Localization of hyaluronan in regions of the human female reproductive tract

Accumulation of hyaluronan has previously been observed in various organs as an inflammatory response. To study the presumed connection between infertility due to a tubal factor and inflammation, we performed an analysis of the hyaluronan distribution in biopsy specimens from the female reproductive...

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Bibliographic Details
Published in:	The journal of histochemistry and cytochemistry Vol. 39; no. 8; pp. 1131 - 1135
Main Authors:	Edelstam, GA, Lundkvist, OE, Wells, AF, Laurent, TC
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA Histochemical Soc 01-08-1991 SAGE Publications Histochemical Society
Subjects:	Biological and medical sciences Biopsy Cell Division - physiology Cell structures and functions Endometrium - chemistry Endometrium - cytology Fallopian Tube Diseases - metabolism Fallopian Tube Diseases - pathology Fallopian Tubes - chemistry Fallopian Tubes - cytology Female Fundamental and applied biological sciences. Psychology Histocytochemistry Humans Hyaluronic Acid - analysis Infertility, Female - metabolism Infertility, Female - pathology Molecular and cellular biology Tissue Adhesions - metabolism Tissue Adhesions - pathology Human Hyaluronic acid Localization Genital system
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Summary:	Accumulation of hyaluronan has previously been observed in various organs as an inflammatory response. To study the presumed connection between infertility due to a tubal factor and inflammation, we performed an analysis of the hyaluronan distribution in biopsy specimens from the female reproductive tract, using a biotinylated hyaluronan binding protein (HABP) as a histochemical probe. In normal specimens hyaluronan was localized in the dense, irregular connective tissue surrounding blood vessels of various sizes. Smooth muscle and columnar epithelium were devoid of hyaluronan. The isthmic part of the normal Fallopian tube showed moderately intense staining of the entire lamina propria, whereas normal fimbriae stained weakly. No cyclic changes in hyaluronan content were observed. In biopsy specimens from women with infertility due to a tubal factor, intense staining, stronger than in normal tubes, was detected in the adhesions and in the lamina propria of sactosalpinx. This may indicate that infertility due to a tubal factor is associated with an ongoing inflammatory and/or proliferative process.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-1554 1551-5044
DOI:	10.1177/39.8.1856461