Search Results - "Edelstein, C"

The role of platelet microvesicles in intercellular communication by Edelstein, Leonard C.

“…In recent years, there has been exponential growth in the interest in microvesicles, which is reflected by the number of publications. Initially referred to as…”
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MicroRNAs in platelet production and activation by Edelstein, Leonard C., Bray, Paul F.

“…MicroRNAs are small RNA molecules that modulate protein expression by degrading mRNA or repressing translation. They have been shown to play important roles in…”
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Urine NGAL and IL‐18 are Predictive Biomarkers for Delayed Graft Function Following Kidney Transplantation by Parikh, C. R., Jani, A., Mishra, J., Ma, Q., Kelly, C., Barasch, J., Edelstein, C. L., Devarajan, P.

“…Delayed graft function (DGF) due to tubule cell injury frequently complicates deceased donor kidney transplants. We tested whether urinary neutrophil…”
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Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery by Parikh, C.R., Mishra, J., Thiessen-Philbrook, H., Dursun, B., Ma, Q., Kelly, C., Dent, C., Devarajan, P., Edelstein, C.L.

“…Acute kidney injury (AKI) is a frequent complication of cardiopulmonary bypass (CPB). The lack of early biomarkers for AKI has impaired our ability to…”
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Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c by Edelstein, Leonard C, Simon, Lukas M, Montoya, Raúl Teruel, Holinstat, Michael, Chen, Edward S, Bergeron, Angela, Kong, Xianguo, Nagalla, Srikanth, Mohandas, Narla, Cohen, David E, Dong, Jing-fei, Shaw, Chad, Bray, Paul F

“…In exploring the possibility that racial differences in platelet function might exist, Paul Bray and his colleagues report that platelets from blacks have a…”
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MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression by Teruel-Montoya, Raul, Kong, Xianguo, Abraham, Shaji, Ma, Lin, Kunapuli, Satya P, Holinstat, Michael, Shaw, Chad A, McKenzie, Steven E, Edelstein, Leonard C, Bray, Paul F

“…Blood microRNA (miRNA) levels have been associated with and shown to participate in disease pathophysiology. However, the hematopoietic cell of origin of blood…”
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Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race by Edelstein, Leonard C., Simon, Lukas M., Lindsay, Cory R., Kong, Xianguo, Teruel-Montoya, Raúl, Tourdot, Benjamin E., Chen, Edward S., Ma, Lin, Coughlin, Shaun, Nieman, Marvin, Holinstat, Michael, Shaw, Chad A., Bray, Paul F.

“…Human platelets express 2 thrombin receptors: protease-activated receptor (PAR)-1 and PAR4. Recently, we reported 3.7-fold increased PAR4-mediated aggregation…”
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The complex transcriptional landscape of the anucleate human platelet by Bray, Paul F, McKenzie, Steven E, Edelstein, Leonard C, Nagalla, Srikanth, Delgrosso, Kathleen, Ertel, Adam, Kupper, Joan, Jing, Yi, Londin, Eric, Loher, Phillipe, Chen, Huang-Wen, Fortina, Paolo, Rigoutsos, Isidore

“…Human blood platelets are essential to maintaining normal hemostasis, and platelet dysfunction often causes bleeding or thrombosis. Estimates of genome-wide…”
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Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics by Tourdot, Benjamin E, Stoveken, Hannah, Trumbo, Derek, Yeung, Jennifer, Kanthi, Yogendra, Edelstein, Leonard C, Bray, Paul F, Tall, Gregory G, Holinstat, Michael

“…OBJECTIVE—Platelet activation after stimulation of PAR (protease-activated receptor) 4 is heightened in platelets from blacks compared with those from whites…”
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Mechanism of Race-Dependent Platelet Activation Through the Protease-Activated Receptor-4 and Gq Signaling Axis by Tourdot, Benjamin E, Conaway, Stanley, Niisuke, Katrin, Edelstein, Leonard C, Bray, Paul F, Holinstat, Michael

