Search Results - "Edgar, T."

Adaptive mechanisms driving maladaptive pain: how chronic ongoing activity in primary nociceptors can enhance evolutionary fitness after severe injury by Walters, Edgar T

“…Chronic pain is considered maladaptive by clinicians because it provides no apparent protective or recuperative benefits. Similarly, evolutionary speculations…”
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Neuroinflammatory contributions to pain after SCI: Roles for central glial mechanisms and nociceptor-mediated host defense by Walters, Edgar T.

“…Neuropathic pain after spinal cord injury (SCI) is common, often intractable, and can be severely debilitating. A number of mechanisms have been proposed for…”
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Nociceptive Biology of Molluscs and Arthropods: Evolutionary Clues About Functions and Mechanisms Potentially Related to Pain by Walters, Edgar T

“…Important insights into the selection pressures and core molecular modules contributing to the evolution of pain-related processes have come from studies of…”
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How is chronic pain related to sympathetic dysfunction and autonomic dysreflexia following spinal cord injury? by Walters, Edgar T

“…Abstract Autonomic dysreflexia (AD) and neuropathic pain occur after severe injury to higher levels of the spinal cord. Mechanisms underlying these problems…”
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Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587 by Figueroa, Javier, Phillips, Lynette M, Shahar, Tal, Hossain, Anwar, Gumin, Joy, Kim, Hoon, Bean, Andrew J, Calin, George A, Fueyo, Juan, Walters, Edgar T, Kalluri, Raghu, Verhaak, Roel G, Lang, Frederick F

“…Tumor-stromal communications impact tumorigenesis in ways that are incompletely understood. Here, we show that glioma-associated human mesenchymal stem cells…”
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What's up with the decline in beans? Are there simple tests to identify people with HIV at risk for chronic kidney disease? by Abdel-Hameed, Enass A, Overton, Edgar T

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Evolution of mechanisms and behaviour important for pain by Walters, Edgar T, Williams, Amanda C de C

“…Our understanding of the biology of pain is limited by our ignorance about its evolution. We know little about how states in other species showing various…”
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Molecular and cellular mechanisms that initiate pain and itch by Luo, Jialie, Feng, Jing, Liu, Shenbin, Walters, Edgar T, Hu, Hongzhen

“…Somatosensory neurons mediate our sense of touch. They are critically involved in transducing pain and itch sensations under physiological and pathological…”
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Nociceptive Sensitization Reduces Predation Risk by Crook, Robyn J., Dickson, Katharine, Hanlon, Roger T., Walters, Edgar T.

“…Sublethal injury triggers long-lasting sensitization of defensive responses in most species examined, suggesting the involvement of powerful evolutionary…”
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Is it possible to get a two-for-one? Can we slow cognitive decline by treating vascular disease risk factors? by Agnihotri, Shruti P., Overton, Edgar T.

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Readiness of nociceptor cell bodies to generate spontaneous activity results from background activity of diverse ion channels and high input resistance by Tian, Jinbin, Bavencoffe, Alexis G, Zhu, Michael X, Walters, Edgar T

“…Nociceptor cell bodies generate "spontaneous" discharge that can promote ongoing pain in persistent pain conditions. Little is known about the underlying…”
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Alternative strategies of posttransplant influenza vaccination in adult solid organ transplant recipients by Haddadin, Zaid, Krueger, Karen, Thomas, Lora D., Overton, Edgar T., Ison, Michael, Halasa, Natasha

“…Solid organ transplant (SOT) recipients are at increased risk of influenza disease and associated complications. The mainstay of prevention is the annual…”
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Long-acting cabotegravir and rilpivirine dosed every 2 months in adults with HIV-1 infection (ATLAS-2M), 48-week results: a randomised, multicentre, open-label, phase 3b, non-inferiority study by Overton, Edgar T, Richmond, Gary, Rizzardini, Giuliano, Jaeger, Hans, Orrell, Catherine, Nagimova, Firaya, Bredeek, Fritz, García Deltoro, Miguel, Swindells, Susan, Andrade-Villanueva, Jaime Federico, Wong, Alexander, Khuong-Josses, Marie-Aude, Van Solingen-Ristea, Rodica, van Eygen, Veerle, Crauwels, Herta, Ford, Susan, Talarico, Christine, Benn, Paul, Wang, Yuanyuan, Hudson, Krischan J, Chounta, Vasiliki, Cutrell, Amy, Patel, Parul, Shaefer, Mark, Margolis, David A, Smith, Kimberly Y, Vanveggel, Simon, Spreen, William

