Search Results - "Eden, Patrik"

Establishing strong imputation performance of a denoising autoencoder in a wide range of missing data problems by Abiri, Najmeh, Linse, Björn, Edén, Patrik, Ohlsson, Mattias

“…Dealing with missing data in data analysis is inevitable. Although powerful imputation methods that address this problem exist, there is still much room for…”
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Artificial neural network models to predict nodal status in clinically node-negative breast cancer by Dihge, Looket, Ohlsson, Mattias, Edén, Patrik, Bendahl, Pär-Ola, Rydén, Lisa

“…Sentinel lymph node biopsy (SLNB) is standard staging procedure for nodal status in breast cancer, but lacks therapeutic benefit for patients with benign…”
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Finding Risk Groups by Optimizing Artificial Neural Networks on the Area under the Survival Curve Using Genetic Algorithms by Kalderstam, Jonas, Edén, Patrik, Ohlsson, Mattias

“…We investigate a new method to place patients into risk groups in censored survival data. Properties such as median survival time, and end survival rate, are…”
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Transcriptional regulation of lineage commitment--a stochastic model of cell fate decisions by Teles, Jose, Pina, Cristina, Edén, Patrik, Ohlsson, Mattias, Enver, Tariq, Peterson, Carsten

“…Molecular mechanisms employed by individual multipotent cells at the point of lineage commitment remain largely uncharacterized. Current paradigms span from…”
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A multicenter study investigating the molecular fingerprint of psychological resilience in breast cancer patients: study protocol of the SCAN-B resilience study by Axelsson, Ulrika, Rydén, Lisa, Johnsson, Per, Edén, Patrik, Månsson, Johanna, Hallberg, Ingalill Rahm, Borrebaeck, Carl A K

“…Individual patients differ in their psychological response when receiving a cancer diagnosis, in this case breast cancer. Given the same disease burden, some…”
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Facilitating clinically relevant skin tumor diagnostics with spectroscopy-driven machine learning by Andersson, Emil, Hult, Jenny, Troein, Carl, Stridh, Magne, Sjögren, Benjamin, Pekar-Lukacs, Agnes, Hernandez-Palacios, Julio, Edén, Patrik, Persson, Bertil, Olariu, Victor, Malmsjö, Malin, Merdasa, Aboma

“…In the dawning era of artificial intelligence (AI), health care stands to undergo a significant transformation with the increasing digitalization of patient…”
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Comparing functional annotation analyses with Catmap by Breslin, Thomas, Edén, Patrik, Krogh, Morten

“…Ranked gene lists from microarray experiments are usually analysed by assigning significance to predefined gene categories, e.g., based on functional…”
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Gene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies by Andersson, Anna, Edén, Patrik, Olofsson, Tor, Fioretos, Thoas

“…Childhood leukemia is characterized by the presence of balanced chromosomal translocations or by other structural or numerical chromosomal changes. It is well…”
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Transcriptional Regulation of Lineage Commitment - A Stochastic Model of Cell Fate Decisions: e1003197 by Teles, Jose, Pina, Cristina, Edén, Patrik, Ohlsson, Mattias, Enver, Tariq, Peterson, Carsten

“…Molecular mechanisms employed by individual multipotent cells at the point of lineage commitment remain largely uncharacterized. Current paradigms span from…”
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A community effort to identify and correct mislabeled samples in proteogenomic studies by Yoo, Seungyeul, Shi, Zhiao, Wen, Bo, Kho, SoonJye, Pan, Renke, Feng, Hanying, Chen, Hong, Carlsson, Anders, Edén, Patrik, Ma, Weiping, Raymer, Michael, Maier, Ezekiel J., Tezak, Zivana, Johanson, Elaine, Hinton, Denise, Rodriguez, Henry, Zhu, Jun, Boja, Emily, Wang, Pei, Zhang, Bing

“…Sample mislabeling or misannotation has been a long-standing problem in scientific research, particularly prevalent in large-scale, multi-omic studies due to…”
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Training artificial neural networks directly on the concordance index for censored data using genetic algorithms by Kalderstam, Jonas, Edén, Patrik, Bendahl, Pär-Ola, Strand, Carina, Fernö, Mårten, Ohlsson, Mattias

