Search Results - "Ederveen, Agnes L. Hipgrave"
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Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination
Published in Nature communications (05-10-2021)“…Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate receptor- and tissue-specific sequestration of infected erythrocytes (IEs)…”
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2
Simultaneous Immunoglobulin A and G Glycopeptide Profiling for High-Throughput Applications
Published in Analytical chemistry (Washington) (17-03-2020)“…Immunoglobulin (Ig) glycosylation is recognized for its influence on Ig turnover and effector functions. However, the large-scale profiling of Ig glycosylation…”
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3
Dissecting Total Plasma and Protein-Specific Glycosylation Profiles in Congenital Disorders of Glycosylation
Published in International journal of molecular sciences (15-10-2020)“…Protein -glycosylation is a multifactorial process involved in many biological processes. A broad range of congenital disorders of glycosylation (CDGs) have…”
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4
Biophysical analysis of sialic acid recognition by the complement regulator Factor H
Published in Glycobiology (Oxford) (01-10-2018)“…Complement factor H (FH), an elongated and substantially glycosylated 20-domain protein, is a soluble regulator of the complement alternative pathway (AP). It…”
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Antigen specificity determines anti‐red blood cell IgG‐Fc alloantibody glycosylation and thereby severity of haemolytic disease of the fetus and newborn
Published in British journal of haematology (01-02-2017)“…Summary Haemolytic disease of the fetus and newborn (HDFN) is a severe disease in which fetal red blood cells (RBC) are destroyed by maternal anti‐RBC IgG…”
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6
Fish-hunting cone snail disrupts prey’s glucose homeostasis with weaponized mimetics of somatostatin and insulin
Published in Nature communications (20-08-2024)“…Venomous animals have evolved diverse molecular mechanisms to incapacitate prey and defend against predators. Most venom components disrupt nervous, locomotor,…”
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The N- Glycosylation of Mouse Immunoglobulin G (IgG)-Fragment Crystallizable Differs Between IgG Subclasses and Strains
Published in Frontiers in immunology (31-05-2017)“…-linked glycosylation of the fragment crystallizable (Fc)-region of immunoglobulin G (IgG) is known to have a large influence on the activity of the antibody,…”
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Effluent and serum protein N-glycosylation is associated with inflammation and peritoneal membrane transport characteristics in peritoneal dialysis patients
Published in Scientific reports (17-01-2018)“…Mass spectrometric glycomics was used as an innovative approach to identify biomarkers in serum and dialysate samples from peritoneal dialysis (PD) patients…”
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9
Ethyl Esterification for MALDI-MS Analysis of Protein Glycosylation
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2016)“…Ethyl esterification is a technique for the chemical modification of sialylated glycans, leading to enhanced stability when performing matrix-assisted laser…”
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10
Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin
Published in Journal of structural biology (01-08-2016)“…Autotaxin (ATX) is a secreted phosphodiesterase that produces the signalling lipid lysophosphatidic acid (LPA). The bimetallic active site of ATX is…”
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11
The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients
Published in Frontiers in immunology (11-06-2019)“…Autoantibodies to myelin oligodendrocytes glycoprotein (MOG) are found in a fraction of patients with inflammatory demyelination and are detected with…”
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12
LaCyTools: A Targeted Liquid Chromatography–Mass Spectrometry Data Processing Package for Relative Quantitation of Glycopeptides
Published in Journal of proteome research (01-07-2016)“…Bottom-up glycoproteomics by liquid chromatography–mass spectrometry (LC–MS) is an established approach for assessing glycosylation in a protein- and…”
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13
MassyTools: A High-Throughput Targeted Data Processing Tool for Relative Quantitation and Quality Control Developed for Glycomic and Glycoproteomic MALDI-MS
Published in Journal of proteome research (04-12-2015)“…The study of N-linked glycosylation has long been complicated by a lack of bioinformatics tools. In particular, there is still a lack of fast and robust data…”
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14
Plasma protein N-glycan signatures of type 2 diabetes
Published in Biochimica et biophysica acta. General subjects (01-12-2018)“…Little is known about enzymatic N-glycosylation in type 2 diabetes, a common posttranslational modification of proteins influencing their function and…”
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ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab
Published in Oncogene (27-05-2021)“…The clinical performance of the therapeutic monoclonal antibody trastuzumab in the treatment of ErbB2-positive unresectable gastric cancer (GC) is severely…”
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16
Comprehensive characterization of bacterial glycoconjugate vaccines by liquid chromatography - mass spectrometry
Published in Carbohydrate polymers (01-10-2024)“…Bacterial pathogens can cause a broad range of infections with detrimental effects on health. Vaccine development is essential as multi-drug resistance in…”
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Automation of High-Throughput Mass Spectrometry-Based Plasma N‑Glycome Analysis with Linkage-Specific Sialic Acid Esterification
Published in Journal of proteome research (04-09-2015)“…Glycosylation is a post-translational modification of key importance with heterogeneous structural characteristics. Previously, we have developed a robust,…”
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Murine Plasma N‑Glycosylation Traits Associated with Sex and Strain
Published in Journal of proteome research (07-10-2016)“…Glycosylation is an abundant and important protein modification with large influence on the properties and interactions of glycoconjugates. Human plasma…”
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Assessment of IgG-Fc glycosylation from individual RhD-specific B cell clones reveals regulation at clonal rather than clonotypic level
Published in Immunology (01-03-2024)“…The type and strength of effector functions mediated by immunoglobulin G (IgG) antibodies rely on the subclass and the composition of the N297 glycan…”
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Site-specific N- and O-glycosylation analysis of atacicept
Published in mAbs (18-08-2019)“…The Fc-fusion protein atacicept is currently under clinical investigation for its biotherapeutic application in autoimmune diseases owing to its ability to…”
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