Search Results - "Edgley, Mark L."

Recompleting the Caenorhabditis elegans genome by Yoshimura, Jun, Ichikawa, Kazuki, Shoura, Massa J, Artiles, Karen L, Gabdank, Idan, Wahba, Lamia, Smith, Cheryl L, Edgley, Mark L, Rougvie, Ann E, Fire, Andrew Z, Morishita, Shinichi, Schwarz, Erich M

“…was the first multicellular eukaryotic genome sequenced to apparent completion. Although this assembly employed a standard strain (N2), it used sequence data…”
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CRISPR/Cas9 Methodology for the Generation of Knockout Deletions in Caenorhabditis elegans by Au, Vinci, Li-Leger, Erica, Raymant, Greta, Flibotte, Stephane, Chen, George, Martin, Kiana, Fernando, Lisa, Doell, Claudia, Rosell, Federico I, Wang, Su, Edgley, Mark L, Rougvie, Ann E, Hutter, Harald, Moerman, Donald G

“…The Gene Knockout Consortium is tasked with obtaining null mutations in each of the more than 20,000 open reading frames (ORFs) of this organism. To date,…”
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Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity by Mathew, Mark D, Mathew, Neal D, Miller, Angela, Simpson, Mike, Au, Vinci, Garland, Stephanie, Gestin, Marie, Edgley, Mark L, Flibotte, Stephane, Balgi, Aruna, Chiang, Jennifer, Giaever, Guri, Dean, Pamela, Tung, Audrey, Roberge, Michel, Roskelley, Calvin, Forge, Tom, Nislow, Corey, Moerman, Donald

“…The lack of new anthelmintic agents is of growing concern because it affects human health and our food supply, as both livestock and plants are affected. Two…”
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PhenoMIP: High-Throughput Phenotyping of Diverse Caenorhabditis elegans Populations via Molecular Inversion Probes by Mok, Calvin, Belmarez, Gabriella, Edgley, Mark L, Moerman, Donald G, Waterston, Robert H

“…Abstract Whether generated within a lab setting or isolated from the wild, variant alleles continue to be an important resource for decoding gene function in…”
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Copy number variation in the genomes of twelve natural isolates of Caenorhabditis elegans by Maydan, Jason S, Lorch, Adam, Edgley, Mark L, Flibotte, Stephane, Moerman, Donald G

“…Copy number variation is an important component of genetic variation in higher eukaryotes. The extent of natural copy number variation in C. elegans is unknown…”
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The Molecular Chaperone HSP90 Promotes Notch Signaling in the Germline of Caenorhabditis elegans by Lissemore, James L, Connors, Elyse, Liu, Ying, Qiao, Li, Yang, Bing, Edgley, Mark L, Flibotte, Stephane, Taylor, Jon, Au, Vinci, Moerman, Donald G, Maine, Eleanor M

“…In a genetic screen to identify genes that promote GLP-1/Notch signaling in germline stem cells, we found a single mutation, , defining a gene called causes…”
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High-throughput fluorescence-based isolation of live C. elegans larvae by Fernandez, Anita G, Bargmann, Bastiaan O R, Mis, Emily K, Edgley, Mark L, Birnbaum, Kenneth D, Piano, Fabio

“…For the nematode Caenorhabditis elegans , automated selection of animals of specific genotypes from a mixed pool has become essential for genetic interaction…”
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Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans by Gems, David, Sutton, Amy J, Sundermeyer, Mark L, Albert, Patrice S, King, Kevin V, Edgley, Mark L, Larsen, Pamela L, Riddle, Donald L

“…The nematode Caenorhabditis elegans responds to overcrowding and scarcity of food by arresting development as a dauer larva, a nonfeeding, long-lived,…”
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Multiple UDP glycosyltransferases modulate benzimidazole drug sensitivity in the nematode Caenorhabditis elegans in an additive manner by Sharma, Nidhi, Au, Vinci, Martin, Kiana, Edgley, Mark L., Moerman, Don, Mains, Paul E., Gilleard, John S.

