Search Results - "Edbrooke, Mark R"

Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs by Kamola, Piotr J., Maratou, Klio, Wilson, Paul A., Rush, Kay, Mullaney, Tanya, McKevitt, Tom, Evans, Paula, Ridings, Jim, Chowdhury, Probash, Roulois, Aude, Fairchild, Ann, McCawley, Sean, Cartwright, Karen, Gooderham, Nigel J., Gant, Timothy W., Moores, Kitty, Hughes, Stephen A., Edbrooke, Mark R., Clark, Kenneth, Parry, Joel D.

“…Antisense oligonucleotide (ASO) gapmers downregulate gene expression by inducing enzyme-dependent degradation of targeted RNA and represent a promising…”
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Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis by Clark, Kenneth L, Hughes, Stephen A, Bulsara, Pallav, Coates, Jill, Moores, Kitty, Parry, Joel, Carr, Michael, Mayer, Ruth J, Wilson, Paul, Gruenloh, Chris, Levin, Daren, Darton, Jill, Weber, Wolf-Michael, Sobczak, Katja, Gill, Deborah R, Hyde, Stephen C, Davies, Lee A, Pringle, Ian A, Sumner-Jones, Stephanie G, Jadhav, Vasant, Jamison, Sharon, Strapps, Walter R, Pickering, Victoria, Edbrooke, Mark R

“…Lung pathology in cystic fibrosis is linked to dehydration of the airways epithelial surface which in part results from inappropriately raised sodium…”
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In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization by Kamola, Piotr J, Kitson, Jeremy D A, Turner, Gemma, Maratou, Klio, Eriksson, Sofie, Panjwani, Aliza, Warnock, Linda C, Douillard Guilloux, Gaelle A, Moores, Kitty, Koppe, Emma L, Wixted, William E, Wilson, Paul A, Gooderham, Nigel J, Gant, Timothy W, Clark, Kenneth L, Hughes, Stephen A, Edbrooke, Mark R, Parry, Joel D

“…With many safety and technical limitations partly mitigated through chemical modifications, antisense oligonucleotides (ASOs) are gaining recognition as…”
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PMA Induces the MUC5AC Respiratory Mucin in Human Bronchial Epithelial Cells, via PKC, EGF/TGF-α, Ras/Raf, MEK, ERK and Sp1-dependent Mechanisms by Hewson, Christopher A., Edbrooke, Mark R., Johnston, Sebastian L.

“…Asthma and chronic obstructive pulmonary disease are highly prevalent and economically important inflammatory airway diseases associated with mucus…”
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Lewis X Biosynthesis in Helicobacter pylori by Martin, Stephen L., Edbrooke, Mark R., Hodgman, T. Charles, van den Eijnden, Dirk H., Bird, Michael I.

“…The lipopolysaccharide of certain strains ofHelicobacter pylori was recently shown to contain the Lewis X (Lex) trisaccharide (Galβ-1,4-(Fucα(1,3))-GlcNAc)…”
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Partial nucleotide sequence of human calcitonin precursor mRNA identifies flanking cryptic peptides by Craig, Roger K, Hall, Len, Edbrooke, Mark R, Allison, Janette, MacIntyre, Iain

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Lewis X biosynthesis in Helicobacter pylori. Molecular cloning of an alpha(1,3)-fucosyltransferase gene by Martin, S L, Edbrooke, M R, Hodgman, T C, van den Eijnden, D H, Bird, M I

“…The lipopolysaccharide of certain strains of Helicobacter pylori was recently shown to contain the Lewis X (Lex) trisaccharide (Galbeta-1,…”
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Pharmacological Characterization of a Novel ENaC[alpha] siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis by Clark, Kenneth L, Hughes, Stephen A, Bulsara, Pallav, Coates, Jill, Moores, Kitty, Parry, Joel, Carr, Michael, Mayer, Ruth J, Wilson, Paul, Gruenloh, Chris, Levin, Daren, Darton, Jill, Weber, Wolf-michael, Sobczak, Katja, Gill, Deborah R, Hyde, Stephen C, Davies, Lee A, Pringle, Ian A, Sumner-jones, Stephanie G, Jadhav, Vasant, Jamison, Sharon, Strapps, Walter R, Pickering, Victoria, Edbrooke, Mark R

“…Lung pathology in cystic fibrosis is linked to dehydration of the airways epithelial surface which in part results from inappropriately raised sodium…”
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Acceptor specificity of the human leukocyte α3 fucosyltransferase: role of FucT-VII in the generation of selectin ligands by Britten, Christopher J., van den Eijnden, Dirk H., McDowell, William, Kelly, Valerie A., Witham, Sara J., Edbrooke, Mark R., Bird, Michael I., de Vries, Theodora, Smithers, Nicholas

“…The α3 fucosyltransferase, FucT-VII, is one of the key glycosyltransferases involved in the biosynthesis of the sialyl Lewis X (sLex) antigen on human…”
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Expression of a secreted form of human alpha 1,3 fucosyltransferase VII from insect cells by Smithers, N, Kelly, V A, Witham, S J, Edbrooke, M R, Britten, C J

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Constitutive and NF-kappa B-like proteins in the regulation of the serum amyloid A gene by interleukin 1 by Edbrooke, M R, Foldi, J, Cheshire, J K, Li, F, Faulkes, D J, Woo, P

“…Serum amyloid A (SAA) is a major acute-phase protein whose chronic production by the liver can lead to the fatal disorder of secondary amyloidosis. Control of…”
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The human A3 adenosine receptor gene by Murrison, E, Goodson, S J, Harris, C A, Edbrooke, M R

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Ectopic synthesis of high‐M r calcitonin by the BEN lung carcinoma cell line reflects aberrant proteolytic processing by Riley, John H., Edbrooke, Mark R., Craig, Roger K.

“…Cloning and nucleotide sequence analysis of the human calcitonin mRNA from the BEN lung carcinoma cell line, a cell line known to secrete high‐M r forms of…”
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Comparison of the nucleotide sequence of cloned human and guinea-pig pre-α-lactalbumin cDNA with that of chick pre-lysozyme cDNA suggests evolution from a common ancestral gene by Hall, Len, Craig, Roger K., Edbrooke, Mark R., Campbell, Peter N.

“…Nucleotide sequence analyses of essentially full-length copies of human and guinea-pig pre-α-lactalbumin cDNAs contained within recombinant plasmids, (i)…”
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CHAPTER 29 - Role of Pharmacogenomics in Drug Development by Spraggs, Colin F., Koshy, Beena T., Edbrooke, Mark R., Roses, Allen D.

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Ectopic synthesis of high- Mr calcitonin by the BEN lung carcinoma cell line reflects aberrant proteolytic processing by Riley, John H., Edbrooke, Mark R., Craig, Roger K.

“…Cloning and nucleotide sequence analysis of the human calcitonin mRNA from the BEN lung carcinoma cell line, a cell line known to secrete high- M r forms of…”
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Identification of cis-Acting Sequences Responsible for Phorbol Ester Induction of Human Serum Amyloid A Gene Expression via a Nuclear Factor κB-Like Transcription Factor by Edbrooke, Mark R., Burt, David W., Cheshire, John K., Woo, Patricia

“…We have analyzed the 5′-flanking region of one of the genes coding for the human acute-phase protein, serum amyloid A (SAA). We found that SAA mRNA could be…”
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