Search Results - "Eden, Georgina"

No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines by Stevens, Natalie E, Ryan, Feargal J, Messina, Nicole L, Blake, Stephen J, Norton, Todd S, Germano, Susie, James, Jane, Eden, Georgina L, Tee, Yee C, Lynn, Miriam A, Botten, Rochelle, Barry, Simone E, Curtis, Nigel, Lynn, David J

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Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy by Kamili, Alvin, Gifford, Andrew J., Li, Nancy, Mayoh, Chelsea, Chow, Shu-Oi, Failes, Timothy W., Eden, Georgina L., Cadiz, Roxanne, Xie, Jinhan, Lukeis, Robyn E., Norris, Murray D., Haber, Michelle, McCowage, Geoffrey B., Arndt, Greg M., Trahair, Toby N., Fletcher, Jamie I.

“…Background Predictive preclinical models play an important role in the assessment of new treatment strategies and as avatar models for personalised medicine;…”
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Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma by Fultang, Livingstone, Gamble, Laura D, Gneo, Luciana, Berry, Andrea M, Egan, Sharon A, De Bie, Fenna, Yogev, Orli, Eden, Georgina L, Booth, Sarah, Brownhill, Samantha, Vardon, Ashley, McConville, Carmel M, Cheng, Paul N, Norris, Murray D, Etchevers, Heather C, Murray, Jayne, Ziegler, David S, Chesler, Louis, Schmidt, Ronny, Burchill, Susan A, Haber, Michelle, De Santo, Carmela, Mussai, Francis

“…Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives…”
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The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life by Lynn, Miriam A., Eden, Georgina, Ryan, Feargal J., Bensalem, Julien, Wang, Xuemin, Blake, Stephen J., Choo, Jocelyn M., Chern, Yee Tee, Sribnaia, Anastasia, James, Jane, Benson, Saoirse C., Sandeman, Lauren, Xie, Jianling, Hassiotis, Sofia, Sun, Emily W., Martin, Alyce M., Keller, Marianne D., Keating, Damien J., Sargeant, Timothy J., Proud, Christopher G., Wesselingh, Steve L., Rogers, Geraint B., Lynn, David J.

“…Studies investigating whether there is a causative link between the gut microbiota and lifespan have largely been restricted to invertebrates or to mice with a…”
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Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis by Bajic, Juliana E, Eden, Georgina L, Lampton, Lorrinne S, Cheah, Ker Y, Lymn, Kerry A, Pei, Jinxin V, Yool, Andrea J, Howarth, Gordon S

“…AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark…”
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Emu Oil Combined with Lyprinol™ Reduces Small Intestinal Damage in a Rat Model of Chemotherapy-Induced Mucositis by Mashtoub, Suzanne, Lampton, Lorrinne S, Eden, Georgina L, Cheah, Ker Y, Lymn, Kerry A, Bajic, Juliana E, Howarth, Gordon S

“…Chemotherapy-induced mucositis is characterized by inflammation and ulcerating lesions lining the alimentary tract. Emu Oil and Lyprinol™ have independently…”
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Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo by Murray, Jayne, Valli, Emanuele, Yu, Denise M.T., Truong, Alan M., Gifford, Andrew J., Eden, Georgina L., Gamble, Laura D., Hanssen, Kimberley M., Flemming, Claudia L., Tan, Alvin, Tivnan, Amanda, Allan, Sophie, Saletta, Federica, Cheung, Leanna, Ruhle, Michelle, Schuetz, John D., Henderson, Michelle J., Byrne, Jennifer A., Norris, Murray D., Haber, Michelle, Fletcher, Jamie I.

“…The ATP-binding cassette transporter ABCC4 (multidrug resistance protein 4, MRP4) mRNA level is a strong predictor of poor clinical outcome in neuroblastoma…”
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A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA and adenovirus vectored vaccines by Ryan, Feargal J., Norton, Todd S., McCafferty, Conor, Blake, Stephen J., Stevens, Natalie E., James, Jane, Eden, Georgina L., Tee, Yee C., Benson, Saoirse C., Masavuli, Makutiro G., Yeow, Arthur E.L., Abayasingam, Arunasingam, Agapiou, David, Stevens, Hannah, Zecha, Jana, Messina, Nicole L., Curtis, Nigel, Ignjatovic, Vera, Monagle, Paul, Tran, Huyen, McFadyen, James D., Bull, Rowena A., Grubor-Bauk, Branka, Lynn, Miriam A., Botten, Rochelle, Barry, Simone E., Lynn, David J.

