Search Results - "Edgar, DM"

Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation by Edgar, DM, Dement, WC, Fuller, CA

“…Sleep and wakefulness are governed by both the suprachiasmatic nuclei of the hypothalamus (SCN), and a sleep homeostatic process; however, the interaction of…”
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Dopaminergic Role in Stimulant-Induced Wakefulness by Wisor, Jonathan P, Nishino, Seiji, Sora, Ichiro, Uhl, George H, Mignot, Emmanuel, Edgar, Dale M

“…The role of dopamine in sleep regulation and in mediating the effects of wake-promoting therapeutics is controversial. In this study, polygraphic recordings…”
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Gene expression in the rat brain during sleep deprivation and recovery sleep: an Affymetrix GeneChip® study by Terao, A., Wisor, J.P., Peyron, C., Apte-Deshpande, A., Wurts, S.W., Edgar, D.M., Kilduff, T.S.

“…Previous studies have demonstrated that macromolecular synthesis in the brain is modulated in association with the occurrence of sleep and wakefulness…”
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Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer’s disease: A role for cholinergic transmission by Wisor, J.P., Edgar, D.M., Yesavage, J., Ryan, H.S., McCormick, C.M., Lapustea, N., Murphy, G.M.

“…The Tg2576 mouse model of Alzheimer’s disease (AD) exhibits age-dependent amyloid β (Aβ) deposition in the brain. We studied electroencephalographically…”
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Lesions of the suprachiasmatic nucleus eliminate the daily rhythm of Hypocretin-1 release by SHENGWEN ZHANG, ZEITZER, Jamie M, YOSHIDA, Yasushi, WISOR, Jonathan P, NISHINO, Seiji, EDGAR, Dale M, MIGNOT, Emmanuel

“…Hypocretins (orexins) are involved in the sleep disorder narcolepsy. While hypocretin-1 has a daily oscillation, little is known regarding the relative…”
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Circadian and Homeostatic Control of Rapid Eye Movement (REM) Sleep: Promotion of REM Tendency by the Suprachiasmatic Nucleus by Wurts, Sarah W, Edgar, Dale M

“…The daily timing of rapid eye movement (REM) sleep reflects an interaction between the circadian pacemaker located in the suprachiasmatic nucleus of the…”
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Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat by Edgar, D M, Seidel, W F

“…Modafinil, a novel compound for treating excessive sleepiness, potently increases wakefulness in laboratory rodents, cats, monkeys and humans. Although its…”
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A Nonphotic Stimulus Inverts the Diurnal-Nocturnal Phase Preference in Octodon degus by Kas, Martien J. H, Edgar, Dale M

“…Mechanisms differentiating diurnal from nocturnal species are thought to be innate components of the circadian timekeeping system and may be located downstream…”
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Sleep-promoting effects of melatonin: At what dose, in whom, under what conditions, and by what mechanisms? by SACK, R. L, HUGHES, R. J, EDGAR, D. M, LEWY, A. J

“…Differing conclusions regarding the sleep-promoting effects of melatonin may be the result of the broad range of doses employed (0.1-2000 mg), the differing…”
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Sleep states and sleep electroencephalographic spectral power in mice lacking the β 3 subunit of the GABA A receptor by Wisor, Jonathan P, DeLorey, Timothy M, Homanics, Gregg E, Edgar, Dale M

“…Mice lacking the GABA A receptor β 3 subunit exhibit a profound disruption in thalamic circuitry. We have studied sleep in these mice under baseline conditions…”
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Altered rapid eye movement sleep timing in serotonin transporter knockout mice by Wisor, J. P, Wurts, S. W, Hall, F. S, Lesch, K. P, Murphy, D. L, Uhl, G. R, Edgar, D. M

“…The monoamine neurotransmitter serotonin has long been implicated in development and maintenance of sleep patterns, yet the role of the serotonin transporter…”
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Effects of adrenalectomy and subsequent corticosterone replacement on rat sleep state and EEG power spectra by Bradbury, M J, Dement, W C, Edgar, D M

“…Individual effects of corticotropin-releasing hormone (CRH) and glucocorticoids on sleep have been difficult to discern due to the feedback effects each…”
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Serotonergic afferents mediate activity-dependent entrainment of the mouse circadian clock by Edgar, D M, Reid, M S, Dement, W C

“…The circadian pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus receives serotonergic afferents from the midbrain raphe nuclei, but the…”
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Photic phase response curve in Octodon degus: assessment as a function of activity phase preference by Kas, M J, Edgar, D M

“…Light exposure during the early and late subjective night generally phase delays and advances circadian rhythms, respectively. However, this generality was…”
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Regularly scheduled voluntary exercise synchronizes the mouse circadian clock by Edgar, D M, Dement, W C

“…Circadian rhythm entrainment has long been thought to depend exclusively on periodic cues in the external environment. However, evidence now suggests that…”
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Prepro-hypocretin (prepro-orexin) expression is unaffected by short-term sleep deprivation in rats and mice by TERAO, Akira, PEYRON, Christelle, DING, Jane, WURTS, Sarah W, EDGAR, Dale M, HELLER, H. Craig, KILDUFF, Thomas S

“…The hypocretin/orexin ligand-receptor system has recently been implicated in the sleep disorder narcolepsy. During the dark (active) period, null mutants of…”
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A possible glial role in the mammalian circadian clock by Prosser, R A, Edgar, D M, Heller, H C, Miller, J D

“…The primary mammalian circadian clock is located within the suprachiasmatic nuclei (SCN), but the cellular organization of the clock is not yet known. We…”
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Serotonin-containing fibers in the suprachiasmatic hypothalamus attenuate light-induced phase delays in mice by Bradbury, Margaret J, Dement, William C, Edgar, Dale M

“…Photic and non-photic stimuli phase shift and entrain circadian rhythms through distinct but interacting mechanisms which impinge on the suprachiasmatic…”
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Scheduled Voluntary Wheel Running Activity Modulates Free-Running Circadian Body Temperature Rhythms in Octodon degus by Kas, Martien J. H., Edgar, Dale M.

“…Entrainment of the circadian pacemaker to nonphotic stimuli, such as scheduled wheel-running activity, is well characterized in nocturnal rodents, but little…”
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Circadian timed wakefulness at dawn opposes compensatory sleep responses after sleep deprivation in Octodon degus by KAS, M. J. H, EDGAR, D. M

“…The circadian timing system in mammals is thought to promote wakefulness and oppose sleep drive that accumulates across the activity phase in diurnal and…”
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