Search Results - "Eden, Martin"

A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms by Gao, Xiaoyi, Starmer, Joshua, Martin, Eden R.

“…Multiple testing is a challenging issue in genetic association studies using large numbers of single nucleotide polymorphism (SNP) markers, many of which…”
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Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer’s disease by Zhang, Lanyu, Silva, Tiago C., Young, Juan I., Gomez, Lissette, Schmidt, Michael A., Hamilton-Nelson, Kara L., Kunkle, Brian W., Chen, Xi, Martin, Eden R., Wang, Lily

“…DNA methylation differences in Alzheimer’s disease (AD) have been reported. Here, we conducted a meta-analysis of more than 1000 prefrontal cortex brain…”
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Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson's disease by Martins, Madalena, Rosa, Alexandra, Guedes, Leonor C, Fonseca, Benedita V, Gotovac, Kristina, Violante, Sara, Mestre, Tiago, Coelho, Miguel, Rosa, Mário M, Martin, Eden R, Vance, Jeffery M, Outeiro, Tiago F, Wang, Liyong, Borovecki, Fran, Ferreira, Joaquim J, Oliveira, Sofia A

“…miRNAs were recently implicated in the pathogenesis of numerous diseases, including neurological disorders such as Parkinson's disease (PD). miRNAs are…”
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Cross-tissue analysis of blood and brain epigenome-wide association studies in Alzheimer’s disease by C. Silva, Tiago, Young, Juan I., Zhang, Lanyu, Gomez, Lissette, Schmidt, Michael A., Varma, Achintya, Chen, X. Steven, Martin, Eden R., Wang, Lily

“…To better understand DNA methylation in Alzheimer’s disease (AD) from both mechanistic and biomarker perspectives, we performed an epigenome-wide meta-analysis…”
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MethReg: estimating the regulatory potential of DNA methylation in gene transcription by Silva, Tiago C, Young, Juan I, Martin, Eden R, Chen, X Steven, Wang, Lily

“…Epigenome-wide association studies often detect many differentially methylated sites, and many are located in distal regulatory regions. To further prioritize…”
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Explainable machine learning aggregates polygenic risk scores and electronic health records for Alzheimer’s disease prediction by Gao, Xiaoyi Raymond, Chiariglione, Marion, Qin, Ke, Nuytemans, Karen, Scharre, Douglas W., Li, Yi-Ju, Martin, Eden R.

“…Alzheimer’s disease (AD) is the most common late-onset neurodegenerative disorder. Identifying individuals at increased risk of developing AD is important for…”
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Genome-wide Association Study Implicates a Chromosome 12 Risk Locus for Late-Onset Alzheimer Disease by Beecham, Gary W., Martin, Eden R., Li, Yi-Ju, Slifer, Michael A., Gilbert, John R., Haines, Jonathan L., Pericak-Vance, Margaret A.

“…Only Apolipoprotein E polymorphisms have been consistently associated with the risk of late-onset Alzheimer disease (LOAD), but they represent only a minority…”
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Critical evaluation of the reliability of DNA methylation probes on the Illumina MethylationEPIC v1.0 BeadChip microarrays by Zhang, Wei, Young, Juan I, Gomez, Lissette, Schmidt, Michael A, Lukacsovich, David, Varma, Achintya, Chen, X Steven, Kunkle, Brian, Martin, Eden R, Wang, Lily

“…DNA methylation (DNAm) plays a crucial role in a number of complex diseases. However, the reliability of DNAm levels measured using Illumina arrays varies…”
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coMethDMR: accurate identification of co-methylated and differentially methylated regions in epigenome-wide association studies with continuous phenotypes by Gomez, Lissette, Odom, Gabriel J, Young, Juan I, Martin, Eden R, Liu, Lizhong, Chen, Xi, Griswold, Anthony J, Gao, Zhen, Zhang, Lanyu, Wang, Lily

“…Recent technology has made it possible to measure DNA methylation profiles in a cost-effective and comprehensive genome-wide manner using array-based…”
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Pesticide exposure and risk of Parkinson's disease: a family-based case-control study by Hancock, Dana B, Martin, Eden R, Mayhew, Gregory M, Stajich, Jeffrey M, Jewett, Rita, Stacy, Mark A, Scott, Burton L, Vance, Jeffery M, Scott, William K

“…Pesticides and correlated lifestyle factors (e.g., exposure to well-water and farming) are repeatedly reported risk factors for Parkinson's disease (PD), but…”
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Dry eye symptoms align more closely to non-ocular conditions than to tear film parameters by Galor, Anat, Felix, Elizabeth R, Feuer, William, Shalabi, Nabeel, Martin, Eden R, Margolis, Todd P, Sarantopoulos, Constantine D, Levitt, Roy C

“…To evaluate the relationship between dry eye symptoms, non-ocular conditions and tear film parameters. Cross-sectional study. The study population consisted of…”
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Incomplete response to artificial tears is associated with features of neuropathic ocular pain by Galor, Anat, Batawi, Hatim, Felix, Elizabeth R, Margolis, Todd P, Sarantopoulos, Konstantinos D, Martin, Eden R, Levitt, Roy C