“…OBJECTIVE—Black individuals are at an increased risk of myocardial infarction and stroke, 2 vascular diseases with strong thrombotic components. Platelet…”
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Cytokines in acute kidney injury (AKI) by Lee, D W, Faubel, S, Edelstein, C L

“…In acute kidney injury (AKI), many cytokines are released by leukocytes and renal tubular cells in the injured kidney and are important components of both the…”
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Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood by Bhatlekar, Seema, Basak, Indranil, Edelstein, Leonard C, Campbell, Robert A, Lindsey, Cory R, Italiano, Jr, Joseph E, Weyrich, Andrew S, Rowley, Jesse W, Rondina, Matthew T, Sola-Visner, Martha, Bray, Paul F

“…Apoptosis is a recognized limitation to generating large numbers of megakaryocytes in culture. The genes responsible have been rigorously studied in mice, but…”
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miR‐15a‐5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway by Basak, Indranil, Bhatlekar, Seema, Manne, Bhanu K., Stoller, Micelle, Hugo, Sarah, Kong, X., Ma, L., Rondina, Matthew T., Weyrich, Andrew S., Edelstein, Leonard C., Bray, Paul F.

“…Essentials The action of microRNAs (miRs) in human megakaryocyte signaling is largely unknown. Cord blood‐derived human megakaryocytes (MKs) were used to test…”
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The SCAN domain family of zinc finger transcription factors by Edelstein, Leonard C., Collins, Tucker

“…Zinc finger transcription factor genes represent a significant portion of the genes in the vertebrate genome. Some Cys 2His 2 type zinc fingers are associated…”
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Functionalization of CD36 cardiovascular disease and expression associated variants by interdisciplinary high throughput analysis by Madan, Namrata, Ghazi, Andrew R, Kong, Xianguo, Chen, Edward S, Shaw, Chad A, Edelstein, Leonard C

“…CD36 is a platelet membrane glycoprotein whose engagement with oxidized low-density lipoprotein (oxLDL) results in platelet activation. The CD36 gene has been…”
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MicroRNAs in platelet production and activation by Edelstein, L. C., McKenzie, S. E., Shaw, C., Holinstat, M. A., Kunapuli, S. P., Bray, P. F.

“…Summary Recent work by the Encyclopedia of DNA Elements project showed that non‐protein‐coding RNAs account for an unexpectedly large proportion of the human…”
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Bayesian modelling of high-throughput sequencing assays with malacoda by Ghazi, Andrew R, Kong, Xianguo, Chen, Ed S, Edelstein, Leonard C, Shaw, Chad A

“…NGS studies have uncovered an ever-growing catalog of human variation while leaving an enormous gap between observed variation and experimental…”
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Integrative Multi-omic Analysis of Human Platelet eQTLs Reveals Alternative Start Site in Mitofusin 2 by Simon, Lukas M., Chen, Edward S., Edelstein, Leonard C., Kong, Xianguo, Bhatlekar, Seema, Rigoutsos, Isidore, Bray, Paul F., Shaw, Chad A.

“…Platelets play a central role in ischemic cardiovascular events. Cardiovascular disease (CVD) is a major cause of death worldwide. Numerous genome-wide…”
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Effect of Sirolimus on Native Total Kidney Volume After Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease: A Randomized Controlled Pilot Study by Davis, S., Gralla, J., Chan, L., Wiseman, A., Edelstein, C.L.

“…The mammalian target of rapamycin (mTOR) pathway has been shown to be central to cyst formation and growth in patients with autosomal dominant polycystic…”
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VEGF receptor inhibition slows the progression of polycystic kidney disease by Tao, Y., Kim, J., Yin, Y., Zafar, I., Falk, S., He, Z., Faubel, S., Schrier, R.W., Edelstein, C.L.

“…Although the receptors for vascular endothelial growth factor (VEGF) exert their effects on vasculogenesis and angiogenesis through receptors located on…”
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