Search Results - "Edelmann, Martin"

Radiolabelling small and biomolecules for tracking and monitoring by Edelmann, Martin R

“…Radiolabelling small molecules with beta-emitters has been intensively explored in the last decades and novel concepts for the introduction of radionuclides…”
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Functional in vitro assessment of modified antibodies: Impact of label on protein properties by Edelmann, Martin R, Hauri, Simon

“…Labelling of therapeutic antibodies with radionuclides or fluorophores is routinely used to study their pharmacokinetic properties. A critical assumption in…”
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Tritium O‑Methylation of N‑Alkoxy Maleimide Derivatives as Labeling Reagents for Biomolecules by Edelmann, Martin R, Muser, Thorsten

“…An efficient procedure to access tritium-labeled maleimide derivatives in a high specific activity has been developed. N-Substituted maleimides containing the…”
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Evolving Escherichia coli to use a tRNA with a non-canonical fold as an adaptor of the genetic code by Edelmann, Martin P, Couperus, Sietse, Rodríguez-Robles, Emilio, Rivollier, Julie, Roberts, Tania M, Panke, Sven, Marlière, Philippe

“…All known bacterial tRNAs adopt the canonical cloverleaf 2D and L-shaped 3D structures. We aimed to explore whether alternative tRNA structures could be…”
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Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges by Schadt, Simone, Hauri, Simon, Lopes, Filipe, Edelmann, Martin R, Staack, Roland F, Villaseñor, Roberto, Kettenberger, Hubert, Roth, Adrian B, Schuler, Franz, Richter, Wolfgang F, Funk, Christoph

“…For therapeutic proteins, the currently established standard development path generally does not foresee biotransformation studies by default because it is…”
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Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer’s Disease with Positron Emission Tomography by Gobbi, Luca C, Knust, Henner, Körner, Matthias, Honer, Michael, Czech, Christian, Belli, Sara, Muri, Dieter, Edelmann, Martin R, Hartung, Thomas, Erbsmehl, Isabella, Grall-Ulsemer, Sandra, Koblet, Andreas, Rueher, Marianne, Steiner, Sandra, Ravert, Hayden T, Mathews, William B, Holt, Daniel P, Kuwabara, Hiroto, Valentine, Heather, Dannals, Robert F, Wong, Dean F, Borroni, Edilio

“…Aggregates of tau and beta amyloid (Aβ) plaques constitute the histopathological hallmarks of Alzheimer’s disease and are prominent targets for novel…”
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Antibody-Based In Vivo Imaging of Central Nervous System Targets-Evaluation of a Pretargeting Approach Utilizing a TCO-Conjugated Brain Shuttle Antibody and Radiolabeled Tetrazines by Bredack, Christoph, Edelmann, Martin R, Borroni, Edilio, Gobbi, Luca C, Honer, Michael

“…Bioorthogonal pretargeted imaging using the inverse-electron-demand Diels-Alder (IEDDA) reaction between a tetrazine (Tz) and a -cyclooctene (TCO) represents…”
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A Brief Review of Radiolabelling Nucleic Acid‐Based Molecules for Tracking and Monitoring by Edelmann, Martin R., Sladojevich, Filippo, Husbands, Stephen M., Otteneder, Michael B., Blagbrough, Ian S.

“…ABSTRACT The rise of nucleic acid‐based therapeutics continues apace. At the same time, the need for radiolabelled oligonucleotides for determination of…”
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Biodistribution of Drug/ADA Complexes: The Impact of Immune Complex Formation on Antibody Distribution by Opolka-Hoffmann, Eugenia, Edelmann, Martin R., Otteneder, Michael B., Hauri, Simon, Jordan, Gregor, Schrag, Peter, Lechmann, Martin, Winter, Gerhard, Staack, Roland F.

“…The clinical use of therapeutic monoclonal antibodies (mAbs) for the treatment of cancer, inflammation, and other indications has been successfully…”
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Evaluation of Tetrazine Tracers for Pretargeted Imaging within the Central Nervous System by Edelmann, Martin R., Bredack, Christoph, Belli, Sara, Mohr, Peter, Imhoff, Marie-Paule, Reggiani, Flore, Kusznir, Eric A., Rufer, Arne C., Holt, Daniel P., Valentine, Heather, Wong, Dean F., Dannals, Robert F., Honer, Michael, Gobbi, Luca C.

