Exploring the muscle architecture effect on the mechanical behaviour of mouse rotator cuff muscles

Incorporating detailed muscle architecture aspects into computational models can enable researchers to gain deeper insights into the complexity of muscle function, movement, and performance. In this study, we employed histological, multiphoton image processing, and finite element method techniques t...

Full description

Saved in:

Bibliographic Details
Published in:	Computers in biology and medicine Vol. 174; p. 108401
Main Authors:	Heras-Sádaba, A., Pérez-Ruiz, A., Martins, P., Ederra, C., de Solórzano, C. Ortiz, Abizanda, G., Pons-Villanueva, J., Calvo, B., Grasa, J.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 01-05-2024 Elsevier Limited
Subjects:	Animals Architecture Biology Biomechanical Phenomena - physiology Collagen Collagen - chemistry Collagen - metabolism Engineering research Fiber orientation Finite Element Analysis Finite element method Image processing Infraspinatus Injuries Male Mathematical models Mechanical properties Mechanical tests Mice Mice, Inbred C57BL Models, Biological Mouse rotator cuff Muscle architecture Muscles Physiology Rotator cuff Rotator Cuff - anatomy & histology Rotator Cuff - physiology Supraspinatus Three dimensional models Finite element method Muscle architecture Mouse rotator cuff Supraspinatus Infraspinatus
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Incorporating detailed muscle architecture aspects into computational models can enable researchers to gain deeper insights into the complexity of muscle function, movement, and performance. In this study, we employed histological, multiphoton image processing, and finite element method techniques to characterise the mechanical dependency on the architectural behaviour of supraspinatus and infraspinatus mouse muscles. While mechanical tests revealed a stiffer passive behaviour in the supraspinatus muscle, the collagen content was found to be two times higher in the infraspinatus. This effect was unveiled by analysing the alignment of fibres during muscle stretch with the 3D models and the parameters obtained in the fitting. Therefore, a strong dependence of muscle behaviour, both active and passive, was found on fibre orientation rather than collagen content. [Display omitted] •Infraspinatus showed larger collagen content, pennation and tetany than supraspinatus•Multiphoton microscopy allowed to track fibre orientation and develop accurate models•3D FE models unveiled the architecture effect on both passive and active responses
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0010-4825 1879-0534
DOI:	10.1016/j.compbiomed.2024.108401