Search Results - "Eddy, Sean F."

The Role of Hypoxia in 2-Butoxyethanol–Induced Hemangiosarcoma by Laifenfeld, Daphna, Gilchrist, Annalyn, Drubin, David, Jorge, Milena, Eddy, Sean F., Frushour, Brian P., Ladd, Bill, Obert, Leslie A., Gosink, Mark M., Cook, Jon C., Criswell, Kay, Somps, Christopher J., Koza-Taylor, Petra, Elliston, Keith O., Lawton, Michael P.

“…To understand the molecular mechanisms underlying compound-induced hemangiosarcomas in mice, and therefore, their human relevance, a systems biology approach…”
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Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate by EDDY, Sean F, KANE, Susan E, SONENSHEIN, Gail E

“…Overexpression of the epidermal growth factor receptor family member HER2 is found in approximately 30% of breast cancers and is a target for immunotherapy…”
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RelB NF-κB Represses Estrogen Receptor α Expression via Induction of the Zinc Finger Protein Blimp1 by Wang, Xiaobo, Belguise, Karine, O'Neill, Christine F., Sánchez-Morgan, Nuria, Romagnoli, Mathilde, Eddy, Sean F., Mineva, Nora D., Yu, Ziyang, Min, Chengyin, Trinkaus-Randall, Vickery, Chalbos, Dany, Sonenshein, Gail E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Inducible IκB kinase/IκB kinase ε expression is induced by CK2 and promotes aberrant nuclear factor-κB activation in breast cancer cells by EDDY, Sean F, SHANGQIN GUO, DEMICCO, Elizabeth G, ROMIEU-MOUREZ, Raphaëlle, LANDESMAN-BOLLAG, Esther, SELDIN, David C, SONENSHEIN, Gail E

“…Abstract Aberrant activation of nuclear factor-κB (NF-κB) transcription factors has been implicated in the pathogenesis of breast cancer. We previously showed…”
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Construction of a computable cell proliferation network focused on non-diseased lung cells by Westra, Jurjen W, Schlage, Walter K, Frushour, Brian P, Gebel, Stephan, Catlett, Natalie L, Han, Wanjiang, Eddy, Sean F, Hengstermann, Arnd, Matthews, Andrea L, Mathis, Carole, Lichtner, Rosemarie B, Poussin, Carine, Talikka, Marja, Veljkovic, Emilija, Van Hooser, Aaron A, Wong, Benjamin, Maria, Michael J, Peitsch, Manuel C, Deehan, Renee, Hoeng, Julia

“…Critical to advancing the systems-level evaluation of complex biological processes is the development of comprehensive networks and computational methods to…”
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Comparative molecular physiological genomics. Heterologous probing of cDNA arrays by Eddy, Sean F, Storey, Kenneth B

“…The use of DNA microarrays has gained wider acceptance as a standard tool for molecular biology studies over the past decade. In particular, biomedical studies…”
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Up-regulation of a thioredoxin peroxidase-like protein, proliferation-associated gene, in hibernating bats by Eddy, Sean F., McNally, J.D., Storey, K.B.

“…Two-dimensional gel electrophoresis was used to assess differential protein expression between euthermic and hibernating states in heart of Myotis lucifugus. A…”
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Cloning and expression of PPARγ and PGC-1α from the hibernating ground squirrel, Spermophilus tridecemlineatus by Eddy, Sean F., Morin, Pier, Storey, Kenneth B.

“…The peroxisome proliferator-activated receptor (PPAR) family of transcription factors play a key role in lipid metabolism and have been implicated in a number…”
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Differential expression of selected mitochondrial genes in hibernating little brown bats, Myotis lucifugus by Eddy, Sean F., Morin Jr, Pier, Storey, Kenneth B.

“…High rates of non‐shivering thermogenesis by brown adipose tissue accompanied by additional shivering thermogenesis in skeletal muscle provide the powerful…”
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p38 MAPK regulation of transcription factor targets in muscle and heart of the hibernating bat, Myotis lucifugus by Eddy, Sean F, Storey, Kenneth B

“…Mammalian hibernation combines a profound net metabolic rate suppression with the selective up-regulation of key genes whose protein products address specific…”
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NF-κB and epithelial to mesenchymal transition of cancer by Min, Chengyin, Eddy, Sean F., Sherr, David H., Sonenshein, Gail E.

