Search Results - "Edelman, Elena"

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells by Yang, Wanjuan, Soares, Jorge, Greninger, Patricia, Edelman, Elena J, Lightfoot, Howard, Forbes, Simon, Bindal, Nidhi, Beare, Dave, Smith, James A, Thompson, I Richard, Ramaswamy, Sridhar, Futreal, P Andrew, Haber, Daniel A, Stratton, Michael R, Benes, Cyril, McDermott, Ultan, Garnett, Mathew J

“…Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The…”
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Pharmacogenomic agreement between two cancer cell line data sets by Stransky, Nicolas, Ghandi, Mahmoud, Kryukov, Gregory V, Garraway, Levi A, Lehár, Joseph, Liu, Manway, Sonkin, Dmitriy, Kauffmann, Audrey, Venkatesan, Kavitha, Edelman, Elena J, Riester, Markus, Barretina, Jordi, Caponigro, Giordano, Schlegel, Robert, Sellers, William R, Stegmeier, Frank, Morrissey, Michael, Amzallag, Arnaud, Pruteanu-Malinici, Iulian, Haber, Daniel A, Ramaswamy, Sridhar, Benes, Cyril H, Menden, Michael P, Iorio, Francesco, Stratton, Michael R, McDermott, Ultan, Garnett, Mathew J, Saez-Rodriguez, Julio

“…Large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti-cancer drug response. Here we…”
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Systematic identification of genomic markers of drug sensitivity in cancer cells by Garnett, Mathew J., Edelman, Elena J., Heidorn, Sonja J., Greenman, Chris D., Dastur, Anahita, Lau, King Wai, Greninger, Patricia, Thompson, I. Richard, Luo, Xi, Soares, Jorge, Liu, Qingsong, Iorio, Francesco, Surdez, Didier, Chen, Li, Milano, Randy J., Bignell, Graham R., Tam, Ah T., Davies, Helen, Stevenson, Jesse A., Barthorpe, Syd, Lutz, Stephen R., Kogera, Fiona, Lawrence, Karl, McLaren-Douglas, Anne, Mitropoulos, Xeni, Mironenko, Tatiana, Thi, Helen, Richardson, Laura, Zhou, Wenjun, Jewitt, Frances, Zhang, Tinghu, O’Brien, Patrick, Boisvert, Jessica L., Price, Stacey, Hur, Wooyoung, Yang, Wanjuan, Deng, Xianming, Butler, Adam, Choi, Hwan Geun, Chang, Jae Won, Baselga, Jose, Stamenkovic, Ivan, Engelman, Jeffrey A., Sharma, Sreenath V., Delattre, Olivier, Saez-Rodriguez, Julio, Gray, Nathanael S., Settleman, Jeffrey, Futreal, P. Andrew, Haber, Daniel A., Stratton, Michael R., Ramaswamy, Sridhar, McDermott, Ultan, Benes, Cyril H.

“…Clinical responses to anticancer therapies are often restricted to a subset of patients. In some cases, mutated cancer genes are potent biomarkers for…”
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Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer by Faber, Anthony C., Farago, Anna F., Costa, Carlotta, Dastur, Anahita, Gomez-Caraballo, Maria, Robbins, Rebecca, Wagner, Bethany L., Rideout, William M., Jakubik, Charles T., Ham, Jungoh, Edelman, Elena J., Ebi, Hiromichi, Yeo, Alan T., Hata, Aaron N., Song, Youngchul, Patel, Neha U., March, Ryan J., Tam, Ah Ting, Milano, Randy J., Boisvert, Jessica L., Hicks, Mark A., Elmiligy, Sarah, Malstrom, Scott E., Rivera, Miguel N., Harada, Hisashi, Windle, Brad E., Ramaswamy, Sridhar, Benes, Cyril H., Jacks, Tyler, Engelman, Jeffrey A.

“…BH3 mimetics such as ABT-263 induce apoptosis in a subset of cancer models. However, these drugs have shown limited clinical efficacy as single agents in…”
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mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1 by Faber, Anthony C, Coffee, Erin M, Costa, Carlotta, Dastur, Anahita, Ebi, Hiromichi, Hata, Aaron N, Yeo, Alan T, Edelman, Elena J, Song, Youngchul, Tam, Ah Ting, Boisvert, Jessica L, Milano, Randy J, Roper, Jatin, Kodack, David P, Jain, Rakesh K, Corcoran, Ryan B, Rivera, Miguel N, Ramaswamy, Sridhar, Hung, Kenneth E, Benes, Cyril H, Engelman, Jeffrey A

“…Colorectal cancers harboring KRAS or BRAF mutations are refractory to current targeted therapies. Using data from a high-throughput drug screen, we have…”
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Modeling cancer progression via pathway dependencies by Edelman, Elena J, Guinney, Justin, Chi, Jen-Tsan, Febbo, Phillip G, Mukherjee, Sayan

“…Cancer is a heterogeneous disease often requiring a complexity of alterations to drive a normal cell to a malignancy and ultimately to a metastatic state…”
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A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration by Smolen, Gromoslaw A, Zhang, Jianmin, Zubrowski, Matthew J, Edelman, Elena J, Luo, Biao, Yu, Min, Ng, Lydia W, Scherber, Cally M, Schott, Benjamin J, Ramaswamy, Sridhar, Irimia, Daniel, Root, David E, Haber, Daniel A

“…To define the functional pathways regulating epithelial cell migration, we performed a genome-wide RNAi screen using 55,000 pooled lentiviral shRNAs targeting…”
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Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma by Chen, Eleanor Y, Dobrinski, Kimberly P, Brown, Kim H, Clagg, Ryan, Edelman, Elena, Ignatius, Myron S, Chen, Jin Yun Helen, Brockmann, Jillian, Nielsen, G Petur, Ramaswamy, Sridhar, Keller, Charles, Lee, Charles, Langenau, David M