“…The pretargeting approach separates the biological half-life of an antibody from the physical half-life of the radioisotope label, providing a strategy for…”
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Tools for work‐up and prepurification of tritium‐labeled small molecules by Muri, Dieter, Edelmann, Martin R.

“…This practitioner protocol describes the use and application of different types of solid‐phase extractions and metal scavengers for small‐scale reactions,…”
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Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain by He, Yingfang, Grether, Uwe, Taddio, Marco F., Meier, Carla, Keller, Claudia, Edelmann, Martin R., Honer, Michael, Huber, Sylwia, Wittwer, Matthias B., Heer, Dominik, Richter, Hans, Collin, Ludovic, Hug, Melanie N., Hilbert, Manuel, Postmus, Annemarieke G.J., Stevens, Anna Floor, van der Stelt, Mario, Krämer, Stefanie D., Schibli, Roger, Mu, Linjing, Gobbi, Luca C.

“…Monoacylglycerol lipase (MAGL) is a gatekeeper in regulating endocannabinoid signaling and has gained substantial attention as a therapeutic target for…”
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Tritium Labeling of Neuromedin S by Conjugation with [3H]N‑Succinimidyl Propionate by Edelmann, Martin R., Erny, Johannes, Guba, Wolfgang, Hierl, Markus

“…The human neuropeptide neuromedin S (NMS) consists of 33 amino acids. The introduction of tritium atoms into NMS has not been described so far. This represents…”
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Radiolabeled IgG antibodies: Impact of various labels on neonatal Fc receptor binding by Edelmann, Martin R., Kettenberger, Hubert, Knaupp, Alexander, Schlothauer, Tilman, Otteneder, Michael B.

“…The number of therapeutic antibodies in research and development as well as their complexity increases from year to year. Novel therapeutic protein formats,…”
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Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms by Jaramillo, Claudia A Castro, Belli, Sara, Cascais, Anne-Christine, Dudal, Sherri, Edelmann, Martin R, Haak, Markus, Brun, Marie-Elise, Otteneder, Michael B, Ullah, Mohammed, Funk, Christoph, Schuler, Franz, Simon, Silke

“…Monoclonal antibodies (mAbs) are a rapidly growing drug class for which great efforts have been made to optimize certain molecular features to achieve the…”
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Tritium labeling of antisense oligonucleotides via different conjugation agents by Edelmann, Martin R., Husser, Christophe, Duschmalé, Martina B., Fischer, Guy, Senn, Claudia, Koller, Erich, Brink, Andreas

“…A novel approach to tritium-labeled antisense oligonucleotides (ASO) was established by conjugating N -succinimidyl propionate, as well as…”
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Surgical site, gender, and place of residence influence the time to resume driving after total joint arthroplasty by Lazar, Tiberiu-Adrian, Edelmann, Martin, Awiszus, Friedemann, Lohmann, Christoph H.

“…Abstract Background For a large proportion of the population, especially those residing in the countryside, the use of a car for daily activities is…”
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Synthesis of enantiomerically pure [14C]-labelled morpholine derivatives for a class of trace amine-associate receptor 1 agonists by Edelmann, Martin R., Hartung, Thomas, Trussardi, René, Iding, Hans, Galley, Guido, Pflieger, Philippe, Norcross, Roger D.

“…Various agonists of the trace amine‐associate receptor 1, under consideration as potential clinical development candidates, were labelled with carbon‐14 for…”
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Altered Ca2+-homeostasis of cisplatin-treated and low level resistant non-small-cell and small-cell lung cancer cells by Schrödl, Kathrin, Oelmez, Hamza, Edelmann, Martin, Huber, Rudolf Maria, Bergner, Albrecht

“…Chemotherapy often leads to encouraging responses in lung cancer. But, in the course of the treatment, resistance to chemotherapy ultimately limits the life…”
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O-04 - Development of a novel reversible monoacylglycerol lipase PET tracer bearing a morpholine-3-one scaffold by He, Yingfang, Grether, Uwe, Taddio, Marco, Keller, Claudia, Honer, Michael, Huber, Sywia, Edelmann, Martin, Krämer, Stefanie, Schibli, Roger, Gobbi, Luca, Mu, Linjing

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