Search Results - "Edith Swann"
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Prospective Study of Acute HIV-1 Infection in Adults in East Africa and Thailand
Published in The New England journal of medicine (02-06-2016)“…Acute human immunodeficiency virus type 1 (HIV-1) infection is a major contributor to transmission of HIV-1. An understanding of acute HIV-1 infection may be…”
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Antibody Fc effector functions and IgG3 associate with decreased HIV-1 risk
Published in The Journal of clinical investigation (01-11-2019)“…HVTN 505 is a preventative vaccine efficacy trial testing DNA followed by recombinant adenovirus serotype 5 (rAd5) in circumcised, Ad5-seronegative men and…”
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Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa
Published in Science translational medicine (18-09-2019)“…One of the most successful HIV vaccines to date, the RV144 vaccine tested in Thailand, demonstrated correlates of protection including cross-clade V1V2…”
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Does per‐act HIV‐1 transmission risk through anal sex vary by gender? An updated systematic review and meta‐analysis
Published in American journal of reproductive immunology (1989) (01-11-2018)“…Quantifying HIV‐1 transmission risk per‐act of anal intercourse (AI) is important for HIV‐1 prevention. We updated previous reviews by searching Medline and…”
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Adults on pre-exposure prophylaxis (tenofovir-emtricitabine) have faster clearance of anti-HIV monoclonal antibody VRC01
Published in Nature communications (28-11-2023)“…Broadly neutralizing monoclonal antibodies (mAbs) are being developed for HIV-1 prevention. Hence, these mAbs and licensed oral pre-exposure prophylaxis (PrEP)…”
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Induction of HIV-1–Specific Mucosal Immune Responses Following Intramuscular Recombinant Adenovirus Serotype 26 HIV-1 Vaccination of Humans
Published in The Journal of infectious diseases (15-02-2015)“…Background. Defining mucosal immune responses and inflammation to candidate human immunodeficiency virus type 1 (HIV-1) vaccines represents a current research…”
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HIV incidence and its associated factors among young adults with multiple sexual partners in Maputo, Mozambique: a vaccine preparedness study
Published in BMC public health (02-10-2024)“…Sub-Saharan Africa has a high burden of HIV, particularly among female sex workers (FSW) and men who have sex with men (MSM). Future clinical trials to…”
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Transient Peripheral Immune Activation follows Elective Sigmoidoscopy or Circumcision in a Cohort Study of MSM at Risk of HIV Infection
Published in PloS one (18-08-2016)“…Rectal and genital sampling in HIV prevention trials permits assessments at the site of HIV entry. Yet the safety and acceptability of circumcision and…”
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Vaccination With Heterologous HIV-1 Envelope Sequences and Heterologous Adenovirus Vectors Increases T-Cell Responses to Conserved Regions: HVTN 083
Published in The Journal of infectious diseases (15-02-2016)“…Background. Increasing the breadth of human immunodeficiency virus type 1 (HIV-1) vaccine-elicited immune responses or targeting conserved regions may improve…”
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Helios expressing regulatory T cells are correlated with decreased IL-2 producing CD8 T cells and antibody diversity in Mozambican individuals living chronically with HIV-1
Published in BMC immunology (14-03-2022)“…Human immunodeficiency virus type 1 (HIV-1) causes impairment of T and B cell responses, which begins during the acute phase of infection and is not completely…”
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First-in-Human Evaluation of a Hexon Chimeric Adenovirus Vector Expressing HIV-1 Env (IPCAVD 002)
Published in The Journal of infectious diseases (01-10-2014)“…Background. We report the first-in-human safety and immunogenicity assessment of a prototype hexon chimeric adenovirus (Ad) serotype 5 (Ad5) vector containing…”
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How common and frequent is heterosexual anal intercourse among South Africans? A systematic review and meta‐analysis
Published in Journal of the International AIDS Society (01-03-2017)“…Background: HIV is transmitted more effectively during anal intercourse (AI) than vaginal intercourse (VI). However, patterns of heterosexual AI practice and…”
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Conceptual framework for behavioral and social science in HIV vaccine clinical research
Published in Vaccine (13-10-2011)“…Abstract HIV vaccine clinical research occurs within a context where biomedical science and social issues are interlinked. Previous HIV vaccine research has…”
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Behavioral and social science in HIV vaccine clinical research: Workshop report
Published in Vaccine (21-03-2011)“…Abstract In May 2009, a workshop was held in Washington DC to identify ways in which HIV vaccine clinical research could benefit from and better incorporate…”
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Intramuscular and Intradermal Electroporation of HIV-1 PENNVAX-GP ® DNA Vaccine and IL-12 Is Safe, Tolerable, Acceptable in Healthy Adults
Published in Vaccines (Basel) (07-12-2020)“…Several techniques are under investigation to improve the immunogenicity of HIV-1 DNA vaccine candidates. DNA vaccines are advantageous due to their ease of…”
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Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19)
Published in The Lancet (British edition) (21-07-2018)“…More than 1·8 million new cases of HIV-1 infection were diagnosed worldwide in 2016. No licensed prophylactic HIV-1 vaccine exists. A major limitation to date…”
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Final Analysis of Efficacy and Safety of Single-Dose Ad26.COV2.S
Published in The New England journal of medicine (03-03-2022)“…The randomized trial assessing the efficacy of a single injection of the Ad26.COV2.S showed 56.3% vaccine efficacy beginning 14 days after injection and 52.9%…”
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Advancing long-acting and extended delivery HIV prevention and treatment regimens through behavioural science: NIH workshop directions
Published in AIDS (London) (01-07-2021)Get full text
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Advancing long-acting and extended delivery HIV prevention and treatment regimens through behavioral science: NIH workshop directions
Published in AIDS (London) (10-03-2021)Get full text
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First-in-Human Evaluation of the Safety and Immunogenicity of a Recombinant Adenovirus Serotype 26 HIV-1 Env Vaccine (IPCAVD 001)
Published in The Journal of infectious diseases (15-01-2013)“…Background. We report the first-in-human safety and immunogenicity assessment of a prototype Ad26 vector-based human immunodeficiency virus (HIV) vaccine in…”
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