“…Phase 3 clinical studies showed non-inferiority of long-acting intramuscular cabotegravir and rilpivirine dosed every 4 weeks to oral antiretroviral therapy…”
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Extracellular matrix density regulates the rate of neovessel growth and branching in sprouting angiogenesis by Edgar, Lowell T, Underwood, Clayton J, Guilkey, James E, Hoying, James B, Weiss, Jeffrey A

“…Angiogenesis is regulated by the local microenvironment, including the mechanical interactions between neovessel sprouts and the extracellular matrix (ECM)…”
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Zinc Inhibits TRPV1 to Alleviate Chemotherapy-Induced Neuropathic Pain by Luo, Jialie, Bavencoffe, Alexis, Yang, Pu, Feng, Jing, Yin, Shijin, Qian, Aihua, Yu, Weihua, Liu, Shenbin, Gong, Xuan, Cai, Tao, Walters, Edgar T, Dessauer, Carmen W, Hu, Hongzhen

“…Zinc is a transition metal that has a long history of use as an anti-inflammatory agent. It also soothes pain sensations in a number of animal models. However,…”
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Brief Report: The Right People, Right Places, and Right Practices: Disparities in PrEP Access Among African American Men, Women, and MSM in the Deep South by Elopre, Latesha, Kudroff, Kachina, Westfall, Andrew O, Overton, Edgar T, Mugavero, Michael J

“…Disproportionate rates of HIV are observed in Black women and men, especially in the Southern United States. We observed limited uptake of preexposure…”
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Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability by Laumet, Geoffroy, Bavencoffe, Alexis, Edralin, Jules D., Huo, Xiao-Jiao, Walters, Edgar T., Dantzer, Robert, Heijnen, Cobi J., Kavelaars, Annemieke

“…Understanding the mechanisms that drive transition from acute to chronic pain is essential to identify new therapeutic targets. The importance of endogenous…”
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Strong inferences about pain in invertebrates require stronger evidence by Walters, Edgar T

“…Evidence for sentience in animals distantly related to humans is often sought in observations of behavioral and neural responses to noxious stimuli that would…”
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Pitavastatin to Prevent Cardiovascular Disease in HIV Infection by Grinspoon, Steven K., Fitch, Kathleen V., Zanni, Markella V., Fichtenbaum, Carl J., Umbleja, Triin, Aberg, Judith A., Overton, Edgar T., Malvestutto, Carlos D., Bloomfield, Gerald S., Currier, Judith S., Martinez, Esteban, Roa, Jhoanna C., Diggs, Marissa R., Fulda, Evelynne S., Paradis, Kayla, Wiviott, Stephen D., Foldyna, Borek, Looby, Sara E., Desvigne-Nickens, Patrice, Alston-Smith, Beverly, Leon-Cruz, Jorge, McCallum, Sara, Hoffmann, Udo, Lu, Michael T., Ribaudo, Heather J., Douglas, Pamela S.

“…In a trial involving participants with HIV infection receiving antiretroviral therapy, the use of pitavastatin resulted in a lower risk of a major adverse…”
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Depolarization-Dependent C-Raf Signaling Promotes Hyperexcitability and Reduces Opioid Sensitivity of Isolated Nociceptors after Spinal Cord Injury by Garza Carbajal, Anibal, Bavencoffe, Alexis, Walters, Edgar T, Dessauer, Carmen W

“…Chronic pain caused by spinal cord injury (SCI) is notoriously resistant to treatment, particularly by opioids. After SCI, DRG neurons show hyperactivity and…”
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