Search Results - "Edgar, Alexander J."

Structural and Functional Basis for p38-MK2-Activated Rsk Signaling in Toll-Like Receptor-Stimulated Dendritic Cells by Zaru, Rossana, Edgar, Alexander J., Hanauer, André, Watts, Colin

“…Rsk kinases play important roles in several cellular processes such as proliferation, metabolism, and migration. Until recently, Rsk activation was thought to…”
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The PDK1-Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning by Zaru, Rossana, Matthews, Stephen P, Edgar, Alexander J, Prescott, Alan R, Gomez-Nicola, Diego, Hanauer, André, Watts, Colin

“…Langerhans cells (LC), the dendritic cells of the epidermis, are distributed in a distinctive regularly spaced array. In the mouse, the LC array is established…”
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A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870 by Edgar, Alexander J, Trost, Matthias, Watts, Colin, Zaru, Rossana

“…Protein kinase inhibitors frequently have interesting effects that cannot be fully ascribed to the intended target kinase(s) but identifying additional targets…”
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A crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells by Gawden-Bone, Christian, West, Michele A, Morrison, Vicky L, Edgar, Alexander J, McMillan, Sarah J, Dill, Brian D, Trost, Matthias, Prescott, Alan, Fagerholm, Susanna C, Watts, Colin

“…The dynamic properties of podosomes, their ability to degrade the underlying matrix and their modulation by Toll-like receptor (TLR) signaling in dendritic…”
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A critical role for beta2 integrins in podosome formation, dynamics and TLR-signaled disassembly in dendritic cells by Gawden-Bone, Christian, West, Michele A., Morrison, Vicky L., Edgar, Alexander J., McMillan, Sarah J., Dill, Brian D., Trost, Matthias, Prescott, Alan, Fagerholm, Susanna C., Watts, Colin

“…The dynamic properties of podosomes, their ability to degrade the underlying matrix and their modulation by TLR-signalling in dendritic cells (DC) suggests…”
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A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870 by Edgar, Alexander J, Trost, Matthias, Watts, Colin, Zaru, Rossana

“…Protein kinase inhibitors frequently have interesting effects that cannot be fully ascribed to the intended target kinase(s) but identifying additional targets…”
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Analysis of Three Deletion Breakpoints in Xp21.1 and the Further Localization of RP3 by Brown, John, Dry, Katherine L., Edgar, Alexander J., Pryde, Fiona E., Hardwick, Lee J., Aldred, Micheala A., Lester, Douglas H., Boyle, Shelagh, Kaplan, Josseline, Dufier, Jean-Louis, Ho, Meng-Fatt, Monaco, Anthony M., Musarella, Maria A., Wright, Alan F.

“…The gene responsible for X-linked retinitis pigmentosa (xlRP) in Xp21.1 (RP3) was initially localized by deletion analysis to within a 150- to 170-kb region…”
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