Search Results - "Edd, Jon"

Oscillatory inertial focusing in infinite microchannels by Mutlu, Baris R., Edd, Jon F., Toner, Mehmet

“…Inertial microfluidics (i.e., migration and focusing of particles in finite Reynolds number microchannel flows) is a passive, precise, and high-throughput…”
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Particle segregation and dynamics in confined flows by Di Carlo, Dino, Edd, Jon F, Humphry, Katherine J, Stone, Howard A, Toner, Mehmet

“…Nonlinearity in finite-Reynolds-number flow results in particle migration transverse to fluid streamlines, producing the well-known "tubular pinch effect" in…”
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Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells by Mishra, Avanish, Dubash, Taronish D., Edd, Jon F., Jewett, Michelle K., Garre, Suhaas G., Karabacak, Nezihi Murat, Rabe, Daniel C., Mutlu, Baris R., Walsh, John R., Kapur, Ravi, Stott, Shannon L., Maheswaran, Shyamala, Haber, Daniel A., Toner, Mehmet

“…Circulating tumor cell (CTC)-based liquid biopsies provide unique opportunities for cancer diagnostics, treatment selection, and response monitoring, but even…”
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A microfluidic transistor for automatic control of liquids by Gopinathan, Kaustav A., Mishra, Avanish, Mutlu, Baris R., Edd, Jon F., Toner, Mehmet

“…Microfluidics have enabled notable advances in molecular biology 1 , 2 , synthetic chemistry 3 , 4 , diagnostics 5 , 6 and tissue engineering 7 . However,…”
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Inertio-elastic focusing of bioparticles in microchannels at high throughput by Lim, Eugene J., Ober, Thomas J., Edd, Jon F., Desai, Salil P., Neal, Douglas, Bong, Ki Wan, Doyle, Patrick S., McKinley, Gareth H., Toner, Mehmet

“…Controlled manipulation of particles from very large volumes of fluid at high throughput is critical for many biomedical, environmental and industrial…”
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Microfluidic capture of chromatin fibres measures neutrophil extracellular traps (NETs) released in a drop of human blood by Sakuma, Miyuki, Wang, Xiao, Ellett, Felix, Edd, Jon F, Babatunde, Kehinde Adebayo, Viens, Adam, Mansour, Michael K, Irimia, Daniel

“…Neutrophils are the largest population of white blood cells in the circulation, and their primary function is to protect the body from microbes. They can…”
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Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells by Fachin, Fabio, Spuhler, Philipp, Martel-Foley, Joseph M., Edd, Jon F., Barber, Thomas A., Walsh, John, Karabacak, Murat, Pai, Vincent, Yu, Melissa, Smith, Kyle, Hwang, Henry, Yang, Jennifer, Shah, Sahil, Yarmush, Ruby, Sequist, Lecia V., Stott, Shannon L., Maheswaran, Shyamala, Haber, Daniel A., Kapur, Ravi, Toner, Mehmet

“…Circulating tumor cells (CTCs) are a treasure trove of information regarding the location, type and stage of cancer and are being pursued as both a diagnostic…”
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Equilibrium Separation and Filtration of Particles Using Differential Inertial Focusing by Di Carlo, Dino, Edd, Jon F, Irimia, Daniel, Tompkins, Ronald G, Toner, Mehmet

“…Rapid separation and filtration of particles in solution has a wide range of applications including blood cell separation, ultrasound contrast agent…”
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Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry by Au, Sam H., Edd, Jon, Stoddard, Amy E., Wong, Keith H. K., Fachin, Fabio, Maheswaran, Shyamala, Haber, Daniel A., Stott, Shannon L., Kapur, Ravi, Toner, Mehmet

“…Circulating tumor cell clusters (CTC clusters) are potent initiators of metastasis and potentially useful clinical markers for patients with cancer. Although…”
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Microfluidic concentration and separation of circulating tumor cell clusters from large blood volumes by Edd, Jon F, Mishra, Avanish, Dubash, Taronish D, Herrera, Stefan, Mohammad, Ridhwan, Williams, E Kendall, Hong, Xin, Mutlu, Baris R, Walsh, John R, Machado de Carvalho, Fernanda, Aldikacti, Berent, Nieman, Linda T, Stott, Shannon L, Kapur, Ravi, Maheswaran, Shyamala, Haber, Daniel A, Toner, Mehmet

