Search Results - "Eddy, A. Craig"

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions by Rettie, Allan E, Korzekwa, Kenneth R, Kunze, Kent L, Lawrence, Ross F, Eddy, A Craig, Aoyama, Toshifumi, Gelboin, Harry V, Gonzalez, Frank J, Trager, William F

“…Previous kinetic studies have identified a high-affinity (S)-warfarin 7-hydroxylase present in human liver microsomes which appears to be responsible for the…”
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The mechanism of the interaction between amiodarone and warfarin in humans by Heimark, L D, Wienkers, L, Kunze, K, Gibaldi, M, Eddy, A C, Trager, W F, O'Reilly, R A, Goulart, D A

“…Amiodarone decreased the total body clearance of both (R)- and (S)-warfarin in normal subjects but did not change volumes of distribution. Warfarin excretion…”
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Mechanisms of the stereoselective interaction between miconazole and racemic warfarin in human subjects by O'Reilly, R A, Goulart, D A, Kunze, K L, Neal, J, Gibaldi, M, Eddy, A C, Trager, W F

“…Miconazole decreased the total body clearance of both (R)- and (S)-warfarin in normal subjects but did not change volumes of distribution. Miconazole inhibited…”
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Bioactivation of aflatoxin B1 by human liver microsomes: role of cytochrome P450 IIIA enzymes by Ramsdell, H S, Parkinson, A, Eddy, A C, Eaton, D L

“…Based on our previous observations (H. S. Ramsdell and D. L. Eaton, 1990, Cancer Res. 50, 615-620) that the proportion of aflatoxin B1 (AFB1) converted to the…”
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Inhibition of human liver microsomal epoxide hydrolase by valproate and valpromide: in vitro/in vivo correlation by Kerr, B M, Rettie, A E, Eddy, A C, Loiseau, P, Guyot, M, Wilensky, A J, Levy, R H

“…On the basis of drug interactions with carbamazepine epoxide, it has been hypothesized that valproic acid and valpromide are inhibitors of epoxide hydrolase,…”
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Carbamazepine dose requirements during stiripentol therapy: influence of cytochrome P-450 inhibition by stiripentol by Kerr, B M, Martinez-Lage, J M, Viteri, C, Tor, J, Eddy, A C, Levy, R H

“…The inhibitory effect of stiripentol (STP) on disposition of carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZE) was quantitated to establish CBZ dosage…”
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Metabolic enantiomeric interactions: the inhibition of human (S)-warfarin-7-hydroxylase by (R)-warfarin by Kunze, K L, Eddy, A C, Gibaldi, M, Trager, W F

“…Inhibition of the metabolism of (S)-warfarin, the more pharmacologically active enantiomer of the racemic drug, by (R)-warfarin was investigated in microsomes…”
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Lack of effect of cimetidine on acetaminophen disposition in humans by Slattery, J T, McRorie, T I, Reynolds, R, Kalhorn, T F, Kharasch, E D, Eddy, A C

“…The effect of cimetidine administration on the disposition of acetaminophen was evaluated in seven men and six women. One gram of acetaminophen was…”
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Traumatic pneumoperitoneum following combined abdominal and thoracic injury by Luna, G K, Eddy, A C

“…Pneumoperitoneum following blunt abdominal trauma in the absence of other signs of severe intraabdominal injury is a rare finding. Although the vast majority…”
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Traumatic rupture of the thoracic aorta in the pediatric patient by Eddy, A C, Misbach, G A, Luna, G K

“…Traumatic rupture of the thoracic aorta is rare in pediatric patients. Proper management of this injury is essential and requires a systematic approach,…”
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General Surgery by Eddy, A. Craig, Rice, Charles L.

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Modified conduit preparation creates a pseudosinus in an aortic valve–sparing procedure for aneurysm of the ascending aorta by Cochran, Richard P., Kunzelman, Karyn S., Eddy, A.Craig, Hofer, Bradley O., Verrier, Edward D.

“…Mechanical valved conduit replacement of the aortic root is a durable and appropriate procedure for many diseases of the ascending aorta, but may sacrifice an…”
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The epidemiology of traumatic rupture of the thoracic aorta in children: a 13-year review by Eddy, A C, Rusch, V W, Fligner, C L, Reay, D T, Rice, C L

“…Traumatic rupture of the thoracic aorta (TRA) is a rare but highly lethal injury in children that occurs as a result of car versus pedestrian accidents and…”
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Empyema thoracis in patients undergoing emergent closed tube thoracostomy for thoracic trauma by Eddy, A C, Luna, G K, Copass, M

“…The vast majority of thoracic trauma victims require only observation or tube thoracostomy for definitive treatment of their thoracic injury. Although tube…”
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Influence of dexmedetomidine and clonidine on human liver microsomal alfentanil metabolism by Kharasch, E D, Hill, H F, Eddy, A C

“…Perioperative administration of the alpha 2 agonist clonidine has been shown to increase plasma alfentanil concentrations; however, the mechanism for this…”
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The sensitivity of vital signs in identifying major thoracoabdominal hemorrhage by Luna, G K, Eddy, A C, Copass, M

“…Prehospital and emergency room recordings of hemodynamic vital signs frequently play a major role in the evaluation and treatment of trauma victims. Guidelines…”
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Tricuspid valve repair for tricuspid valve endocarditis: Tricuspid valve “recycling” by Allen, Margaret D., Slachman, Frank, Eddy, A.Craig, Cohen, Daniel, Otto, Catherine M., Pearlman, Alan S.

“…Tricuspid valve endocarditis traditionally has been treated with either valve excision or valve replacement. To avoid implantation of foreign material in an…”
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Right ventricular dysfunction in multiple trauma victims by Eddy, A C, Rice, C L, Anardi, D M

“…We studied 17 victims of multiple trauma and found that right ventricular function can be reliably monitored at the bedside using the thermodilution method. In…”
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Upper abdominal wall defects: immediate or staged reconstruction? by Gottlieb, J R, Engrav, L H, Walkinshaw, M D, Eddy, A C, Herman, C M

“…One-stage reconstruction of the central and lower abdominal wall with vascularized tissue has been well described. A few cases of one-stage reconstruction of…”
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Chemical synthesis, absolute configuration, and stereochemistry of formation of 10-hydroxywarfarin: a major oxidative metabolite of (+)-(R)-warfarin from hepatic microsomal preparations by Lawrence, R F, Rettie, A E, Eddy, A C, Trager, W F

“…The synthesis of a diastereomerically pure 10-hydroxywarfarin [4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-1 benzopyran-2-one] was accomplished in three…”
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