“…Artificial tears are first-line therapy for patients with dry eye symptoms. It is not known, however, which patient factors associate with a positive response…”
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A pharmacist-led information technology intervention for medication errors (PINCER): a multicentre, cluster randomised, controlled trial and cost-effectiveness analysis by Avery, Anthony J, Prof, Rodgers, Sarah, PhD, Cantrill, Judith A, Prof, Armstrong, Sarah, PhD, Cresswell, Kathrin, PhD, Eden, Martin, MRes, Elliott, Rachel A, Prof, Howard, Rachel, PhD, Kendrick, Denise, Prof, Morris, Caroline J, PhD, Prescott, Robin J, Prof, Swanwick, Glen, Franklin, Matthew, MSc, Putman, Koen, PhD, Boyd, Matthew, PhD, Sheikh, Aziz, Prof

“…Summary Background Medication errors are common in primary care and are associated with considerable risk of patient harm. We tested whether a pharmacist-led,…”
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No Gene Is an Island: The Flip-Flop Phenomenon by Lin, Ping-I, Vance, Jeffery M., Pericak-Vance, Margaret A., Martin, Eden R.

“…An increasing number of publications are replicating a previously reported disease-marker association but with the risk allele reversed from the previous…”
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Genome‐Wide Association Study Confirms SNPs in SNCA and the MAPT Region as Common Risk Factors for Parkinson Disease by Edwards, Todd L., Scott, William K., Almonte, Cherylyn, Burt, Amber, Powell, Eric H., Beecham, Gary W., Wang, Liyong, Züchner, Stephan, Konidari, Ioanna, Wang, Gaofeng, Singer, Carlos, Nahab, Fatta, Scott, Burton, Stajich, Jeffrey M., Pericak‐Vance, Margaret, Haines, Jonathan, Vance, Jeffery M., Martin, Eden R.

“…Summary Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative prevalence of greater than one per thousand. To date three independent…”
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Identification of novel genes for age‐at‐onset of Alzheimer's disease by combining quantitative and survival trait analyses by Li, Yi‐Ju, Nuytemans, Karen, La, Jong ok, Jiang, Rong, Slifer, Susan H., Sun, Shuming, Naj, Adam, Gao, Xiaoyi Raymond, Martin, Eden R.

“…Introduction Our understanding of the genetic predisposition for age‐at‐onset (AAO) of Alzheimer's disease (AD) is limited. Here, we sought to identify genes…”
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Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL by Upadhyay, Udita, Zhuang, Gerald Z, Diatchenko, Luda, Parisien, Marc, Kang, Yuan, Sarantopoulos, Konstantinos D, Martin, Eden R, Smith, Shad B, Maixner, William, Levitt, Roy C

“…Carbonic anhydrase-8 (CA8) is an intracellular protein that functions as an allosteric inhibitor of inositol trisphosphate receptor-1 (ITPR1) critical to…”
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Evaluation of copy number variations reveals novel candidate genes in autism spectrum disorder-associated pathways by GRISWOLD, Anthony J, DEQIONG MA, WRIGHT, Harry H, ABRAMSON, Ruth K, WILLIAMS, Scott M, MENON, Ramkumar, MARTIN, Eden R, HAINES, Jonathan L, GILBERT, John R, CUCCARO, Michael L, PERICAK-VANCE, Margaret A, CUKIER, Holly N, NATIONS, Laura D, SCHMIDT, Mike A, CHUNG, Ren-Hua, JAWORSKI, James M, SALYAKINA, Daria, KONIDARI, Loanna, WHITEHEAD, Patrice L

“…Autism spectrum disorders (ASDs) are highly heritable, yet relatively few associated genetic loci have been replicated. Copy number variations (CNVs) have been…”
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Association Between Polymorphisms in DNA Damage Repair Genes and Radiation Therapy–Induced Early Adverse Skin Reactions in a Breast Cancer Population: A Polygenic Risk Score Approach by Lee, Eunkyung, Eum, Sung Y., Slifer, Susan H., Martin, Eden R., Takita, Cristiane, Wright, Jean L., Hines, Robert B., Hu, Jennifer J.

“…Genetic variations in DNA damage repair (DDR) genes may influence radiation therapy (RT)–induced acute normal tissue toxicity in patients with breast cancer…”
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Genome-wide Studies of Copy Number Variation and Exome Sequencing Identify Rare Variants in BAG3 as a Cause of Dilated Cardiomyopathy by Norton, Nadine, Li, Duanxiang, Rieder, Mark J., Siegfried, Jill D., Rampersaud, Evadnie, Züchner, Stephan, Mangos, Steve, Gonzalez-Quintana, Jorge, Wang, Libin, McGee, Sean, Reiser, Jochen, Martin, Eden, Nickerson, Deborah A., Hershberger, Ray E.

“…Dilated cardiomyopathy commonly causes heart failure and is the most frequent precipitating cause of heart transplantation. Familial dilated cardiomyopathy has…”
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