“…Abstract Objective The concordance index (c-index) is the standard way of evaluating the performance of prognostic models in the presence of censored data…”
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Accounting for one-channel depletion improves missing value imputation in 2-dye microarray data by Ritz, Cecilia, Edén, Patrik

“…For 2-dye microarray platforms, some missing values may arise from an un-measurably low RNA expression in one channel only. Information of such "one-channel…”
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Gene expression profiling indicates that immunohistochemical expression of CD40 is a marker of an inflammatory reaction in the tumor stroma of diffuse large B-cell lymphoma by Rydström, Karin, Joost, Patrick, Ehinger, Mats, Edén, Patrik, Jerkeman, Mats, Cavallin-Ståhl, Eva, Linderoth, Johan

“…Abstract Immunohistochemical expression of CD40 is seen in 60-70% of diffuse large B-cell lymphoma (DLBCL) and is associated with a superior prognosis. By…”
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Pulsatile blood flow, shear force, energy dissipation and Murray's Law by Painter, Page R, Edén, Patrik, Bengtsson, Hans-Uno

“…Murray's Law states that, when a parent blood vessel branches into daughter vessels, the cube of the radius of the parent vessel is equal to the sum of the…”
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Identification of sentinel lymph node macrometastasis in breast cancer by deep learning based on clinicopathological characteristics by Zhang, Daqu, Svensson, Miriam, Edén, Patrik, Dihge, Looket

“…The axillary lymph node status remains an important prognostic factor in breast cancer, and nodal staging using sentinel lymph node biopsy (SLNB) is routine…”
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Genes associated with the tumour microenvironment are differentially expressed in cured versus primary chemotherapy‐refractory diffuse large B‐cell lymphoma by Linderoth, Johan, Edén, Patrik, Ehinger, Mats, Valcich, Jeanette, Jerkeman, Mats, Bendahl, Pär‐Ola, Berglund, Mattias, Enblad, Gunilla, Erlanson, Martin, Roos, Göran, Cavallin‐Ståhl, Eva

“…Summary In order to identify genes associated with primary chemotherapy‐resistance, gene expression profiles (GEP) in tumour tissue from 37 patients with de…”
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Identification and validation of single-sample breast cancer radiosensitivity gene expression predictors by Sjöström, Martin, Staaf, Johan, Edén, Patrik, Wärnberg, Fredrik, Bergh, Jonas, Malmström, Per, Fernö, Mårten, Niméus, Emma, Fredriksson, Irma

“…Adjuvant radiotherapy is the standard of care after breast-conserving surgery for primary breast cancer, despite a majority of patients being over- or…”
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Gene expression profilers and conventional clinical markers to predict distant recurrences for premenopausal breast cancer patients after adjuvant chemotherapy by Niméus-Malmström, Emma, Ritz, Cecilia, Edén, Patrik, Johnsson, Anders, Ohlsson, Mattias, Strand, Carina, Östberg, Görel, Fernö, Mårten, Peterson, Carsten

“…A large proportion of breast cancer patients are treated with adjuvant chemotherapy after the primary operation, but some will recur in spite of this…”
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Expression of P190 and P210 BCR/ABL1 in normal human CD34+ cells induces similar gene expression profiles and results in a STAT5 -dependent expansion of the erythroid lineage by Järås, Marcus, Johnels, Petra, Ågerstam, Helena, Lassen, Carin, Rissler, Marianne, Edén, Patrik, Cammenga, Jörg, Olofsson, Tor, Bjerrum, Ole Weis, Richter, Johan, Fan, Xiaolong, Fioretos, Thoas

“…Objective  The P190 and P210 BCR/ABL1 fusion genes are mainly associated with different types of hematologic malignancies, but it is presently unclear whether…”
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Single-Cell Network Analysis Identifies DDIT3 as a Nodal Lineage Regulator in Hematopoiesis by Pina, Cristina, Teles, José, Fugazza, Cristina, May, Gillian, Wang, Dapeng, Guo, Yanping, Soneji, Shamit, Brown, John, Edén, Patrik, Ohlsson, Mattias, Peterson, Carsten, Enver, Tariq

“…We explore cell heterogeneity during spontaneous and transcription-factor-driven commitment for network inference in hematopoiesis. Since individual genes…”
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