“…Circulating tumor cells (CTCs) are extremely rare in the blood, yet they account for metastasis. Notably, it was reported that CTC clusters (CTCCs) can be…”
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Dynamic particle ordering in oscillatory inertial microfluidics by Dietsche, Claudius, Mutlu, Baris R., Edd, Jon F., Koumoutsakos, Petros, Toner, Mehmet

“…Particles suspended in conduit flows at small and intermediate Reynolds numbers cluster on specific focal positions while also forming particle pairs and…”
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Label‐Free Microfluidic Apheresis of Circulating Tumor Cell Clusters by Zhan, Li, Edd, Jon, Mishra, Avanish, Toner, Mehmet

“…Screening liters of blood (i.e., apheresis) represents a generalized approach to promote the reliable access to circulating tumor cell clusters (CTCCs), which…”
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Differential inertial focusing of particles in curved low-aspect-ratio microchannels by Russom, Aman, Gupta, Amit K, Nagrath, Sunitha, Carlo, Dino Di, Edd, Jon F, Toner, Mehmet

“…Microfluidic-based manipulation of particles is of great interest due to the insight it provides into the physics of hydrodynamic forces. Here, we study a…”
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Non-equilibrium Inertial Separation Array for High-throughput, Large-volume Blood Fractionation by Mutlu, Baris R., Smith, Kyle C., Edd, Jon F., Nadar, Priyanka, Dlamini, Mcolisi, Kapur, Ravi, Toner, Mehmet

“…Microfluidic blood processing is used in a range of applications from cancer therapeutics to infectious disease diagnostics. As these applications are being…”
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In-flow measurement of cell-cell adhesion using oscillatory inertial microfluidics by Mutlu, Baris R, Dubash, Taronish, Dietsche, Claudius, Mishra, Avanish, Ozbey, Arzu, Keim, Kevin, Edd, Jon F, Haber, Daniel A, Maheswaran, Shyamala, Toner, Mehmet

“…Multicellular clusters in circulation can exhibit a substantially different function and biomarker significance compared to individual cells. Notably, clusters…”
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Retina-on-a-chip: a microfluidic platform for point access signaling studies by Dodson, Kirsten H., Echevarria, Franklin D., Li, Deyu, Sappington, Rebecca M., Edd, Jon F.

“…We report on a microfluidic platform for culture of whole organs or tissue slices with the capability of point access reagent delivery to probe the transport…”
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Bacterial Ice Nucleation in Monodisperse D2O and H2O‑in-Oil Emulsions by Weng, Lindong, Tessier, Shannon N, Smith, Kyle, Edd, Jon F, Stott, Shannon L, Toner, Mehmet

“…Ice nucleation is of fundamental significance in many areas, including atmospheric science, food technology, and cryobiology. In this study, we investigated…”
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Controlled encapsulation of single-cells into monodisperse picolitre drops by Edd, Jon F, Di Carlo, Dino, Humphry, Katherine J, Köster, Sarah, Irimia, Daniel, Weitz, David A, Toner, Mehmet

“…Encapsulation of cells within picolitre-size monodisperse drops provides new means to perform quantitative biological studies on a single-cell basis for large…”
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Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody by Micalizzi, Douglas S, Che, Dante, Nicholson, Benjamin T, Edd, Jon F, Desai, Niyati, Lang, Evan R, Toner, Mehmet, Maheswaran, Shyamala, Ting, David T, Haber, Daniel A

“…The successful application of antibody-based therapeutics in either primary or metastatic cancer depends upon the selection of rare cell surface epitopes that…”
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Isolation of circulating tumor cells by Edd, Jon F., Mishra, Avanish, Smith, Kyle C., Kapur, Ravi, Maheswaran, Shyamala, Haber, Daniel A., Toner, Mehmet

“…Circulating tumor cells (CTCs) enter the vasculature from solid tumors and disseminate widely to initiate metastases. Mining the metastatic-enriched molecular…”
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