Search Results - "Edelberg, J M"

Molecular enhancement of porcine cardiac chronotropy by Edelberg, J M, Huang, D T, Josephson, M E, Rosenberg, R D

“…OBJECTIVE To test the potential of gene transfer approaches to enhance cardiac chronotropy in a porcine system as a model of the human heart. METHODS Plasmids…”
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p38 mitogen‐activated protein kinase targets the production of proinflammatory endothelial microparticles by CURTIS, A. M., WILKINSON, P. F., GUI, M., GALES, T. L., HU, E., EDELBERG, J. M.

“…Background: Endothelial microparticles (EMPs) are irregularly shaped membrane fragments shed into the circulation in patients with vascular diseases, and may…”
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Young Adult Bone Marrow–Derived Endothelial Precursor Cells Restore Aging-Impaired Cardiac Angiogenic Function by Edelberg, Jay M, Tang, Lilong, Hattori, Koichi, Lyden, David, Rafii, Shahin

“…Delivery of young bone marrow–derived stem cells offers a novel approach for restoring the impaired senescent cardiac angiogenic function that may underlie the…”
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Kinetic analysis of the effects of glycosaminoglycans and lipoproteins on urokinase-mediated plasminogen activation by EDELBERG, J. M, WEISSLER, M, PIZZO, S. V

“…The glycosaminoglycans (GAGs) heparin, heparan sulphate and chondroitin 6-sulphate stimulate the rate of urokinase activation of human plasminogen. Kinetic…”
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Targeted disruption of cd39 /ATP diphosphohydrolase results in disordered hemostasis and thromboregulation by Rosenberg, Robert D, Enjyoji, Keiichi, Sévigny, Jean, Lin, Yuan, Frenette, Paul S, Christie, Patricia D, Esch, Jan Schulte Am, Imai, Masato, Edelberg, Jay M, Rayburn, Helen, Lech, Miroslaw, Beeler, David L, Csizmadia, Eva, Wagner, Denisa D, Robson, Simon C

“…CD39, or vascular adenosine triphosphate diphosphohydrolase, has been considered an important inhibitor of platelet activation. Unexpectedly, cd39-deficient…”
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The inhibition of tissue type plasminogen activator by plasminogen activator inhibitor-1. The effects of fibrinogen, heparin, vitronectin, and lipoprotein(a) by Edelberg, J M, Reilly, C F, Pizzo, S V

“…Plasminogen activator inhibitor-1 (PAI-1) regulates fibrinolysis by inhibiting tissue type plasminogen activator (t-PA). Fibrinogen, heparin, and vitronectin…”
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Kinetic analysis of the effects of heparin and lipoproteins on tissue plasminogen activator mediated plasminogen activation by Edelberg, Jay M, Pizzo, Salvatore V

“…Heparin sulfate and the less sulfated glycosaminoglycan heparan sulfate enhance human plasminogen (Pg) conversion to plasmin by tissue-type plasminogen…”
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Platelet-Derived Growth Factor-AB Promotes the Generation of Adult Bone Marrow–Derived Cardiac Myocytes by Xaymardan, Munira, Tang, Lilong, Zagreda, Leze, Pallante, Benedetta, Zheng, Jingang, Chazen, Joseph L, Chin, Andrew, Duignan, Inga, Nahirney, Patrick, Rafii, Shahin, Mikawa, Takashi, Edelberg, Jay M

“…ABSTRACT—The directed generation of cardiac myocytes from endogenous stem cells offers the potential for novel therapies for cardiovascular disease. To…”
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A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state by Weiler-Guettler, H, Christie, P D, Beeler, D L, Healy, A M, Hancock, W W, Rayburn, H, Edelberg, J M, Rosenberg, R D

“…The activity of the coagulation system is regulated, in part, by the interaction of thrombin with the endothelial cell receptor thrombomodulin with subsequent…”
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Lipoprotein(a) inhibition of plasminogen activation by tissue-type plasminogen activator by Edelberg, J M, Gonzalez-Gronow, M, Pizzo, S V

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Vascular Bed-Specific Expression of an Endothelial Cell Gene Is Programmed by the Tissue Microenvironment by Aird, William C., Edelberg, Jay M., Weiler-Guettler, Hartmut, Simmons, William W., Smith, Thomas W., Rosenberg, Robert D.

“…The endothelium is morphologically and functionally adapted to meet the unique demands of the underlying tissue. At the present time, little is known about the…”
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Lipoprotein(a) inhibits plasminogen activation in a template-dependent manner by Edelberg, J M, Pizzo, S V

“…Lipoprotein(a) [Lp(a)] is a low density lipoprotein whose plasma levels strongly correlate with the occurrence of atherosclerotic disease. Structural studies…”
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Senescent impairment in synergistic cytokine pathways that provide rapid cardioprotection in the rat heart by Xaymardan, Munira, Zheng, Jingang, Duignan, Inga, Chin, Andrew, Holm, Jacquelyne M, Ballard, Victoria L T, Edelberg, Jay M

“…Pretreatment of rodent hearts with platelet-derived growth factor (PDGF)-AB decreases myocardial injury after coronary occlusion. However, PDGF-AB…”
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Neonatal plasminogen displays altered cell surface binding and activation kinetics : correlation with increased glycosylation of the protein by EDELBERG, J. M, ENGHILD, J. J, PIZZO, S. V, GONZALEZ-GRONOW, M

“…Plasminogen isolated from 60 full-term newborns differs from adult plasminogen in carbohydrate composition, kinetic activation constants, and cell binding…”
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PDGF mediates cardiac microvascular communication by Edelberg, J M, Aird, W C, Wu, W, Rayburn, H, Mamuya, W S, Mercola, M, Rosenberg, R D

“…The diversity of cellular and tissue functions within organs requires that local communication circuits control distinct populations of cells. Recently, we…”
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Platelet-derived growth factor-AB limits the extent of myocardial infarction in a rat model: Feasibility of restoring impaired angiogenic capacity in the aging heart by EDELBERG, Jay M, LEE, Seung H, KAUR, Manmeen, LILONG TANG, FEIRT, Nikki M, MCCABE, Samuel, BRAMWELL, Orville, CHIU WONG, S, HONG, Mun K

“…Compared with younger patients, myocardial infarction in the elderly has been associated with less favorable clinical outcomes, which may be attributable to a…”
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Aging-associated changes in vascular activity: a potential link to geriatric cardiovascular disease by Weinsaft, J W, Edelberg, J M

“…Ischemic cardiovascular disease is a common cause of morbidity and mortality in the United States population over the age of 65. Prior clinical studies have…”
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PDGF mediates cardiac microvascular communication by Edelberg, J M, Aird, W C, Wu, W, Rayburn, H, Mamuya, W S, Mercola, M, Rosenberg, R D

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Purification of Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase by Liu, J, Shworak, N W, Fritze, L M, Edelberg, J M, Rosenberg, R D

“…The cellular generation of proteoglycans with anticoagulant heparan sulfate (HSPG act ) is determined by microsomal “HS act conversion activity” that…”
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Regulation of Vascular Bed–Specific Prothrombotic Potential by Edelberg, Jay M, Christie, Patricia D, Rosenberg, Robert D

“…ABSTRACT—Hemostasis is the result of interdependent and complex systemic and local endothelial pathways that govern vascular integrity and rheology. A striking…”
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