Search Results - "Edgerton, Mira"

Candida albicans biofilm development is governed by cooperative attachment and adhesion maintenance proteins by McCall, Andrew D., Pathirana, Ruvini U., Prabhakar, Aditi, Cullen, Paul J., Edgerton, Mira

“…The opportunistic fungal pathogen Candida albicans is capable of adhering to the oral mucosa despite forces created by salivary flow. Although many fungal…”
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Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition by Kumar, Rohitashw, Breindel, Christine, Saraswat, Darpan, Cullen, Paul J., Edgerton, Mira

“…Candida albicans is an opportunistic fungal pathogen colonizing the oral cavity. C . albicans secreted aspartic protease Sap6 is important for virulence during…”
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Candida glabrata Binding to Candida albicans Hyphae Enables Its Development in Oropharyngeal Candidiasis by Tati, Swetha, Davidow, Peter, McCall, Andrew, Hwang-Wong, Elizabeth, Rojas, Isolde G, Cormack, Brendan, Edgerton, Mira

“…Pathogenic mechanisms of Candida glabrata in oral candidiasis, especially because of its inability to form hyphae, are understudied. Since both Candida…”
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Candida albicans Sfl1/Sfl2 regulatory network drives the formation of pathogenic microcolonies by McCall, Andrew D, Kumar, Rohitashw, Edgerton, Mira

“…Candida albicans is an opportunistic fungal pathogen that can infect oral mucosal surfaces while being under continuous flow from saliva. Under specific…”
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Candida albicans Sap6 Initiates Oral Mucosal Inflammation via the Protease Activated Receptor PAR2 by Kumar, Rohitashw, Rojas, Isolde Gina, Edgerton, Mira

“…Sap6, a secreted aspartyl protease (Sap), contributes to fungal virulence in oral candidiasis. Beside its protease activity, Sap6 contains RGD (RGDRGD) motif…”
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Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis by Conti, Heather R, Shen, Fang, Nayyar, Namrata, Stocum, Eileen, Sun, Jianing N, Lindemann, Matthew J, Ho, Allen W, Hai, Justine Hoda, Yu, Jeffrey J, Jung, Ji Won, Filler, Scott G, Masso-Welch, Patricia, Edgerton, Mira, Gaffen, Sarah L

“…The commensal fungus Candida albicans causes oropharyngeal candidiasis (OPC; thrush) in settings of immunodeficiency. Although disseminated, vaginal, and oral…”
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Candida albicans Flu1-Mediated Efflux of Salivary Histatin 5 Reduces Its Cytosolic Concentration and Fungicidal Activity by Li, Rui, Kumar, Rohitashw, Tati, Swetha, Puri, Sumant, Edgerton, Mira

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An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses by Hampe, Irene A I, Friedman, Justin, Edgerton, Mira, Morschhäuser, Joachim

“…The opportunistic fungal pathogen Candida albicans frequently produces genetically altered variants to adapt to environmental changes and new host niches in…”
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Human β-Defensins Kill Candida albicans in an Energy-Dependent and Salt-Sensitive Manner without Causing Membrane Disruption by VYLKOVA, Slavena, NAYYAR, Namrata, WANSHENG LI, EDGERTON, Mira

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Filamentous Non- albicans Candida Species Adhere to Candida albicans and Benefit From Dual Biofilm Growth by Pathirana, Ruvini U, McCall, Andrew D, Norris, Hannah L, Edgerton, Mira

“…Non- species (NACS) are often isolated along with in cases of oropharyngeal candidiasis. readily forms biofilms in conjunction with other oral microbiota…”
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Histatin 5-Spermidine Conjugates Have Enhanced Fungicidal Activity and Efficacy as a Topical Therapeutic for Oral Candidiasis by TATI, Swetha, RUI LI, PURI, Sumant, KUMAR, Rohitashw, DAVIDOW, Peter, EDGERTON, Mira

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Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis by Puri, Sumant, Kumar, Rohitashw, Chadha, Sonia, Tati, Swetha, Conti, Heather R, Hube, Bernhard, Cullen, Paul J, Edgerton, Mira

“…Perception of external stimuli and generation of an appropriate response are crucial for host colonization by pathogens. In pathogenic fungi, mitogen activated…”
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A Novel Role for Histatin 5 in Combination with Zinc to Promote Commensalism in C. albicans Survivor Cells by Norris, Hannah L, Kumar, Rohitashw, Edgerton, Mira

“…is maintained as a commensal by immune mechanisms at the oral epithelia. Oral antifungal peptide Histatin 5 (Hst 5) may function in innate immunity, but the…”
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Human Salivary Protein Histatin 5 Has Potent Bactericidal Activity against ESKAPE Pathogens by Du, Han, Puri, Sumant, McCall, Andrew, Norris, Hannah L, Russo, Thomas, Edgerton, Mira

“…ESKAPE ( , , , , , and species) pathogens have characteristic multiple-drug resistance and cause an increasing number of nosocomial infections worldwide…”
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Host cell invasion and virulence mediated by Candida albicans Ssa1 by Sun, Jianing N, Solis, Norma V, Phan, Quynh T, Bajwa, Jashanjot S, Kashleva, Helena, Thompson, Angela, Liu, Yaoping, Dongari-Bagtzoglou, Anna, Edgerton, Mira, Filler, Scott G

“…Candida albicans Ssa1 and Ssa2 are members of the HSP70 family of heat shock proteins that are expressed on the cell surface and function as receptors for…”
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Real-Time Approach to Flow Cell Imaging of Candida albicans Biofilm Development by McCall, Andrew, Edgerton, Mira

“…The ability of to form biofilms is a virulence factor that allows tissue attachment and subsequent infection of host tissues. Fungal biofilms have been…”
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Histatin 5 Uptake by Candida albicans Utilizes Polyamine Transporters Dur3 and Dur31 Proteins by Kumar, Rohitashw, Chadha, Sonia, Saraswat, Darpan, Bajwa, Jashanjot Singh, Li, Rui A., Conti, Heather R., Edgerton, Mira

“…Histatin 5 (Hst 5) is a salivary gland-secreted cationic peptide with potent fungicidal activity against Candida albicans. Hst 5 kills fungal cells following…”
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Zinc Binding by Histatin 5 Promotes Fungicidal Membrane Disruption in C. albicans and C. glabrata by Norris, Hannah L, Kumar, Rohitashw, Ong, Chih Yean, Xu, Ding, Edgerton, Mira

“…Histatin 5 (Hst 5) is an antimicrobial peptide produced in human saliva with antifungal activity for opportunistic pathogen Candida albicans. Hst 5 binds to…”
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Author Correction: Candida albicans biofilm development is governed by cooperative attachment and adhesion maintenance proteins by McCall, Andrew D., Pathirana, Ruvini U., Prabhakar, Aditi, Cullen, Paul J., Edgerton, Mira

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Aggregate Filamentous Growth Responses in Yeast by Chow, Jacky, Dionne, Heather M, Prabhakar, Aditi, Mehrotra, Amit, Somboonthum, Jenn, Gonzalez, Beatriz, Edgerton, Mira, Cullen, Paul J

“…Many fungal species, including pathogens, undergo a morphogenetic response called filamentous growth, where cells differentiate into a specialized cell type to…”
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