Multi-elemental characterization of soft biological tissues by inductively coupled plasma–sector field mass spectrometry

The performance of double-focusing, sector field ICP–MS (ICP–SFMS) for the multi-elemental analysis of soft tissues following microwave-assisted digestion with nitric acid was evaluated and factors affecting method limits of detection discussed. Accuracy was assessed by replicate analyses of certifi...

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Bibliographic Details
Published in:	Analytica chimica acta Vol. 521; no. 2; pp. 123 - 135
Main Authors:	Engström, Emma, Stenberg, Anna, Senioukh, Svetlana, Edelbro, Roland, Baxter, Douglas C, Rodushkin, Ilia
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01-09-2004 Elsevier
Subjects:	Analytical chemistry Applied Geology Biological tissues Chemistry Digestion Exact sciences and technology Inductively coupled plasma–sector field mass spectrometry Multi-elemental analysis Spectrometric and optical methods Tillämpad geologi Inductively coupled plasma–sector field mass spectrometry Digestion Biological tissues Multi-elemental analysis Performance evaluation Elements Replica method Inductive coupling plasma spectrometry Double focusing spectrometer Tissue Accuracy Emission spectrometry Microwave oven Detection limit Pisces Standard deviation Trace analysis Optical spectrometry Coupled method Certified reference material Nitric acid Vertebrata Multicomponent analysis Acid digestion Reference material Inductively coupled plasma-sector field mass spectrometry Mass spectrometry Comparative study
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Summary:	The performance of double-focusing, sector field ICP–MS (ICP–SFMS) for the multi-elemental analysis of soft tissues following microwave-assisted digestion with nitric acid was evaluated and factors affecting method limits of detection discussed. Accuracy was assessed by replicate analyses of certified reference materials and by participation in performance evaluation programs; the precision was better than 5% relative standard deviation (RSD) for the majority of elements. Cl was the only element for which ICP–SFMS data consistently deviated from certified concentrations in the reference materials tested. Comparison between results obtained by ICP–SFMS and ICP optical emission spectrometry showed good agreement for elements present in tissues at concentrations above 2 μg g −1. The concentrations of 68 elements in different fish and animal soft tissues (muscle, liver, kidney, lung and brain) are presented, and, where possible, compared with previously published data.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0003-2670 1873-4324 1873-4324
DOI:	10.1016/j.aca.2004.06.030