Search Results - "Eder, P S"

Using biodosimetry to enhance the public health response to a nuclear incident by Wathen, L. K., Eder, P. S., Horwith, G., Wallace, R. L.

“…Radiation Biodosimetry is a continually developing clinical diagnostic field, which focuses on biological markers that proportionally change in relationship to…”
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RNA as a drug target: methods for biophysical characterization and screening by Xavier, K.Asish, Eder, Paul S, Giordano, Tony

“…RNA folds into complex structures that can interact specifically with effector proteins. These interactions are essential for various biological functions. In…”
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Ribonuclease H from K562 human erythroleukemia cells. Purification, characterization, and substrate specificity by Eder, P S, Walder, J A

“…The major ribonuclease H from K562 human erythroleukemia cells has been purified more than 4,000-fold. This RNase H, now termed RNase H1, is an…”
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Substrate specificity of human RNase H1 and its role in excision repair of ribose residues misincorporated in DNA by Eder, P S, Walder, R Y, Walder, J A

“…Recently we have shown that the major isoform of RNase H in human cells, RNase H1, is able to cleave DNA substrates containing a single RNA-DNA base pair, an…”
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An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript by Rogers, Jack T, Randall, Jeffrey D, Cahill, Catherine M, Eder, Paul S, Huang, Xudong, Gunshin, Hiromi, Leiter, Lorene, McPhee, Jay, Sarang, Satinder S, Utsuki, Tada, Greig, Nigel H, Lahiri, Debomoy K, Tanzi, Rudolph E, Bush, Ashley I, Giordano, Tony, Gullans, Steve R

“…Iron-responsive elements (IREs) are the RNA stem loops that control cellular iron homeostasis by regulating ferritin translation and transferrin receptor mRNA…”
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Kinetics of Coupling Reactions That Generate Monothiophosphate Disulfides:  Implications for Modification of RNAs by Wu, Chung-Wen, Eder, Paul S, Gopalan, Venkat, Behrman, Edward J

“…The inclusion of guanosine-5‘-monothiophosphate (GMPS) in an in vitro transcription reaction facilitates enzymatic synthesis of an RNA transcript with a…”
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The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein by Michael, W.Matthew, Eder, Paul S., Dreyfuss, Gideon

“…Protein import into the nucleus and export from the nucleus are signal‐mediated processes that require energy. The nuclear transport process about which the…”
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Transportin-Mediated Nuclear Import of Heterogeneous Nuclear RNP Proteins by Siomi, Mikiko C., Eder, Paul S., Kataoka, Naoyuki, Wan, Lili, Liu, Qing, Dreyfuss, Gideon

“…Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an abundant nuclear protein that plays an important role in pre-mRNA processing and mRNA export from the…”
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Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P by GUERRIER-TAKADA, CECILIA, EDER, PAUL S., GOPALAN, VENKAT, ALTMAN, SIDNEY

“…In HeLa cells, ribonuclease P (RNase P), the tRNA processing enzyme consists of an RNA subunit (H1 RNA) associated with at least nine protein subunits, Rpp14,…”
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The 35-Nucleotide Spliced Leader Sequence is Common to All Trypanosome Messenger RNA's by Walder, Joseph A., Eder, Paul S., Engman, David M., Brentano, Steven T., Walder, Roxanne Y., Knutzon, Deborah S., Dorfman, David M., Donelson, John E.

“…In Trypanosomatidae the messenger RNA's (mRNA's) that code for the variant surface glycoproteins (VSG's), tubulins, calmodulin, and at least a subset of other…”
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Phosphorylation reduces the affinity of protein 4.1 for spectrin by Eder, Paul S, Soong, Chu Jing, Tao, Mariano

“…The phosphorylation of protein 4.1 by the membrane kinase and casein kinase A has been investigated. Each of these kinases catalyzed the incorporation of 2 mol…”
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Characterization of Two Scleroderma Autoimmune Antigens that Copurify with Human Ribonuclease P by Eder, Paul S., Kekuda, Ramesh, Stolc, Viktor, Altman, Sidney

“…Human RNase P has been purified more than 2000-fold from HeLa cells. In addition to the RNA component, H1 RNA, polypeptides of molecular masses 14,20,25,30,38,…”
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Rpp14 and Rpp29, two protein subunits of human ribonuclease P by JARROUS, NAYEF, EDER, PAUL S., WESOLOWSKI, DONNA, ALTMAN, SIDNEY

“…In HeLa cells, the tRNA processing enzyme ribonuclease P (RNase P) consists of an RNA molecule associated with at least eight protein subunits, hPop1, Rpp14,…”
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Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P by JARROUS, NAYEF, EDER, PAUL S., GUERRIER-TAKADA, CECILIA, HOOG, CHRISTER, ALTMAN, SIDNEY

“…At least six proteins co-purify with human ribonuclease P (RNase P), a tRNA processing ribonucleoprotein. Two of these proteins, Rpp30 and Rpp38, are Th…”
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Alzheimer’s disease drug discovery targeted to the APP mRNA 5′Untranslated region by Rogers, Jack T., Randall, Jeffrey D., Eder, Paul S., Huang, Xudong, Bush, Ashley I., Tanzi, Rudolph E., Venti, Amanda, Payton, Sandra M., Giordano, Tony, Nagano, Seiichi, Cahill, Catherine M., Moir, Robert, Lahiri, Debomoy K., Greig, Nigel, Sarang, Satinder Singh, Gullans, Steven R.

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A surrogate-based approach for post-genomic partner identification by Pillutla, R C, Hsiao, K, Brissette, R, Eder, P S, Giordano, T, Fletcher, P W, Lennick, M, Blume, A J, Goldstein, N I

“…Modern drug discovery is concerned with identification and validation of novel protein targets from among the 30,000 genes or more postulated to be present in…”
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The RNA Subunit of Ribonuclease P from the Zebrafish, Danio rerio by Eder, P S, Srinivasan, A, Fishman, M C, Altman, S

“…A simple strategy has been devised to identify the gene encoding the RNA subunit of RNase P from the zebrafish, Danio rerio . The sequence obtained by…”
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The next-generation Hybrid Capture® High-Risk HPV DNA assay on a fully automated platform by Eder, Paul S, Lou, Jianrong, Huff, John, Macioszek, Jerzy

“…ABSTRACT Background A next-generation diagnostic system has been developed at QIAGEN. The QIAensemble™ system consists of an analytical subsystem (JE2000™)…”
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Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region by Rogers, Jack T, Randall, Jeffrey D, Eder, Paul S, Huang, Xudong, Bush, Ashley I, Tanzi, Rudolph E, Venti, Amanda, Payton, Sandra M, Giordano, Tony, Nagano, Seiichi, Cahill, Catherine M, Moir, Robert, Lahiri, Debomoy K, Greig, Nigel, Sarang, Satinder Singh, Gullans, Steven R

“…We performed a screen for drugs that specifically interact with the 5' untranslated region of the mRNA coding for the Alzheimer's Amyloid Precursor Protein…”
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Substrate specificity and kinetics of degradation of antisense oligonucleotides by a 3' exonuclease in plasma by Eder, P S, DeVine, R J, Dagle, J M, Walder, J A

“…The pathways of degradation of oligodeoxynucleotides in plasma from several mammalian species, including human, were investigated. In all cases, hydrolysis…”
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