“…[Display omitted] •Multiple ugt genes modulate benzimidazole sensitivity in Caenorhabditis elegans.•Genetic mutations revealed that loss of ugt-9 and ugt-11…”
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Rapid Increase in frequency of gene copy-number variants during experimental evolution in Caenorhabditis elegans by Farslow, James C, Lipinski, Kendra J, Packard, Lucille B, Edgley, Mark L, Taylor, Jon, Flibotte, Stephane, Moerman, Donald G, Katju, Vaishali, Bergthorsson, Ulfar

“…Gene copy-number variation (CNVs), which provides the raw material for the evolution of novel genes, is widespread in natural populations. We investigated…”
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Whole-genome profiling of mutagenesis in Caenorhabditis elegans by Flibotte, Stephane, Edgley, Mark L, Chaudhry, Iasha, Taylor, Jon, Neil, Sarah E, Rogula, Aleksandra, Zapf, Rick, Hirst, Martin, Butterfield, Yaron, Jones, Steven J, Marra, Marco A, Barstead, Robert J, Moerman, Donald G

“…Deep sequencing offers an unprecedented view of an organism's genome. We describe the spectrum of mutations induced by three commonly used mutagens: ethyl…”
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MIP-MAP: High-Throughput Mapping of Caenorhabditis elegans Temperature-Sensitive Mutants via Molecular Inversion Probes by Mok, Calvin A, Au, Vinci, Thompson, Owen A, Edgley, Mark L, Gevirtzman, Louis, Yochem, John, Lowry, Joshua, Memar, Nadin, Wallenfang, Matthew R, Rasoloson, Dominique, Bowerman, Bruce, Schnabel, Ralf, Seydoux, Geraldine, Moerman, Donald G, Waterston, Robert H

“…Mutants remain a powerful means for dissecting gene function in model organisms such as Massively parallel sequencing has simplified the detection of variants…”
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Sequenced Breakpoints of Crossover Suppressor/Inversion qC1 by Edgley, Mark L, Flibotte, Stephane, Moerman, Donald G

“…We used whole-genome sequencing (WGS) data from a number of balanced lethal strains in to show that the crossover suppressor is an inversion. The rearrangement…”
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Efficient high-resolution deletion discovery in Caenorhabditis elegans by array comparative genomic hybridization by Maydan, Jason S, Flibotte, Stephane, Edgley, Mark L, Lau, Joanne, Selzer, Rebecca R, Richmond, Todd A, Pofahl, Nathan J, Thomas, James H, Moerman, Donald G

“…We have developed array Comparative Genomic Hybridization for Caenorhabditis elegans as a means of screening for novel induced deletions in this organism. We…”
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Rapid High Resolution Single Nucleotide Polymorphism-Comparative Genome Hybridization Mapping in Caenorhabditis elegans by Flibotte, Stephane, Edgley, Mark L, Maydan, Jason, Taylor, Jon, Zapf, Rick, Waterston, Robert, Moerman, Donald G

“…We have developed a significantly improved and simplified method for high-resolution mapping of phenotypic traits in Caenorhabditis elegans using a combination…”
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De Novo Identification of Single Nucleotide Mutations in Caenorhabditis elegans Using Array Comparative Genomic Hybridization by Maydan, Jason S, Okada, H. Mark, Flibotte, Stephane, Edgley, Mark L, Moerman, Donald G

“…Array comparative genomic hybridization (aCGH) has been used primarily to detect copy-number variants between two genomes. Here we report using aCGH to detect…”
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Systematic Interactome Mapping and Genetic Perturbation Analysis of a C. elegans TGF-β Signaling Network by Tewari, Muneesh, Hu, Patrick J., Ahn, Jin Sook, Ayivi-Guedehoussou, Nono, Vidalain, Pierre-Olivier, Li, Siming, Milstein, Stuart, Armstrong, Chris M., Boxem, Mike, Butler, Maurice D., Busiguina, Svetlana, Rual, Jean-François, Ibarrola, Nieves, Chaklos, Sabrina T., Bertin, Nicolas, Vaglio, Philippe, Edgley, Mark L., King, Kevin V., Albert, Patrice S., Vandenhaute, Jean, Pandey, Akhilesh, Riddle, Donald L., Ruvkun, Gary, Vidal, Marc

“…To initiate a system-level analysis of C. elegans DAF-7/TGF-β signaling, we combined interactome mapping with single and double genetic perturbations. Yeast…”
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Genetic balancers by Edgley, Mark L, Baillie, David L, Riddle, Donald L, Rose, Ann M

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