“…Identifying the molecular mechanisms that promote optimal immune responses to coronavirus disease 2019 (COVID-19) vaccination is critical for future rational…”
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The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota by Blake, Stephen J., James, Jane, Ryan, Feargal J., Caparros-Martin, Jose, Eden, Georgina L., Tee, Yee C., Salamon, John R., Benson, Saoirse C., Tumes, Damon J., Sribnaia, Anastasia, Stevens, Natalie E., Finnie, John W., Kobayashi, Hiroki, White, Deborah L., Wesselingh, Steve L., O’Gara, Fergal, Lynn, Miriam A., Lynn, David J.

“…Immune agonist antibodies (IAAs) are promising immunotherapies that target co-stimulatory receptors to induce potent anti-tumor immune responses, particularly…”
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No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines by Stevens, Natalie E, Ryan, Feargal J, Messina, Nicole L, Blake, Stephen J, Norton, Todd S, Germano, Susie, James, Jane, Eden, Georgina L, Tee, Yee C, Lynn, Miriam A, Botten, Rochelle, Barry, Simone E, Curtis, Nigel, Lynn, David J

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Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma by Gamble, Laura D, Purgato, Stefania, Murray, Jayne, Xiao, Lin, Yu, Denise M T, Hanssen, Kimberley M, Giorgi, Federico M, Carter, Daniel R, Gifford, Andrew J, Valli, Emanuele, Milazzo, Giorgio, Kamili, Alvin, Mayoh, Chelsea, Liu, Bing, Eden, Georgina, Sarraf, Sara, Allan, Sophie, Di Giacomo, Simone, Flemming, Claudia L, Russell, Amanda J, Cheung, Belamy B, Oberthuer, Andre, London, Wendy B, Fischer, Matthias, Trahair, Toby N, Fletcher, Jamie I, Marshall, Glenn M, Ziegler, David S, Hogarty, Michael D, Burns, Mark R, Perini, Giovanni, Norris, Murray D, Haber, Michelle

“…Amplification of the oncogene is associated with an aggressive phenotype and poor outcome in childhood neuroblastoma. Polyamines are highly regulated essential…”
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Targeting metabolic activity in high-risk neuroblastoma through Monocarboxylate Transporter 1 (MCT1) inhibition by Khan, Aaminah, Valli, Emanuele, Lam, Hayley, Scott, David A., Murray, Jayne, Hanssen, Kimberley M., Eden, Georgina, Gamble, Laura D., Pandher, Rupinder, Flemming, Claudia L., Allan, Sophie, Osterman, Andrei L., Haber, Michelle, Norris, Murray D., Fletcher, Jamie I., Yu, Denise M. T.

“…Amplification of the MYCN oncogene occurs in ~25% of primary neuroblastomas and is the single most powerful biological marker of poor prognosis in this…”
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Abstract A35: P-Glycoprotein is a resistance mechanism for conventional induction chemotherapy but not ALK inhibitors in high-risk neuroblastoma by Atkinson, Caroline, Tactacan, Carole, Kamili, Alvin, Saletta, Federica, Gana, Christine, Eden, Georgina, Mayoh, Chelsea, Lock, Richard, Norris, Murray, Haber, Michelle, Gifford, Andrew, Trahair, Toby, Fletcher, Jamie

“…Abstract Background: Despite intensive treatment, patients with high-risk neuroblastoma (HR-NB) have a five-year survival rate of only 50%, largely due to…”
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Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma by Xiao, Lin, Somers, Klaartje, Murray, Jayne, Pandher, Ruby, Karsa, Mawar, Ronca, Emma, Bongers, Angelika, Terry, Rachael, Ehteda, Anahid, Gamble, Laura D, Issaeva, Natalia, Leonova, Katerina I, O'Connor, Aisling, Mayoh, Chelsea, Venkat, Pooja, Quek, Hazel, Brand, Jennifer, Kusuma, Frances K, Pettitt, Jessica A, Mosmann, Erin, Kearns, Adam, Eden, Georgina, Alfred, Stephanie, Allan, Sophie, Zhai, Lei, Kamili, Alvin, Gifford, Andrew J, Carter, Daniel R, Henderson, Michelle J, Fletcher, Jamie I, Marshall, Glenn, Johnstone, Ricky W, Cesare, Anthony J, Ziegler, David S, Gudkov, Andrei V, Gurova, Katerina V, Norris, Murray D, Haber, Michelle

“…We investigated whether targeting chromatin stability through a combination of the curaxin CBL0137 with the histone deacetylase (HDAC) inhibitor, panobinostat,…”
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The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis by Murray, Jayne E., Valli, Emanuele, Milazzo, Giorgio, Mayoh, Chelsea, Gifford, Andrew J., Fletcher, Jamie I., Xue, Chengyuan, Jayatilleke, Nisitha, Salehzadeh, Firoozeh, Gamble, Laura D., Rouaen, Jourdin R. C., Carter, Daniel R., Forgham, Helen, Sekyere, Eric O., Keating, Joanna, Eden, Georgina, Allan, Sophie, Alfred, Stephanie, Kusuma, Frances K., Clark, Ashleigh, Webber, Hannah, Russell, Amanda J., de Weck, Antoine, Kile, Benjamin T., Santulli, Martina, De Rosa, Piergiuseppe, Fleuren, Emmy D. G., Gao, Weiman, Wilkinson-White, Lorna, Low, Jason K. K., Mackay, Joel P., Marshall, Glenn M., Hilton, Douglas J., Giorgi, Federico M., Koster, Jan, Perini, Giovanni, Haber, Michelle, Norris, Murray D.

