Search Results - "Eddie, Sharon L."

TBX2 acts as a potent transcriptional silencer of tumour suppressor genes through interaction with the CoREST complex to sustain the proliferation of breast cancers by McIntyre, Alexander J, Angel, Charlotte Z, Smith, James S, Templeman, Amy, Beattie, Katherine, Beattie, Shannon, Ormrod, Alice, Devlin, Eadaoin, McGreevy, Charles, Bothwell, Chloe, Eddie, Sharon L, Buckley, Niamh E, Williams, Rich, Mullan, Paul B

“…Chromosome 17q23 amplification occurs in 20% of primary breast tumours and is associated with poor outcome. The TBX2 gene is located on 17q23 and is often…”
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Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents by van den Driesche, Sander, Walker, Marion, McKinnell, Chris, Scott, Hayley M, Eddie, Sharon L, Mitchell, Rod T, Seckl, Jonathan R, Drake, Amanda J, Smith, Lee B, Anderson, Richard A, Sharpe, Richard M

“…Reproductive disorders that are common/increasing in prevalence in human males may arise because of deficient androgen production/action during a fetal…”
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Defining the molecular evolution of extrauterine high grade serous carcinoma by Beirne, James P, McArt, Darragh G, Roddy, Aideen, McDermott, Clara, Ferris, Jennifer, Buckley, Niamh E, Coulter, Paula, McCabe, Nuala, Eddie, Sharon L, Dunne, Philip D, O'Reilly, Paul, Gilmore, Alan, Feeney, Laura, Ewing, David Lyons, Drapkin, Ronny I, Salto-Tellez, Manuel, Kennedy, Richard D, Harley, Ian J.G, McCluggage, W. Glenn, Mullan, Paul B

“…AbstractObjectiveHigh grade serous carcinoma (HGSC) is the most common and most aggressive, subtype of epithelial ovarian cancer. It presents as advanced stage…”
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Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences by Dean, Afshan, van den Driesche, Sander, Wang, Yili, McKinnell, Chris, Macpherson, Sheila, Eddie, Sharon L., Kinnell, Hazel, Hurtado-Gonzalez, Pablo, Chambers, Tom J., Stevenson, Kerrie, Wolfinger, Elke, Hrabalkova, Lenka, Calarrao, Ana, Bayne, Rosey AL, Hagen, Casper P., Mitchell, Rod T., Anderson, Richard A., Sharpe, Richard M.

“…Analgesics which affect prostaglandin (PG) pathways are used by most pregnant women. As germ cells (GC) undergo developmental and epigenetic changes in fetal…”
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Mutant p53 expression in fallopian tube epithelium drives cell migration by Quartuccio, Suzanne M., Karthikeyan, Subbulakshmi, Eddie, Sharon L., Lantvit, Daniel D., Ó hAinmhire, Eoghainín, Modi, Dimple A., Wei, Jian‐Jun, Burdette, Joanna E.

“…Ovarian cancer is the fifth leading cause of cancer death among US women. Evidence supports the hypothesis that high‐grade serous ovarian cancers (HGSC) may…”
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Identification and SAR exploration of a novel series of Legumain inhibitors by Eddie, Sharon L., Gregson, Aaron, Graham, Emma, Burton, Stephanie, Harrison, Timothy, Burden, Roberta, Scott, Christopher J., Mullan, Paul B., Williams, Rich

“…[Display omitted] This letter describes the development of a series of potent and selective small molecule Legumain inhibitors suitable as chemical probes for…”
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Microphysiological modeling of the reproductive tract: a fertile endeavor by Eddie, Sharon L, Kim, J Julie, Woodruff, Teresa K, Burdette, Joanna E

“…Preclinical toxicity testing in animal models is a cornerstone of the drug development process, yet it is often unable to predict adverse effects and…”
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Three-dimensional modeling of the human fallopian tube fimbriae by Eddie, Sharon L, Quartuccio, Suzanne M, Zhu, Jie, Shepherd, Jessica A, Kothari, Rajul, Kim, J. Julie, Woodruff, Teresa K, Burdette, Joanna E

“…Abstract Objective Ovarian cancer is the most lethal gynecological malignancy that affects women. Recent data suggests that the disease may originate in the…”
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Flat SAR of P3-methylsulphonamide based small molecule legumain inhibitors by Ness, Kerry Anne, Eddie, Sharon L., Burton, Stephanie, Harrison, Timothy, Mullan, Paul, Williams, Rich

