Search Results - "Edgar, Dale M."

Decoupling of Sleep-Dependent Cortical and Hippocampal Interactions in a Neurodevelopmental Model of Schizophrenia by Phillips, Keith G., Bartsch, Ullrich, McCarthy, Andrew P., Edgar, Dale M., Tricklebank, Mark D., Wafford, Keith A., Jones, Matt W.

“…Rhythmic neural network activity patterns are defining features of sleep, but interdependencies between limbic and cortical oscillations at different…”
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Hibernation in Black Bears: Independence of Metabolic Suppression from Body Temperature by Tøien, Øivind, Blake, John, Edgar, Dale M, Grahn, Dennis A, Heller, H. Craig, Barnes, Brian M

“…Black bears hibernate for 5 to 7 months a year and, during this time, do not eat, drink, urinate, or defecate. We measured metabolic rate and body temperature…”
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REM sleep homeostasis in the absence of REM sleep: Effects of antidepressants by McCarthy, Andrew, Wafford, Keith, Shanks, Elaine, Ligocki, Marcin, Edgar, Dale M., Dijk, Derk-Jan

“…Most antidepressants suppress rapid eye movement (REM) sleep, which is thought to be important to brain function, yet the resulting REM sleep restriction is…”
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Lesions of the suprachiasmatic nucleus eliminate the daily rhythm of Hypocretin-1 release by SHENGWEN ZHANG, ZEITZER, Jamie M, YOSHIDA, Yasushi, WISOR, Jonathan P, NISHINO, Seiji, EDGAR, Dale M, MIGNOT, Emmanuel

“…Hypocretins (orexins) are involved in the sleep disorder narcolepsy. While hypocretin-1 has a daily oscillation, little is known regarding the relative…”
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A role for cryptochromes in sleep regulation by Wisor, Jonathan P, O'Hara, Bruce F, Terao, Akira, Selby, Chris P, Kilduff, Thomas S, Sancar, Aziz, Edgar, Dale M, Franken, Paul

“…The cryptochrome 1 and 2 genes (cry1 and cry2) are necessary for the generation of circadian rhythms, as mice lacking both of these genes (cry1,2-/-) lack…”
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Circadian and Homeostatic Control of Rapid Eye Movement (REM) Sleep: Promotion of REM Tendency by the Suprachiasmatic Nucleus by Wurts, Sarah W, Edgar, Dale M

“…The daily timing of rapid eye movement (REM) sleep reflects an interaction between the circadian pacemaker located in the suprachiasmatic nucleus of the…”
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Distinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617 by Loomis, Sally, McCarthy, Andrew, Baxter, Christopher, Kellett, Daniel O., Edgar, Dale M., Tricklebank, Mark, Gilmour, Gary

“…While treatment options are available, excessive daytime sleepiness (EDS) remains a significant unmet medical need for many patients. Relatively little rodent…”
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Dopaminergic Role in Stimulant-Induced Wakefulness by Wisor, Jonathan P, Nishino, Seiji, Sora, Ichiro, Uhl, George H, Mignot, Emmanuel, Edgar, Dale M

“…The role of dopamine in sleep regulation and in mediating the effects of wake-promoting therapeutics is controversial. In this study, polygraphic recordings…”
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In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat by Gilmour, Gary, Broad, Lisa M., Wafford, Keith A., Britton, Thomas, Colvin, Ellen M., Fivush, Adam, Gastambide, Francois, Getman, Brian, Heinz, Beverly A., McCarthy, Andrew P., Prieto, Lourdes, Shanks, Elaine, Smith, Janice W., Taboada, Lorena, Edgar, Dale M., Tricklebank, Mark D.

“…The demonstrated functional interaction of metabotropic glutamate 5 (mGlu5) receptors with N-methyl-d-aspartate (NMDA) receptors has prompted speculation that…”
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Serotonin and the mammalian circadian system: I. In vitro phase shifts by serotonergic agonists and antagonists by Prosser, R A, Dean, R R, Edgar, D M, Heller, H C, Miller, J D

“…The primary mammalian circadian clock, located in the suprachiasmatic nuclei (SCN), receives a major input from the raphe nuclei. The role of this input is…”
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Serotonin-containing fibers in the suprachiasmatic hypothalamus attenuate light-induced phase delays in mice by Bradbury, Margaret J, Dement, William C, Edgar, Dale M

“…Photic and non-photic stimuli phase shift and entrain circadian rhythms through distinct but interacting mechanisms which impinge on the suprachiasmatic…”
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Biological rhythmicity in preterm infants prior to discharge from neonatal intensive care by GLOTZBACH, S. F, EDGAR, D. M, ARIAGNO, R. L

“…The study of biological rhythms and the influence of environmental factors in the timing and synchronization of different rhythmic events have important…”
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Activity feedback to the mammalian circadian pacemaker: influence on observed measures of rhythm period length by Edgar, D M, Martin, C E, Dement, W C

“…In the mouse, activity is precisely timed by the circadian clock and is normally most intense in the early subjective night. Since vigorous activity (e.g.,…”
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Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat by Edgar, D M, Seidel, W F

“…Modafinil, a novel compound for treating excessive sleepiness, potently increases wakefulness in laboratory rodents, cats, monkeys and humans. Although its…”
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A Nonphotic Stimulus Inverts the Diurnal-Nocturnal Phase Preference in Octodon degus by Kas, Martien J. H, Edgar, Dale M

“…Mechanisms differentiating diurnal from nocturnal species are thought to be innate components of the circadian timekeeping system and may be located downstream…”
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Sleep-promoting effects of melatonin: At what dose, in whom, under what conditions, and by what mechanisms? by SACK, R. L, HUGHES, R. J, EDGAR, D. M, LEWY, A. J

“…Differing conclusions regarding the sleep-promoting effects of melatonin may be the result of the broad range of doses employed (0.1-2000 mg), the differing…”
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Sleep states and sleep electroencephalographic spectral power in mice lacking the β3 subunit of the GABAA receptor by WISOR, Jonathan P, DELOREY, Timothy M, HOMANICS, Gregg E, EDGAR, Dale M

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A novel quantitative trait locus on mouse chromosome 18, era1, modifies the entrainment of circadian rhythms by WISOR, Jonathan P, STRIZ, Martin, DEVOSS, Jason, MURPHY, Greer M, EDGAR, Dale M, O'HARA, Bruce F

“…The mammalian circadian clock in the suprachiasmatic nuclei (SCN) of the hypothalamus conveys 24-h rhythmicity to sleep-wake cycles, locomotor activity, and…”
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Systematic 24-hr Behavioral Observations of Sleep and Wakefulness in a Skilled-Care Nursing Facility by Bliwise, Donald L, Bevier, Wendy C, Bliwise, Nancy G, Edgar, Dale M, Dement, William C

“…Sleep patterns of aged, infirm, demented, chronically institutionalized residents of a skilled-care nursing facility were studied. The purpose of this…”
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Effects of adrenalectomy and subsequent corticosterone replacement on rat sleep state and EEG power spectra by Bradbury, M J, Dement, W C, Edgar, D M

“…Individual effects of corticotropin-releasing hormone (CRH) and glucocorticoids on sleep have been difficult to discern due to the feedback effects each…”
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