“…MYCN oncogene amplification is frequently observed in aggressive childhood neuroblastoma. Using an unbiased large-scale mutagenesis screen in…”
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Abstract 4741: Re-evaluating the role of P-glycoprotein in the resistance of high-risk neuroblastoma to standard-of-care chemotherapies by Atkinson, Caroline, Tactacan, Carole M., Kamili, Alvin, Saletta, Federica, Gana, Christine, Eden, Georgina L., Mayoh, Chelsea, Lock, Richard B., Norris, Murray D., Haber, Michelle, Gifford, Andrew J., Trahair, Toby N., Fletcher, Jamie I.

“…Abstract Background: Neuroblastoma is the most common extracranial solid malignancy in children, comprising 15% of cancer related deaths. Despite intensive…”
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Abstract 2884: Establishment of patient-derived xenograft models for high-risk neuroblastoma by Kamili, Alvin, Gifford, Andrew J., Li, Nancy, Mayoh, Chelsea, Eden, Georgina L., Xie, Jinhan, Lukeis, Robyn E., Norris, Murray D., Haber, Michelle, McCowage, Geoffrey, Trahair, Toby N., Fletcher, Jamie I.

“…Abstract Background: High-risk neuroblastoma (HR-NB) accounts for 15% of all pediatric oncology deaths, with long-term survival approximately 50%. Predictive…”
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Abstract 2006: AMX-513 polyamine depletion therapy inhibits tumor growth and reverses immunosuppression in cancers including MYC-driven neuroblastoma and pancreatic cancer by Burns, Mark R., Fosnaugh, Kathy, Palfreyman, Michael G., Gamble, Laura, Murray, Jayne, Allan, Sophie, Eden, Georgina, Sarraf, Sara, Norris, Murray, Ziegler, David, Haber, Michelle

“…Abstract Tumorigenesis is associated with increased polyamine levels and involves the induction of ornithine decarboxylase (ODC), the initial rate-limiting…”
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In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer by Lau, Loretta M S, Mayoh, Chelsea, Xie, Jinhan, Barahona, Paulette, MacKenzie, Karen L, Wong, Marie, Kamili, Alvin, Tsoli, Maria, Failes, Tim W, Kumar, Amit, Mould, Emily V A, Gifford, Andrew, Chow, Shu‐Oi, Pinese, Mark, Fletcher, Jamie I, Arndt, Greg M, Khuong‐Quang, Dong‐Anh, Wadham, Carol, Batey, Daniel, Eden, Georgina, Trebilcock, Peter, Joshi, Swapna, Alfred, Stephanie, Gopalakrishnan, Anjana, Khan, Aaminah, Grebert Wade, Dylan, Strong, Patrick A, Manouvrier, Elodie, Morgan, Lisa T, Span, Miriam, Lim, Jin Yi, Cadiz, Roxanne, Ung, Caitlin, Thomas, David M, Tucker, Katherine M, Warby, Meera, McCowage, Geoffrey B, Dalla‐Pozza, Luciano, Byrne, Jennifer A, Saletta, Federica, Fellowes, Andrew, Fox, Stephen B, Norris, Murray D, Tyrrell, Vanessa, Trahair, Toby N, Lock, Richard B, Cowley, Mark J, Ekert, Paul G, Haber, Michelle, Ziegler, David S, Marshall, Glenn M

“…Biomarkers which better match anticancer drugs with cancer driver genes hold the promise of improved clinical responses and cure rates. We developed a…”
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Macrophage-derived IL-1β and TNF-α regulate arginine metabolism in neuroblastoma by Fultang, Livingstone, Gamble, Laura D., Gneo, Luciana, Berry, Andrea M., Egan, Sharon A., De Bie, Fenna, Yogev, Orli, Eden, Georgina L., Booth, Sarah, Brownhill, Samantha, Vardon, Ashley, McConville, Carmel M., Cheng, Paul N., Norris, Murray D., Etchevers, Heather C., Murray, Jayne, Ziegler, David S., Chesler, Louis, Schmidt, Ronny, Burchill, Susan A., Haber, Michelle, De Santo, Carmela, Mussai, Francis

“…Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives…”
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