“…[Display omitted] This letter describes the design, development and SAR exploration of a novel series of small legumain inhibitors. The SAR of a new small…”
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Prokineticin Ligands and Receptors Are Expressed in the Human Fetal Ovary and Regulate Germ Cell Expression of COX2 by Eddie, Sharon L, Childs, Andrew J, Kinnell, Hazel L, Brown, Pamela, Jabbour, Henry N, Anderson, Richard A

“…Context: Fetal ovarian development and primordial follicle formation underpin future female fertility. Prokineticin (PROK) ligands regulate cell survival,…”
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Investigating Radiotherapy Response in a Novel Syngeneic Model of Prostate Cancer by Haughey, Charles M, Mukherjee, Debayan, Steele, Rebecca E, Popple, Amy, Dura-Perez, Lara, Pickard, Adam, Patel, Mehjabin, Jain, Suneil, Mullan, Paul B, Williams, Rich, Oliveira, Pedro, Buckley, Niamh E, Honeychurch, Jamie, S McDade, Simon, Illidge, Timothy, Mills, Ian G, Eddie, Sharon L

“…The prostate cancer (PCa) field lacks clinically relevant, syngeneic mouse models which retain the tumour microenvironment observed in PCa patients. This study…”
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Tumorigenesis and peritoneal colonization from fallopian tube epithelium by Eddie, Sharon L, Quartuccio, Suzanne M, Ó hAinmhir, Eoghainin, Moyle-Heyrman, Georgette, Lantvit, Dan D, Wei, Jian-Jun, Vanderhyden, Barbara C, Burdette, Joanna E

“…Ovarian cancer is the most lethal gynecological malignancy, primarily because its origin and initiation factors are unknown. A secretory murine oviductal…”
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Development of a potent and selective cell penetrant Legumain inhibitor by Ness, Kerry A., Eddie, Sharon L., Higgins, Catherine A., Templeman, Amy, D’Costa, Zenobia, Gaddale, Kishore K.D., Bouzzaoui, Samira, Jordan, Linda, Janssen, Dominic, Harrison, Timothy, Burkamp, Frank, Young, Andrew, Burden, Roberta, Scott, Christopher J., Mullan, Paul B., Williams, Rich

“…[Display omitted] This Letter describes the continued SAR exploration of small molecule Legumain inhibitors with the aim of developing a potent and selective…”
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Developmentally regulated IL6-type cytokines signal to germ cells in the human fetal ovary by Eddie, Sharon L., Childs, Andrew J., Jabbour, Henry N., Anderson, Richard A.

“…Fetal ovarian development and primordial follicle formation are imperative for adult fertility in the female. Data suggest the interleukin (IL)6-type…”
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Prostaglandin E2 as a Regulator of Germ Cells during Ovarian Development by Bayne, Rosemary A. L., Eddie, Sharon L., Collins, Craig S., Childs, Andrew J., Jabbour, Henry N., Anderson, Richard A.

“…Context: The formation of primordial follicles occurs during fetal life yet is critical to the determination of adult female fertility. Prior to this stage,…”
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Insulin and insulin-like growth factor signaling increases proliferation and hyperplasia of the ovarian surface epithelium and decreases follicular integrity through upregulation of the PI3-kinase pathway by King, Shelby M, Modi, Dimple A, Eddie, Sharon L, Burdette, Joanna E

“…The ovarian surface epithelium responds to cytokines and hormonal cues to initiate proliferation and migration following ovulation. Although insulin and IGF…”
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Prostaglandin E2 as a Regulator of Germ Cells during Ovarian Development by Bayne, Rosemary A. L, Eddie, Sharon L, Collins, Craig S, Childs, Andrew J, Jabbour, Henry N, Anderson, Richard A

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Abstract 3988: Legumain regulates advanced prostate cancer via HSD17B4 by Eddie, Sharon L., Ormrod, Alice V., Williams, Rich, Mullan, Paul B.

“…Abstract Prostate cancer is the most common male cancer diagnosis. However, current treatment is limited and patients often develop resistant, metastatic…”
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Abstract B7: Molecular signaling in the human fallopian tube: Insights into proliferation and p53 expression by Eddie, Sharon L., Quartuccio, Suzanne M., Shepherd, Jessica A., Kothari, Rajul, Burdette, Joanna E.

“…Abstract Ovarian cancer is the most lethal gynecological malignancy in women. This is primarily due to patients presenting in late stage disease when the…”
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Prokineticins Exert Anti-Apoptotic Effects in the Human Fetal Testis by Eddie, Sharon L., Kilcoyne, Karen, Childs, Andrew, Jabbour, Henry, Anderson, Richard

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