“…Human cancer genomes are highly complex, making it challenging to identify specific drivers of cancer growth, progression, and tumor maintenance. To bypass…”
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genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities by Garman, Katherine S, Acharya, Chaitanya R, Edelman, Elena, Grade, Marian, Gaedcke, Jochen, Sud, Shivani, Barry, William, Diehl, Anna Mae, Provenzale, Dawn, Ginsburg, Geoffrey S, Ghadimi, B. Michael, Ried, Thomas, Nevins, Joseph R, Mukherjee, Sayan, Hsu, David, Potti, Anil

“…Gene expression profiles provide an opportunity to dissect the heterogeneity of solid tumors, including colon cancer, to improve prognosis and predict response…”
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Analysis of sample set enrichment scores: assaying the enrichment of sets of genes for individual samples in genome-wide expression profiles by Edelman, Elena, Porrello, Alessandro, Guinney, Justin, Balakumaran, Bala, Bild, Andrea, Febbo, Phillip G., Mukherjee, Sayan

“…Motivation: Gene expression profiling experiments in cell lines and animal models characterized by specific genetic or molecular perturbations have yielded…”
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Abstract 2179: Computational pharmacogenomics analysis of human cancer cell lines by Edelman, Elena

“…Purpose: The goal of this study is to use cell-based drug screening and genome-wide molecular information to identify fundamental genomic alterations useful…”
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Consistency of drug profiles and predictors in large-scale cancer cell line data by Stransky, Nicolas, Ghandi, Mahmoud, Kryukov, Gregory V., Garraway, Levi A., Amzallag, Arnaud, Pruteanu-Malinici, Iulian, Haber, Daniel A., Ramaswamy, Sridhar, Benes, Cyril H., Lehár, Joseph, Liu, Manway, Sonkin, Dmitriy, Kauffmann, Audrey, Venkatesan, Kavitha, Edelman, Elena J., Riester, Markus, Barretina, Jordi, Caponigro, Giordano, Schlegel, Robert, Sellers, William, Stegmeier, Frank, Morrissey, Michael, Menden, Michael P., Iorio, Francesco, Stratton, Michael R., McDermott, Ultan, Saez-Rodriguez, Julio, Garnett, Mathew J.

“…Large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti-cancer drug response. Here, we…”
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Abstract 1412: Cross-species array comparative genomic hybridization identifies novel driver genes in embryonal rhabdomyosarcoma by Chen, Eleanor, Dobrinski, Kimberly P., Brown, Kim H., Clagg, Ryan, Edelman, Elena, Ignatius, Myron, Brockmann, Jillian, Nielsen, G. Petur, Ramaswamy, Sridhar, Keller, Charles, Lee, Charles, Langenau, David M.

“…Human cancers are often associated with large chromosomal amplifications and deletions comprising megabases of sequence - making it challenging to identify…”
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Abstract 2206: Genomics of Drug Sensitivity in Cancer (GDSC): A resource for therapeutic biomarker discovery in cancer cells by Yang, Wanjuan, Soares, Jorge, Greninger, Patricia, Edelman, Elena, Lightfoot, Howard, Forbes, Simon, Sridhar, Ramaswamy, Futreal, P. Andrew, Haber, Daniel, Stratton, Michael, Benes, Cyril, McDermott, Ultan, Garnett, Mathew

“…The Genomic of Drug Sensitivity in Cancer (GDSC; www.cancerRxgene.org) resource facilitates development of targeted cancer therapies through pre-clinical…”
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Cross-Species Array Comparative Genomic Hybridization Identifies Novel Oncogenic Events in Zebrafish and Human Embryonal Rhabdomyosarcoma: e1003727 by Chen, Eleanor Y, Dobrinski, Kimberly P, Brown, Kim H, Clagg, Ryan, Edelman, Elena, Ignatius, Myron S, Chen, Jin YunHelen, Brockmann, Jillian, Nielsen, G Petur, Ramaswamy, Sridhar, Keller, Charles, Lee, Charles, Langenau, David M

“…Human cancer genomes are highly complex, making it challenging to identify specific drivers of cancer growth, progression, and tumor maintenance. To bypass…”
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Retraction for Garman et al., A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities by Garman, Katherine S, Acharya, Chaitanya R, Edelman, Elena, Grade, Marian, Gaedcke, Jochen, Sud, Shivani, Barry, William, Diehl, Anna Mae, Provenzale, Dawn, Ginsburg, Geoffrey S, Ghadimi, B Michael, Ried, Thomas, Nevins, Joseph R, Mukherjee, Sayan, Hsu, David, Potti, Anil

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RETRACTED: A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities by Garman, Katherine S., Acharya, Chaitanya R., Edelman, Elena, Grade, Marian, Gaedcke, Jochen, Sud, Shivani, Barry, William, Diehl, Anna Mae, Provenzale, Dawn, Ginsburg, Geoffrey S., Ghadimi, B. Michael, Ried, Thomas, Nevins, Joseph R., Mukherjee, Sayan, Hsu, David, Potti, Anil

“…Gene expression profiles provide an opportunity to dissect the heterogeneity of solid tumors, including colon cancer, to improve prognosis and predict response…”
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Modeling cancer progression on the pathway level by Edelman, Elena

“…Over the past several decades, many genes have been discovered that govern important functions in the development of a variety of different cancers. However,…”
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Modeling cancer progression on the pathway level by Edelman, Elena

“…Over the past several decades, many genes have been discovered that govern important functions in the development of a variety of different cancers. However,…”
Get full text