research by Peavy, Guerry M, Jenkins, Cecily W, Little, Emily A, Gigliotti, Christina, Calcetas, Amanda, Edland, Steven D, Brewer, James B, Galasko, Douglas, Salmon, David P

“…Growing awareness of Alzheimer's disease (AD) has prompted a demand for quick and effective ways to screen for memory loss and cognitive decline in large…”
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Subjective Memory Complaints Are Associated with Diurnal Measures of Salivary Cortisol in Cognitively Intact Older Adults by Peavy, Guerry M., Ph.D, Santiago, Deliamille Pérez, B.S, Edland, Steven D., Ph.D

“…Objective To investigate the relationship between subjective memory complaints (SMC) and the stress hormone cortisol using diurnal measures in older,…”
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Differential blood DNA methylation across Lewy body dementias by Nasamran, Chanond A., Sachan, Anubhav Nikunj Singh, Mott, Jennifer, Kuras, Yuliya I., Scherzer, Clemens R., Study, Harvard Biomarkers, Ricciardelli, Eugenia, Jepsen, Kristen, Edland, Steven D., Fisch, Kathleen M., Desplats, Paula

“…Introduction Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are characterized by cognitive alterations, visual hallucinations, and…”
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Neuropsychiatric Features of Frontal Lobe Dysfunction in Autopsy-Confirmed Patients with Lewy Bodies and “Pure” Alzheimer Disease by Peavy, Guerry M., Ph.D, Salmon, David P., Ph.D, Edland, Steven D., Ph.D, Tam, Steven, M.D, Hansen, Lawrence A., M.D, Masliah, Eliezer, M.D, Galasko, Douglas, M.D, Hamilton, Joanne M., Ph.D

“…Objective To compare patients with autopsy-confirmed Alzheimer disease (AD) and dementia with Lewy bodies (DLB) on the frequency of behaviors related to…”
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Semorinemab in Mild-to-Moderate Alzheimer Disease: A Glimmer of Hope Though Cautions Remain by Edland, Steven D, Llibre-Guerra, Jorge J

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Potential implications of practice effects in Alzheimer's disease prevention trials by Jacobs, Diane M., Ard, M. Colin, Salmon, David P., Galasko, Douglas R., Bondi, Mark W., Edland, Steven D.

“…Practice effects (PEs) present a potential confound in clinical trials with cognitive outcomes. A single-blind placebo run-in design, with repeated cognitive…”
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Sex differences in plasma p-tau181 associations with Alzheimer’s disease biomarkers, cognitive decline, and clinical progression by Tsiknia, Amaryllis A., Edland, Steven D., Sundermann, Erin E., Reas, Emilie T., Brewer, James B., Galasko, Douglas, Banks, Sarah J.

“…Studies have shown that women on the Alzheimer’s disease (AD) continuum have more pathological tau in the brain and cerebrospinal fluid (CSF), than men. Some…”
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United States medical students' knowledge of Alzheimer disease by Nagle, Brian J, Usita, Paula M, Edland, Steven D

“…A knowledge gap exists between general physicians and specialists in diagnosing and managing Alzheimer disease (AD). This gap is concerning due to the…”
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