“…During progression of an in situ to an invasive cancer, epithelial cells lose expression of proteins that promote cell–cell contact, and acquire mesenchymal…”
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Up-regulation of fatty acid-binding proteins during hibernation in the little brown bat, Myotis lucifugus by Eddy, Sean F., Storey, Kenneth B.

“…Hibernating animals rely primarily on lipids throughout winter as their primary fuel source, thus it is hypothesized that an increase in genes and proteins…”
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MO059: Trajectory Analysis of the Kidney Organoid Proteome Extends its Modelling Potential of Disease by Lassé, Moritz, Bonin, Léna L, El Saghir, Jamal, Eddy, Sean F, Hutzfeldt, Arvid, Hoxha, Elion, Dumoulin, Bernhard, Lindenmeyer, Maja, Schlüter, Hartmut, Beck, Bodo B, Brandts, Paul, Kretzler, Matthias, Demir, Fatih, Harder, Jennifer L, Rinschen, Markus

“…Abstract BACKGROUND AND AIMS Kidney organoids are a valuable and innovative model to understand genetic diseases, kidney development and transcriptomic…”
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Abstract B27: OncoPredictor: High copy number gain of ERBB2 predicts sensitivity to lapatinib by Eddy, Sean F., Tomilo, Mark, Sadis, Seth, Williams, Paul, Wyngaard, Peter, Rhodes, Daniel

“…Abstract Investigational new drugs for cancer must demonstrate convincing preclinical efficacy and a compelling strategy to translate preclinical observations…”
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Abstract 2897: Discovery and characterization of driver MAPK and PI3K pathway mutations in tumors and association with drug response in cell lines by Tomilo, Mark, Williams, Paul D., Bowden, Emma T., Gajjala, Supra R., Bandla, Santhoshi, Eddy, Sean F., Sadis, Seth E., Wyngaard, Peter J., Khazanov, Nickolay A., Rhodes, Daniel R.

“…Abstract The MAPK and PI3K pathways are frequently altered in human cancer and are targeted by dozens of agents in clinical trials. The successful application…”
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Abstract 3173: High-throughput, systematic analysis of paired-end next-generation sequencing data to characterize the gene fusion landscape in cancer by Sadis, Seth E., Khazanov, Nickolay A., Bankhead, Armand R., Cyanam, Dinesh, Williams, Paul D., Eddy, Sean F., Wyngaard, Peter J., Rhodes, Daniel R.

“…Abstract Gene fusions encode oncogenic drivers in hematological and solid tumors and are often associated with dramatic clinical responses with the appropriate…”
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Abstract 3665: An EMT gene expression diagnostic predicts resistance to EGFR and MEK-targeted therapies in cell lines and patients by Eddy, Sean F., Williams, Paul, Tomilo, Mark, Sadis, Seth, Wyngaard, Peter, Vo, Lien, Oades, Kahuku, Kim, Hyunsoo, Wang, Yipeng, Lee, Byung-In, Monforte, Joseph, Rhodes, Daniel

“…Abstract The epithelial to mesenchymal transition (EMT) in cancer cells results in the acquisition of metastatic properties and may contribute to…”
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Abstract 3149: OncoPredictor: A systematic approach for predicting responsive cancer populations from large scale cell line screening by Tomilo, Mark, Eddy, Sean F., Banka, Wendy Lockwood, Sadis, Seth E., Williams, Paul D., Wyngaard, Peter J., O'Day, Christine, Ovechkino, Yulia, Warrior, Usha, Rhodes, Daniel R.

“…Abstract Investigational new drugs for cancer must demonstrate convincing preclinical efficacy and a compelling strategy to translate preclinical observations…”
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p38MAPK regulation of transcription factor targets in muscle and heart of the hibernating bat, Myotis lucifugus by Eddy, Sean F., Storey, Kenneth B.

“…Mammalian hibernation combines a profound net metabolic rate suppression with the selective up‐regulation of key genes whose protein products address specific…”
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RelB NF-B Represses Estrogen Receptor Expression via Induction of the Zinc Finger Protein Blimp1 by Wang, Xiaobo, Belguise, Karine, O'Neill, Christine F, Sanchez-Morgan, Nuria, Romagnoli, Mathilde, Eddy, Sean F, Mineva, Nora D, Yu, Ziyang, Min, Chengyin, Trinkaus-Randall, Vickery, Chalbos, Dany, Sonenshein, Gail E

“…Aberrant constitutive expression of NF-B subunits, reported in more than 90% of breast cancers and multiple other malignancies, plays pivotal roles in…”
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